Patents by Inventor John P. Neenan

John P. Neenan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of analogs of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
    Patent number: 4266048
    Abstract: Analogs of 3'-phosphoadenosine 5'-phosphosulfate, also known as PAPS, are useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding an analog B of a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present process an analog B is selected from 8-bromoadenine, purine, hypoxanthine, 4-aminopyrrolo[2,3-d]pyrimidine (tubercidin), and 7-amino-pyrazolopyrimidine (formycin). In the pilot procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T.sub.2, the desired compound, an analog of PAPS, is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase II or spleen phosphodiesterase.
    Type: Grant
    Filed: October 26, 1978
    Date of Patent: May 5, 1981
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Jerome P. Horwitz, John P. Neenan, Radhey S. Misra, Jurij Rozhin, Anne Huo, Kerstin D. Philips, deceased
  • Facile synthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
    Patent number: 4169011
    Abstract: 3'-Phosphoadenosine 5'-phosphosulfate, also known as PAPS, is useful in establishing sulfate transfer mechanisms in animals and may be produced by a chemical process yielding 68-72% product from a pure adenosine 2',3'-cyclic phosphate 5'-phosphate, which compound is initially prepared from the reaction of adenosine and pyrophosphoryl chloride. In the present procedure the pure cyclic phosphate is reacted with triethylamine-N-sulfonic acid to produce 2',3'-cyclic phosphate 5'-phosphosulfate. Subsequently, by hydrolysis with the enzyme ribonuclease-T.sub.2, the desired compound is produced. Alternatively, the 2'-phosphoadenosine 5'-phosphosulfate, known as iso-PAPS, may be produced from 2',3'-cyclic phosphate 5'-phosphosulfate by treatment with a different enzyme, PDase or spleen phosphodiesterase. This latter compound, iso-PAPS, biologically has only one-third the activity of PAPS, the natural isomer.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: September 25, 1979
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: Jerome P. Horwitz, John P. Neenan, Radhey S. Misra, Jurij Rozhin, Anne L. Huo, Kirsten D. Philips, deceased
  • Anti herpes simplex viral compounds and their synthesis
    Patent number: 4000260
    Abstract: The compounds 5'-amino-2',5'-dideoxy-5-iodouridine; 5'-amino-2',5'-dideoxy-5-bromouridine; and the pharmaceutically acceptable acid addition salts thereof have been found to be potent inhibitors of herpes simplex virus.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: December 28, 1976
    Assignee: Research Corporation
    Inventors: H. William Prusoff, Yung-Chi Cheng, David C. Ward, John P. Neenan