Abstract: An optical sensor, optical system, and proximity sensor are disclosed. An illustrative proximity sensor is disclosed to include a light source, a photodetector including a photo-sensitive area that receives incident light and converts the received incident light into an electrical signal, and a plurality of polarization layers stacked on the photodetector that limit light from becoming received incident light for the photo-sensitive area to light traveling toward the photodetector along a predetermined path.

Abstract: An optical sensor, optical system, and proximity sensor are disclosed. An illustrative proximity sensor is disclosed to include a light source, a photodetector including a photo-sensitive area that receives incident light and converts the received incident light into an electrical signal, and a plurality of polarization layers stacked on the photodetector that limit light from becoming received incident light for the photo-sensitive area to light traveling toward the photodetector along a predetermined path.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: A proximity sensor device, which may detect the presence of external objects at close proximity is disclosed. The proximity sensor device may comprise an emitter, a detector, a separation wall and an internal channeling section. In one embodiment, the internal channeling section may be configured to direct light from the emitter to the detector when the external object is present at close proximity. In other embodiments, a proximity sensor assembly, an optical structure and an electronic device having similar internal channeling section are disclosed.

Abstract: A proximity sensor device, which may detect the presence of external objects at close proximity is disclosed. The proximity sensor device may comprise an emitter, a detector, a separation wall and an internal channeling section. In one embodiment, the internal channeling section may be configured to direct light from the emitter to the detector when the external object is present at close proximity. In other embodiments, a proximity sensor assembly, an optical structure and an electronic device having similar internal channeling section are disclosed.

Abstract: The present invention relates to a method for use in injection molding with the capability to have precise and adjustable control of the molten plastic flow when molding at least two (2) non-identical (i.e. with more than 50% difference in weight or form) or identical complex-shaped and intricate plastic parts at the same time, utilising a mold with at least two (2) parting layers via a standard conventional injection machine. This invention incorporates the principle of having two (2) valve pins in which their movements are back-to-back and can be independently opened and closed as controlled by stepper, servo or linear motors linked to a separate independent tool controller. The two (2) valve pins are positioned at the floating half of the mold for sequential, stack or multi-layer mold with multiple cavities.

Abstract: Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabeled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprises synthesizing an alkylating agent having the formula: X—(CR1R2)aCR3R4-LG wherein, a is 0, 1, 2 or 3, R1, R2, R3 and R4 are independently H, X or alkyl, X is a halogen or a label, with the proviso that at least one X is a halogen, LG is a leaving group; and directly reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound.

Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, ?3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: Compounds of Formula I: are HIV reverse transcriptase inhibitors, wherein V, W, X, Y, Z, R1, R2, R4, R5, R6, ring A, ring B, j and k are defined herein. The compounds of Formula I, and the pharmaceutically acceptable salts and prodrugs thereof, are useful in the inhibition of HIV reverse transcriptase, the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset or progression, and treatment of AIDS. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: Provided herein are methods for administering an efficacious amount of a compound of Formula I that reduce the severity of a potential adverse effect or obviate a potential adverse effect.

Abstract: A method for producing a single crystal ingot includes steps of providing a first amount of polycrystalline material and a first amount of dopant material to form a first mixture having a first dopant concentration in a process furnace, increasing a temperature of the first mixture to provide a molten first mixture, providing a seed material to the molten first mixture, withdrawing the seed from the molten first mixture by a first distance to form a boule having a first length, providing a second amount of the polycrystalline material and a second amount of the dopant material to the molten first mixture to provide a molten second mixture having the first dopant concentration, withdrawing the first length of the boule from the molten second mixture by a second distance to form the boule having a second length, and removing the boule from the molten second mixture to form the single crystal ingot of uniform axial resistivity.

Abstract: N-(Sulfonyloxybiarylmethyl)aminocyclopropanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway.

Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.

Abstract: In a transdermal drug delivery system, encapsulation material used to coat drug granules controls the release of an active ingredient. The active ingredient is released into a water retaining matrix, which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell, which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.

Abstract: In a transdermal drug delivery system, encapsulation material used to coat drug granules controls the release of an active ingredient. The active ingredient is released into a water retaining matrix, which acts as a reservoir, and transdermal drug penetration is driven by the resulting concentration gradient. The delivery system is enclosed in a patch comprising a composite shell, which acts as an occlusive covering when attached to skin, thus enhancing the hydration of the skin area and fostering absorption of the drug. Visible change indicators incorporated into the system provide indicators at significant "landmarks" in the lifetime of the patch. Microcapsules used for the indicator may be formulated so that the penetration of moisture effects a color change at a time when the active ingredient is almost exhausted. This feature alerts to the user to the need for application of a replacement patch.

Abstract: This invention relates to exchanging the sodium contained in a crystalline zeolite by partially removing sodium by exchange with another cation, partially drying the exchanged zeolite and re-exchanging the dried zeolite.