Abstract: The invention provides new pyrazine derivatives of formula (I): or a tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined herein. The invention also provides pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.

Abstract: Disclosed implementations may include receiving a first communication comprising first content generated by a first user; identifying authentication metadata embedded within the first communication; receiving a second communication generated by a second user, wherein the second communication comprises second content and the authentication metadata; decoding the authentication metadata from the second communication; parsing the first content of the first communication and the second content of the second communication; determining that the first content is different than the second content based at least in part on the parsing; and generating an alteration notification based at least in part on the determining.

Abstract: In certain instances, a data management application (software application) that manages moving data files, and the like, from a primary high-speed storage system. An end-user can configure the data management application for particular files via management policies. Based on the management policies, after a file is migrated from the primary storage system to a targeted secondary storage system, a breadcrumb pointing to a webpage for the migrated file is left behind in the primary storage system. The webpage can be used to manage the migrated file, such as moving the migrated file back to the primary storage system.

Abstract: Systems and methods to enable 5G system support for conveying time synchronization are provided. In some embodiments, a method performed by a wireless device for conveying external time domain information is provided. The method includes receiving a message in a first time domain used by the wireless device, the message comprising external time domain information; determining information about a second time domain based on the external time domain information; and conveying information about the second time domain to another node. In some embodiments, timing information is included into a GPRS Tunneling Protocol (GTP) payload, and the wireless device can get timing information directly from the data payload. This minimizes the RAN and/or gNB impact and adds the potential for multiple time domain support.

Abstract: A method and a wireless device for determining out of order (OOO) operation are disclosed. According to one aspect, the processing circuitry is configured to, when at least one physical downlink shared channel (PDSCH) is subject to semi-persistent scheduling (SPS) determine an OOO condition that is independent of a relative timing of physical downlink control channel (PDCCH) signaling, the OOO condition being one of data transmission overlap and out-of-order hybrid automatic repeat request, HARQ, feedback. A method and wireless device for codebook construction are disclosed. According to one aspect, a method includes constructing a codebook by combining a first codebook and a second codebook, the first codebook being configured for hybrid automatic repeat request (HARQ) acknowledgment (ACK) response of dynamically scheduled physical shared channels and the second codebook being configured for HARQ-ACK response of semi-persistently scheduled (SPS) physical shared channels.

Abstract: A robot end effector (100) for dispensing an extrudable substance (102) comprises cartridge bays (122). Each one of the cartridge bays (122) is shaped to receive one of two-part cartridges (104). Each of the two-part cartridges (104) comprises a cartridge outlet (109). The robot end effector (100) also comprises a head assembly (150), comprising pairs of fittings (152). Each pair of the pairs of fittings (152) is configured to selectively supply compressed air from a pressure source (199) to contents of one of the two-part cartridges (104) when the two-part cartridges (104) are received by the cartridge bays (122) and the cartridge bays (122) are translated along a first axis (190) and along a second axis (192) so that the cartridge outlet (109) of the corresponding one of the two-part cartridges (104) is in fluidic communication with the mixer inlet (103).

Abstract: A robot end effector (100) for dispensing an extrudable substance (102) comprises a chassis (110), a static mixer (101), and cartridge bays (122), extending from the chassis (110). Each of the cartridge bays (122) is shaped to receive a corresponding one of the two-part cartridges (104). Fluidic communication between the selected one of the two-part cartridges (104) and the static mixer (101) is established when the cartridge bays (122) are rotated about an axis (190) to a predetermined orientation with respect to the chassis (110). The robot end effector (100) also comprises a dispensing valve (130), attached to the chassis (110), and a head assembly (150), comprising an inlet manifold (152). The inlet manifold (152) is configured to selectively supply compressed air from a pressure source (199) to contents of a corresponding one of the two-part cartridges (104).

Abstract: A robot end effector (100) for dispensing an extrudable substance (102) comprises a chassis (110), a static mixer (101), and cartridge bays (122), extending from the chassis (110). Each of the cartridge bays (122) is shaped to receive a corresponding one of the two-part cartridges (104). Fluidic communication between the selected one of the two-part cartridges (104) and the static mixer (101) is established when the cartridge bays (122) are moved to a predetermined position with respect to the chassis (110). The robot end effector (100) comprises a dispensing valve (130), attached to the chassis (110), and a head assembly (150), comprising pairs of fittings (152). Each of the pairs of fittings (152) is configured to selectively supply compressed air from a pressure source (199) to contents of a corresponding one of the two-part cartridges (104).

Abstract: A robot end effector for dispensing an extrudable substance comprises a chassis and cartridge bays, attached to the chassis and each shaped to receive a corresponding one of two-part cartridges. Robot end effector also comprises a dispensing valve, attached to the chassis and comprising a valve inlet and a valve outlet. The valve outlet is in selective fluidic communication with the valve inlet. Robot end effector further comprises a manifold, comprising a manifold outlet and manifold inlets, which are in fluidic communication with the manifold outlet. Robot end effector additionally comprises a plunger assembly, comprising pairs of plungers and arranged to concurrently extrude contents of the two-part cartridges through the cartridge outlets. Robot end effector also comprises an electric motor, attached to the chassis and configured to selectively move the plunger assembly relative to the chassis.

