Abstract: Methods, apparatuses and systems are described for expandable stent delivery apparatus to cover an access site. The method may include delivering the stent through an access site and deploying a distal portion of the stent from within an outer sheath. In some cases, the method may further include pushing a proximal portion of the stent from the outer sheath such that upon fully exiting the outer sheath, the proximal portion extends proximally to at least partially cover the access site with the stent. The system for delivering the stent into the body lumen may include a stent, a stent delivery apparatus, and an outer sheath. The system may further include an internal pusher configured to push a proximal portion of the stent from the outer sheath and axially compress the stent such that upon fully exiting the outer sheath, the proximal portion extends proximally to cover the access site.

Abstract: A chemical fluid for underground injection includes an inorganic substance, an antioxidant (e.g. ascorbic acid, gluconic acid, or a salt thereof, or ?-acetyl-?-butyrolactone, or bisulfite, or disulfite), and water. The inorganic substance may be a colloidal particle or a powder. The inorganic substance may be present in the chemical fluid in amounts of 0.001% by mass to 50% by mass based on the total mass of the chemical fluid for underground injection. The antioxidant may be present in the chemical fluid at a ratio of 0.0001 to 2 of the mass of the antioxidant to the mass of the inorganic substance. A surface of the inorganic substance may be coated with a silane compound. The chemical fluid may further include an anionic surfactant, a cationic surfactant, an amphoteric surfactant, a nonionic surfactant, or a mixture thereof.

Abstract: The present invention relates to processes for preparing linkers that are useful in the conjugation of therapeutic molecules (e.g., cytotoxic agents) with targeting moieties (e.g., proteins, peptides, antibodies, nanoparticles, nucleic acids). During said processes lipases like lipase B from Candida antarctica were used for enantioselective resolution of (S,S)-2-benzylthiocyclohexanol or (S,S)-2-benzylthiocycloheptanol in presence of acylating agent which are reduced for deprotection to yield (S,S)-2-mercaptocyclohexanol or (S,S)-2-mercaptocyclopentanol which can then be used for linking therapeutic with targeting moieties.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.

Abstract: The present invention relates to peptide conjugates of peptidic tubulin inhibitors (e.g., monomethyl auristatins) which are useful for the treatment of diseases such as cancer.

Abstract: An automated support system for local networks of connected devices has local network agents each comprising a digital processor, a memory, a local communications wireless interface for communicating locally with devices in the local network, and remotely with cloud-based servers. The servers include an interface for communicating with the local networks, and a recommendation engine programmed to dynamically communicate with the local network agents via the interface to capture support requests concerning devices and services, to perform work flow processing to generate a resolution for such support requests, and to communicate the resolution to the local network agent. The recommendation engine automatically generates a context for each support request, the context including historical resolution data for that local network, or device, or service.

Abstract: The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: An automated support system for local networks of connected devices has local network agents each comprising a digital processor, a memory, a local communications wireless interface for communicating locally with devices in the local network, and remotely with cloud-based servers. The servers include an interface for communicating with the local networks, and a recommendation engine programmed to dynamically communicate with the local network agents via the interface to capture support requests concerning devices and services, to perform work flow processing to generate a resolution for such support requests, and to communicate the resolution to the local network agent. The recommendation engine automatically generates a context for each support request, the context including historical resolution data for that local network, or device, or service.

Abstract: The present invention relates to peptide conjugates of microtubule-targeting agents such as maytansinoid derivatives which are useful for the treatment of diseases such as cancer.

Abstract: The present invention relates to peptide conjugates of cytotoxins such as topoisomerase I inhibitors which are useful for the treatment of diseases such as cancer.

Abstract: To generating a presentation of user activities occurring over a period of time, location history data that indicates multiple locations a user visited, along with the respective visit times, is received from the user. Using the location history data, a continuous event that begins on a first calendar day and ends on a second calendar day is determined. A representation of the first calendar day as a colloquial day is generated, where the colloquial day includes the entire event, and where the colloquial day at least partially overlaps with the calendar day but does no coincide with the calendar day. The colloquial day is displayed via a user interface.

Abstract: The present application relates to set top boxes and relates to the inclusion of a diagnostic function in the set top box which may be activated remotely or respond internally to the detection of faults or changes in status. The diagnostic function may emulate key presses from an infrared remote control to perform a test.

Abstract: The present application relates to set top boxes and relates to the inclusion of a diagnostic function in the set top box which may be activated remotely or respond internally to the detection of faults or changes in status. The diagnostic function may emulate key presses from an infrared remote control to perform a test.

Abstract: The present application relates to set top boxes and relates to the inclusion of a diagnostic function in the set top box which may be activated remotely or respond internally to the detection of faults or changes in status. The diagnostic function may emulate key presses from an infrared remote control to perform a test.