Abstract: The invention relates to antibodies which treat diseases in which human IL-8, Gro-alpha, Gro-beta, Gro-gamma, GCP-2, and/or ENA-78 are implicated.

Abstract: The invention relates to antibodies which treat diseases in which human IL-8, Gro-alpha, Gro-beta, Gro-gamma, GCP-2, and/or ENA-78 are implicated.

Abstract: The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases

Abstract: Provided herein are isolated antigen binding protein comprising at least one first immunoglobulin variable domain capable of binding to human ADAMTS5. Also provided are antigen binding proteins of the present invention that are monoclonal antibodies, pharmaceutical compositions comprising said antigen binding proteins and methods of treatment.

Abstract: This invention relates to a pneumatic tire with puncture sealing property and a method for preparing such tire. Such tire is prepared by building an uncured butyl rubber-based layer, which contains a peroxide and a dispersion therein of a particulate precured rubber selected from pre resin-cured butyl rubber and/or pre sulfur-cured diene-based elastomer, into an uncured tire and between an innerliner layer and the tire carcass. Upon curing the prepared tire under conditions of elevated temperature, a major portion of the uncured butyl rubber composition is depolymerized to form a tacky material, which contains said dispersion therein of said particulate precured rubber, which has puncture sealant properties. Such layer of depolymerized butyl rubber and dispersed precured rubber particles may be collectively referred to as the sealant layer.

Abstract: The present invention is directed towards the hybrid combination of a drop gate injection molding system and a lattice gate. The lattice gate is located prior to the orifice of the drop gate. The lattice gate is comprised of a series of cross-direction flow channels through which the rubber flows, with mixing of the rubbers at the intersections of the flow channels. This hybrid molding system permits shorter cure times, and improved process cycle time for curing rubbers.

Abstract: The present invention is directed to the structure of an inline runner for injection molding which uniformly increases the temperature of the injected compound as the compound flows from the injection port to single or multiple drop gates at the entrance to single or multiple injection mold cavities. The inline runner has two opposing series of parallel channels formed into the runner for the purpose of mixing the compound as it flows through the runner.

Abstract: The present invention is directed to the structure of an inline runner for injection molding which uniformly increases the temperature of the injected compound as the compound flows from the injection port to single or multiple drop gates at the entrance to single or multiple injection mold cavities. The inline runner has two opposing series of parallel channels formed into the runner for the purpose of mixing the compound as it flows through the runner.

Abstract: This invention relates to a pneumatic tire with puncture sealing property and a method for preparing such tire. Such tire is prepared by building an uncured butyl rubber-based layer, which contains a peroxide and a dispersion therein of a particulate precured rubber selected from pre resin-cured butyl rubber and/or pre sulfur-cured diene-based elastomer, into an uncured tire and between an innerliner layer and the tire carcass. Upon curing the prepared tire under conditions of elevated temperature, a major portion of the uncured butyl rubber composition is depolymerized to form a tacky material, which contains said dispersion therein of said particulate precured rubber, which has puncture sealant properties. Such layer of depolymerized butyl rubber and dispersed precured rubber particles may be collectively referred to as the sealant layer.

Abstract: A tire mold has radially inner surfaces for forming a tread and a pair of sidewalls, the tire mold having at least one sidewall forming portion having a surface finish of less than 15 micro inches, preferably less than 10 micro inches. A tire produced in a tire mold has at least one sidewall having a surface gloss greater than 10 as measured using a 60-degree gloss reading per ASTM Designation D523-89.

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Abstract: The present invention is directed towards the hybrid combination of a drop gate injection molding system and a lattice gate. The lattice gate is located prior to the orifice of the drop gate. The lattice gate is comprised of a series of cross-direction flow channels through which the rubber flows, with mixing of the rubbers at the intersections of the flow channels. This hybrid molding system permits shorter cure times, and improved process cycle time for curing rubbers.

Abstract: The present invention is directed towards the hybrid combination of a drop gate injection molding system and a lattice gate. The lattice gate is located prior to the orifice of the drop gate. The lattice gate is comprised of a series of cross-direction flow channels through which the rubber flows, with mixing of the rubbers at the intersections of the flow channels. This hybrid molding system permits shorter cure times, and improved process cycle time for curing rubbers.

Abstract: Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.

Abstract: The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Abstract: The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Abstract: The invention relates to the method of preventing and treating sepsis and ARDS using chemokine &bgr;-4 or a biologically active fragment thereof, alone or in conjunction with an anti-infective agent.

Abstract: A combination rubber injection gate system (24) and method of injection molding rubber to produce desired flow patterns in the rubber is disclosed. The combination gate (24) directs rubber through a first region (26) to flow at cross angles (38, 40) through the injection gate (24), relative to the direction of flow of the rubber (22) through the injection gate (24). The rubber (22) is then directed through an adjacent region (28) to flow through the injection gate (24) at a direction parallel to the direction of flow of the rubber (22) through the entire injection gate (24). The combination gate (24) yields a highly mixed and uniform flow of rubber (22) that is particularly useful when injection molding fiber-loaded rubber where it is desired to orient the fibers in a particular direction.

Abstract: The present invention relates to a lattice gate for directing streams of rubber into an injection molding device through a plurality of intersecting channels (78, 80) which thermally mix the streams of rubber within the gate (76) as they pass through the intersections of the flow channels permitting the injection time of the rubber into the mold cavity to be decreased while simultaneously reducing the time for curing the rubber within the mold.

Abstract: The invention relates to the method of preventing and treating sepsis and ARDS using chemokine or biologically active fragment thereof, alone or in conjunction with an anti-infective agent.