Patents by Inventor John Robert Porter

John Robert Porter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thiocarboxamide derivatives
    Patent number: 6521626
    Abstract: Compounds of formula (1): wherein R1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Alk1 is an optionally substituted aliphatic or heteroaliphatic chain; L1 is a linker atom or group; r and s is each zero or an integer 1; R2 and R3, which may be the same or different, is each a hydrogen or halogen atom or a straight or branched alkyl, haloalkyl, alkoxy, haloalkoxy, hydroxyl or nitro group; Alk2 is a straight or branched alkylene chain; m is zero or an integer 1; R4 is a hydrogen atom or a methyl group; R5 is a hydrogen atom or a straight or branched alkyl group; R6 is a group —(CH2)tR7 in which t is zero or the integer 1 and R7 is an optionally substituted polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; R is a carboxylic acid (—CO2H) or a derivative thereof; and the salts, solvates and hydrates the
    Type: Grant
    Filed: March 23, 1999
    Date of Patent: February 18, 2003
    Assignee: Celltech R&D Limited
    Inventors: Sarah Catherine Archibald, John Clifford Head, Graham John Warrellow, John Robert Porter
  • Squaric acid derivatives
    Patent number: 6518283
    Abstract: Squaric acid Derivatives of formula (1) are described: wherein R1 is an integrin binding group; R2 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic chain; R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immune of inflammatory disorders, or disorders involving the inappropriate growth or migration of cells.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: February 11, 2003
    Assignee: Celltech R&D Limited
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow
  • 3-SUBSTITUTED ISOQUINOLIN-1-YL DERIVATIVES
    Publication number: 20020177605
    Abstract: Squaric acid derivatives of formula (1) are described: 1
    Type: Application
    Filed: August 1, 2001
    Publication date: November 28, 2002
    Inventors: John Clifford Head, Catherine McKay, John Robert Porter
  • 3-substituted isoquinolin-1-yl derivatives
    Patent number: 6469025
    Abstract: Squaric acid derivatives of formula (1) are described: wherein R1 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; Alk1 is an optionally substituted aliphatic chain; n is zero or the integer 1; R2 is a hydrogen atom or an optionally substitued heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group; Alk is a chain —CH2CH(R)—, —CH═C(R)—,  in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; Ar2 is an optionally substituted aromatic or heteroaromatic linking group; L2 is a covalent bond or a linker atom or group; R16 is the group —L3(Alk2)tL4R20 in which L3 and L4 which may be the same or different is each a covalent bond or a linker atom or group, t is zero or the integer 1, Alk2 is an optionally substituted aliphatic or heteroaliphatic chain and R20 is an optionally substituted
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: October 22, 2002
    Assignee: Celltech R&D Ltd.
    Inventors: John Clifford Head, Catherine McKay, John Robert Porter
  • Cinnamic acid derivatives
    Patent number: 6465471
    Abstract: Compounds of formula (1) are described: in which Het is a heteroaromatic group, Alk1 is an optionally substituted aliphatic or heteroaliphatic chain and R is a carboxylic acid or a derivative thereof. The compounds are able to inhibit the binding of &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: July 1, 1999
    Date of Patent: October 15, 2002
    Assignee: Celltech Therapeutics Limited
    Inventors: Graham John Warrellow, John Clifford Head, John Robert Porter, Sarah Catherine Archibald
  • 3-Substituted 2,7-naphthyridin-1-yl derivatives
    Publication number: 20020137935
    Abstract: 3-Substituted 2,7-naphthyridine derivatives of formula (1) are described: 1
    Type: Application
    Filed: November 27, 2001
    Publication date: September 26, 2002
    Inventors: John Clifford Head, Catherine McKay, John Robert Porter
  • Squaric acid derivates
    Patent number: 6455539
    Abstract: Squaric acid derivatives of formula (1) are described: wherein R1 is a group Ar1Ar2Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group; Ar2 is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH═C(R)—, in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6 alkyl group; L1 is a covalent bond or a linker atom or group; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic chain; R3 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloaliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group: and the salts, solvates, hydrates and N-oxides thereof.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: September 24, 2002
    Assignee: Celltech R&D Limited
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow
  • 2, 7-naphthyridine derivatives
    Publication number: 20020115684
    Abstract: 2,7-Naphthyridine containing squaric acids of formula (1) are described: 1
    Type: Application
    Filed: May 29, 2001
    Publication date: August 22, 2002
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow
  • Squaric acid derivatives
    Publication number: 20020107263
    Abstract: Squaric acid derivatives of formula (1) are described: 1
    Type: Application
    Filed: July 5, 2001
    Publication date: August 8, 2002
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow
  • Bicyclic enamide derivatives
    Publication number: 20020072607
    Abstract: Enamide derivatives of formula (1) are described: 1
    Type: Application
    Filed: September 5, 2001
    Publication date: June 13, 2002
    Inventors: Timothy John Norman, John Robert Porter, John Clifford Head, Andrew James Ratcliffe
  • 3-Substituted isoquinolin-1-yl derivatives
    Patent number: 6403608
    Abstract: 3-Substituted isoquinoline containing squaric acids of formula (1) are described: wherein Ar1 is a 3-substituted isoquinolin-1-yl group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted aromatic or heteroaromatic chain; Alk is a chain in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; R1 is a hydrogen atom or a C1-6alkyl group; L1 is a covalent bond or a linker atom or group; Alk1 is an optionally substituted aliphatic chain; n is zero or the integer 1; R2 is a hydrogen atom or an optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycycloalphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: June 11, 2002
    Assignee: Celltech R&D, Ltd.
