Abstract: A neurovascular occlusion device for occluding a vessel and a delivery system for delivering the occlusion device. The occlusion device can include a self-expandable support structure defining a concave occlusive component and an anchoring component separated by a neck component. The occlusive component can carry a functionally occlusive membrane configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is expanded in the vessel.

Abstract: As may be implemented in accordance with one or more embodiments, respective sets of media content data, having disparate formats, are received from disparate content providers. The content is reformatted into a common format type and restructured into renditions having an article-oriented structure. Reformatted assets are generated for each rendition based upon characteristics of devices by which the renditions are to be accessed. Device-indeterminate ID linking data is generated for linking portions of each rendition with the media content data received from the content providers.

Abstract: A clamp for clamping optical fiber to a tube. The clamp has a body portion coupled at one end to a first arm and at an opposing end to a second arm, and a resilient portion to permit the clamp to elastically deform from a closed state in which the clamp is fastened around the tube to an open state in which the clamp is radially moveable off the tube. At least one of the body portion, the first arm and the second arm has a clamping surface to clamp a portion of the optical fiber against the tube when the clamp is fastened around the tube, and a clamping mechanism operable to extend at least part of the clamping surface towards the tube when the clamp is secured to the tube to increase a clamping force applied by the clamping surface.

Abstract: Systems and methods for remote control and management of medical workstations using an instant messaging infrastructure. A remote client, such as a mobile phone, laptop, tablet, or other computing device, is used to generate instructions or information requests in one or more data packets. The remote client sends the one or more data packets using the instant messaging infrastructure to a medical workstation at another location. A service application in communication with the medical workstation receives the data packets and causes the medical workstation to retrieve the requested information or execute the instruction. The communications between the remote client and the service application are encrypted and signed to ensure secure communications.

Abstract: A system for treating a patient suffering from obstructive sleep apnea or snoring is diclsoed. The system includes an air flow generator configured to deliver an air flow at a positive therapeutic pressure during the treatment, and an expiratory valve with an open pressure connected air flow generator. The open pressure is dependent on the therapeutic pressure from the air flow generator. The expiratory valve further exerts a back pressure upon each exhalation from the patient sufficient to create a pneumatic splint in the patient's respiratory tract. The exhalation from the patient has a first half followed by a second half and the back pressure is varied such that during the start of the first half the back pressure is between 0 and 50% of a peak back pressure and increases to a peak back pressure in the second half.

Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.

Abstract: The present disclosure provides an immunogenic composition comprising: a) a hepatitis C virus (HCV) heterodimeric polypeptide that includes HCV E1 and E2 polypeptides; b) a T-cell epitope polypeptide comprising a T-cell epitope present in an HCV protein other than E1 and E2; and c) a pharmaceutically acceptable excipient. The present disclosure provides a method of inducing an immune response, in an individual, to an HCV polypeptide. The present disclosure provides an immunogenic composition comprising: a) a polypeptide that comprises one or more T-cell epitopes present in an HCV protein other than E1 and E2; and b) a pharmaceutically acceptable excipient.

Abstract: An interrogator and system employing the same. In one embodiment, the interrogator includes a receiver configured to receive a return signal from a tag and a sensing module configured to provide a time associated with the return signal. The interrogator also includes a processor configured to employ synthetic aperture radar processing on the return signal in accordance with the time to locate a position of the tag.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.

Abstract: The present disclosure provides heterodimeric polypeptides comprising: 1) a variant hepatitis C virus (HCV) E2 polypeptide and an HCV E1 polypeptide; 2) a variant HCV E1 polypeptide and an HCV E2 polypeptide; or 3) a variant HCV E1 polypeptide and a variant HCV E2 polypeptide, where the variant HCV E2 polypeptide and/or the HCV E1 polypeptide comprises one or more T cell epitopes, present in an HCV polypeptide other than an HCV E1 polypeptide or an HCV E2 polypeptide. The present disclosure provides nucleic acids encoding a polyprotein that includes E1 and variant E2, E2 and variant E1, or variant E2 and variant E1. The present disclosure provides a method of producing an E1/E2 heterodimer of the present disclosure. The present disclosure provides a method of inducing an immune response in an individual. The present disclosure provides variant E2 polypeptides and variant E1 polypeptides; and nucleic acids encoding same.

