Patents by Inventor John S. Penn

John S. Penn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANOGOLD-DNA BIOCONJUGATES AND METHODS OF USE THEREOF
    Publication number: 20220233714
    Abstract: The present disclosure relates to nanoparticles and methods for detecting nucleic acids and methods of inhibiting mRNA expression.
    Type: Application
    Filed: January 27, 2022
    Publication date: July 28, 2022
    Inventors: MD Imam Uddin, John S. Penn, Gary W. McCollum
  • PROBES FOR DETECTING RNA AND METHODS OF USE THEREOF
    Publication number: 20220195500
    Abstract: The present disclosure relates to probes and methods for detecting nucleic acids, and for detecting and treating neovas-cularization.
    Type: Application
    Filed: April 24, 2020
    Publication date: June 23, 2022
    Inventors: Imam UDDIN, John S. PENN, Craig L. DUVALL
  • Composition and method for detecting hypoxia
    Patent number: 10695446
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: June 30, 2020
    Assignee: Vanderbilt University
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett
  • Composition and Method for Detecting Hypoxia
    Publication number: 20180085475
    Abstract: A compound and method for detecting hypoxic cells and tissue are provided. The compound includes a probe selected from the group consisting of a hypoxia sensitive 2-nitroimidazole containing fluorescence imaging probe, a hypoxia sensitive reversible ON-OFF fluorescence imaging probe, a hypoxia sensitive azo-based fluorescence imaging probe, and combinations thereof. The method includes contacting the cells or tissue with the probe of any one of claims 1-13 and detecting fluorescent intensity of the cell or tissue, wherein increased fluorescent intensity indicates that the cells or tissue is hypoxic. Also provided are a method of synthesizing the compound and a method for synthesizing a therapeutic agent including the compound.
    Type: Application
    Filed: May 2, 2016
    Publication date: March 29, 2018
    Inventors: Imam Uddin, Ashwath Jayagopal, Jashim Uddin, John S. Penn, Lawrence J. Marnett