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow
  • Pyridylalanine derivatives
    Patent number: 6369229
    Abstract: Aromatic amines of formula (1) are described: wherein Az is an optionally substituted monocyclic six-membered nitrogen-containing aromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; and R5 is a group —L2(CH2)tR6 in which L2 is a —N(R7)CO— or —N(R7)CS-group. The compounds are able to inhibit the binding of &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: April 9, 2002
    Assignee: Celltech Therapeutics, Limited
    Inventors: John Clifford Head, Graham John Warrellow, John Robert Porter, Sarah Catherine Archibald
  • Enamine derivatives
    Publication number: 20020037909
    Abstract: Enamine derivatives of formula (1) are described: 1
    Type: Application
    Filed: April 16, 2001
    Publication date: March 28, 2002
    Inventors: Timothy John Norman, John Robert Porter, Brian Woodside Hutchinson, Andrew James Ratcliffe, John Clifford Head, Rikki Peter Alexander, Barry John Langham, Graham John Warrellow, Sarah Catherine Archibald, Janeen Marsha Linsley
  • Phenylalanine derivatives
    Patent number: 6362204
    Abstract: Phenylalanine derivatives of formula (1) are described: wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; and R5 is a group —L2(CH2)tR6 in which L2 is a —N(R7)CO— or —N(R7)CS— group. The compounds are able to inhibit the binding &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: March 26, 2002
    Assignee: Celltech Therapeutics, Ltd
    Inventors: John Clifford Head, Sarah Catherine Archibald, Graham John Warrellow, John Robert Porter
  • Phenylalanine derivatives
    Publication number: 20020035127
    Abstract: Phenylalanine derivatives of formula (1) are described: 1
    Type: Application
    Filed: September 26, 2001
    Publication date: March 21, 2002
    Applicant: Celltech Therapeutis, Limited
    Inventors: John Clifford Head, Sarah Catherine Archibald, Graham John Warrellow, John Robert Porter
  • Phenylalanine derivatives
    Publication number: 20020028812
    Abstract: Phenylalanine derivatives of formula (1) are described: 1
    Type: Application
    Filed: August 10, 2001
    Publication date: March 7, 2002
    Inventors: John Clifford Head, John Robert Porter, Graham John Warrellow, Sarah Catherine Archibald, Brian Woodside Hutchinson
  • Phenylalanine derivatives
    Patent number: 6348463
    Abstract: Phenylalanine derivatives of formula (1) are described: in which: Ar1 is an aromatic or heteroaromatic group; L1 is a linker atom or group; R is a carboxylic acid or a derivative thereof; Ar2 is an optionally substituted aromatic or heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of &agr;4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: September 27, 1999
    Date of Patent: February 19, 2002
    Assignee: Celltech Therapeutics Limited
    Inventors: John Clifford Head, John Robert Porter, Graham John Warrellow, Sarah Catherine Archibald, Brian Woodside Hutchinson
  • Cinnamic acid derivatives
    Patent number: 6329362
    Abstract: Compounds of formula (1) are described: wherein L1 is a covalent bond or a linker atom or group; R is a carboxylic acid (—CO2H) or a derivative threof; R6 and R7 which may be the same or different is each an atom or group —L2(Alk2)tL3R12 in which L2, L3, Alk2 and t are as previously defined and R12 is a hydrogen or halogen atom or an —OR9, —NR9R10, —NO2, —CN, —CO2R9, —CONR9R10, —COR9, —N(R9)COR10, —N(R9)CSR10, —SO2N(R9)(R10), —N(R9)SO2R9, —N(R9)CON(R10)(R11), —N(R9)CSN(R10)(R11), —N(R9)SO2N(R10)(R11), or an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group provided that R6 and R7 are not both hydrogen atoms and when R7 is a hydrogen atom then R4 and R5 is each a hydrogen or halogen atom or an alkyl, alkoxy or nitro group; and the salts, solvates, hydrates and N-oxides thereof, for use in modulating cell adhesion.
    Type: Grant
    Filed: March 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Celltech Therapeutics Limited
    Inventors: Sarah Catherine Archibald, John Clifford Head, Graham John Warrellow, John Robert Porter
  • Phenylalanine derivatives
    Patent number: 6329372
    Abstract: Phenylalanine derivatives of formula (1) are described: wherein R is a carboxylic acid or a derivative thereof; L1 is a linker atom or group; Het is an optionally substituted heteroaromatic group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
    Type: Grant
    Filed: January 26, 1999
    Date of Patent: December 11, 2001
    Assignee: Celltech Therapeutics Limited
    Inventors: John Clifford Head, Sarah Catherine Archibald, Graham John Warrellow, John Robert Porter
  • Squaric acid derivatives
    Publication number: 20010020017
    Abstract: Squaric acid derivatives of formula (1) are described: 1
    Type: Application
    Filed: December 21, 2000
    Publication date: September 6, 2001
    Inventors: Barry John Langham, Rikki Peter Alexander, John Clifford Head, Janeen Marsha Linsley, John Robert Porter, Sarah Catherine Archibald, Graham John Warrellow