Abstract: Stent delivery systems and associated methods for delivering stents are disclosed herein. In several embodiments, a handle assembly for delivering a stent from a tubular enclosure can include a first lead screw having a first lead thread of a first pitch and first handedness, a second lead screw having a second lead thread of a second pitch and second handedness different from the first handedness, and a housing defining threads of the first and second pitches. The first lead screw can be in mechanical communication with the tubular enclosure, and the second lead screw can be in mechanical communication with the stent. Upon rotation of a portion of the housing, the housing threads can engage the lead screws so as to induce simultaneous translations of the lead screws in opposite directions. The simultaneous translations are configured to deploy the stent from the tubular enclosure.

Abstract: A vascular occlusion device having an expandable frame that carries a membrane. The membrane can include a tubular portion configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.

Abstract: A device for treating a patient suffering from obstructive sleep apnea or snoring can include an expiratory valve connected to a manifold. The expiratory valve can include a body portion including a feedback port configured to be connected to an air flow generator. The expiratory valve can include a plunger at least partially disposed in the body portion. The expiratory valve can include a pressurizing chamber positioned between an end of the plunger and an end of the expiratory valve. The pressurizing chamber can be configured to receive air from the air flow generator through the feedback port.

Abstract: In one embodiment, a stylus includes one or more electrodes and one or more computer-readable non-transitory storage media embodying first logic for transmitting signals wirelessly to a device through a touch-sensor of the device. The stylus has a first power mode in which components of the stylus for receiving signals from or transmitting signals to the device are powered off; a second power mode in which components of the stylus for receiving signals from the device are powered on at least periodically and components of the stylus for transmitting signals to the device are powered off; and a third power mode in which components of the stylus for transmitting signals to the device are powered on at least periodically. The media further embodies second logic for transitioning the stylus from one of the first, second, and third power modes to another one of the first, second, and third power modes.

Abstract: The present disclosure describes an occlusion device and methods of delivering the occlusion device. The occlusion device can include an expandable structure configured to move between an unexpanded configuration and an expanded configuration. The expandable structure can be configured to have an expansion ratio of at least about 5:1. Further, the occlusion device can be configured to prevent substantially all fluid from flowing past the occlusion device when the occlusion device is in the expanded configuration in the vessel.

Abstract: An embodiment of an apparatus for adjusting a distance between an electrode and a liquid includes a control circuit and a sense circuit. The control circuit is configured to couple an applied calibration signal to the electrode, and to cause a motor to position the electrode a distance from the liquid in response to a sense signal. And the sense circuit is configured to generate the sense signal in response to the applied calibration signal. For example, such an apparatus can be configured for use as part of a system for producing a stable solution of suspended silver. As silver-containing electrodes shorten over time, and as the level of solution changes over time, the apparatus can move the electrodes toward or away from the solution to maintain the respective distance between each electrode and the solution within a range that has been shown to produce a solution of suitable quality.

Abstract: In one embodiment, a stylus includes one or more electrodes and one or more computer-readable non-transitory storage media embodying first logic for transmitting signals wirelessly to a device through a touch-sensor of the device. The stylus has a first power mode in which components of the stylus for receiving signals from or transmitting signals to the device are powered off; a second power mode in which components of the stylus for receiving signals from the device are powered on at least periodically and components of the stylus for transmitting signals to the device are powered off; and a third power mode in which components of the stylus for transmitting signals to the device are powered on at least periodically. The media further embodies second logic for transitioning the stylus from one of the first, second, and third power modes to another one of the first, second, and third power modes.

Abstract: As may be implemented in accordance with one or more embodiments, specific electronic magazines are generated based on user interests as follows. Respective sets of media content data, associated with disparate electronic magazines provided by disparate publishers, are accessed and formatted into a common computer data format type. The formatted sets of media content data are broken into subsets and stored. Remote access to the respective subsets of media content data is provided to a user at a remote interface circuit based on authorization data specifying disparate electronic magazines that the user is authorized to access. This user access is tracked and a specific electronic magazine is generated for the user by combining disparate ones of the subsets of media content data based on both the tracked access and the user's authorization data.

Abstract: As may be implemented in accordance with one or more embodiments, respective sets of media content data, having disparate formats, are received from disparate content providers. The content is reformatted into a common format type and restructured into renditions having an article-oriented structure. Reformatted assets are generated for each rendition based upon characteristics of devices by which the renditions are to be accessed. Device-indeterminate ID linking data is generated for linking portions of each rendition with the media content data received from the content providers.

Abstract: A vascular occlusion device having an expandable frame that carries a membrane. The membrane can include a tubular portion configured to transition between an open configuration in which the tubular portion is configured to receive a guidewire and a closed configuration in which the tubular portion is configured to occlude blood flow.