Abstract: An electronic communications method includes receiving, by a device, electronic information. The electronic communications method further includes receiving, by the device, additional electronic information. A time period between receiving the electronic information and the additional electronic information is less than another time period between receiving the electronic information and the additional electronic information by using a standard keyboard.

Abstract: Systems and methods to enable 5G system support for conveying time synchronization are provided. In some embodiments, a method performed by a wireless device for conveying external time domain information is provided. The method includes receiving a message in a first time domain used by the wireless device, the message comprising external time domain information; determining information about a second time domain based on the external time domain information; and conveying information about the second time domain to another node. In some embodiments, timing information is included into a GPRS Tunneling Protocol (GTP) payload, and the wireless device can get timing information directly from the data payload. This minimizes the RAN and/or gNB impact and adds the potential for multiple time domain support.

Abstract: A wireless device (e.g., UE) and a method implemented by the wireless device are described herein where the wireless device is configured with resources for both Physical Uplink Control Channel (PUCCH) and short PUCCH (sPUCCH), and determines whether or not the sPUCCH performance is equal to the PUCCH performance, and based on a result of the determination applies a strategy for determining when to trigger a fallback where the strategy is based on a number of failed Scheduling Request (SR) transmissions to a wireless access node (e.g., eNB, eNodeB, ng-eNB, gNB). A wireless access node and method implemented by the wireless access node are also described herein.

Abstract: Systems and methods related to conveying Time Sensitive Networking (TSN) synchronization information within a cellular communication system (e.g., a Fifth Generation System (5GS)) are disclosed. In one embodiment, a method performed by a User Equipment (UE) in a cellular communications system or a TSN Translator (TT) associated with the UE comprises receiving, from a TSN end station, a Precision Time Protocol (PTP) or generalized PTP (gPTP) announce message comprising information that identifies one or more clock domains for which the TSN end station desires to receive PTP or gPTP messages. The method further comprises sending, to a core network node in the cellular communications system, either: (a) the information that identifies the one or more clock domains extracted from the PTP or gPTP announce message or (b) the PTP or gPTP announce message. Using this information, UE specific PTP or gPTP message filtering may be applied.

Abstract: A method by a wireless device (110) includes receiving a first Downlink Semi-Persistent Scheduling (DL SPS) assignment and a second DL SPS assignment from a network node (160). At least one resource associated with the first DL SPS assignment and at least one resource associated with the second DL SPS assignment are at least partially overlapping. The wireless device compares priority information associated with each of the first DL SPS assignment and the second DL SPS assignment and selects a one of the first DL SPS assignment and the second DL SPS assignment that has a higher priority based on the priority information. The wireless device attempts to decode the Physical Downlink Shared Channel (PDSCH) according to the selected one of the first DL SPS assignment and the second DL SPS assignment that has the higher priority.

Abstract: A method performed by a wireless device includes receiving a first grant of resources from a network node. The first grant of resources is associated with first prioritization information. The wireless device constructs a Medium Access Control Protocol Data Unit, MAC PDU, based on the first grant. A second grant of resources that overlaps with the first grant of resources is received from the network node, and the second grant of resources is associated with second prioritization information. The wireless device determines whether to pre-empt transmission of the constructed MAC PDU based on comparing the first prioritization information and second prioritization information and pre-empts the transmission of the constructed MAC PDU if the second prioritization information indicates a higher priority than indicated by the first prioritization information.

Abstract: A Radio Network Node (RNN) and a method therein for providing improved robustness of a radio link between the RNN and a wireless device. The RNN and the wireless device operate in a communications network. The RNN transmits, towards the wireless device, a transmission with a first transmission mode associated with a first level of coverage extension. When a first period of time has elapsed, the RNN transmits, towards the wireless device, the transmission using a second transmission mode associated with a second level of coverage extension. The second level of coverage extension is higher than the first level of coverage extension.

Abstract: A method, system and apparatus are disclosed for a network node configured to communicate with a wireless device (WD). In some embodiments, the network node includes processing circuitry configured to cause the network node to determine delay offset information based at least in part on a common distance for a cell, the delay offset information indicating a common temporal delay offset and transmit the delay offset information to the WD in at least one of a system information block, SIB, and a radio resource control, RRC, message. In some embodiments, a wireless device includes processing circuitry configured to cause the wireless device to receive delay offset information in at least one of a system information block, SIB, and a radio resource control, RRC, message, the delay offset information being based at least in part on a common distance and the delay offset information indicating a common temporal delay offset.

Abstract: An exemplary power system utilizes turbines configured within a water intake conduit to the desalination processor to produce power for the desalination processor. Water intakes are configured to provide a natural flow of water to the desalination processor though hydrostatic pressure. One or more turbines coupled with the water intake conduits are driven and produce power for the system. The desalination processor incorporates Graphene filters to and may include a structured water system to increase the H3O2 concentration of the water prior to Graphene filters. Discharge water may be pumped back into the body of water but be separated from the intakes. A secondary power source, such as a renewable power source, may be used to produce supplemental power for the system. Power produced may be provided to a secondary outlet, such as a power grid, all above and/or underground.

Abstract: An exemplary power system utilizes turbines configured within a water intake conduit to the desalination processor to produce power for the desalination processor. Water intakes are configured to provide a natural flow of water to the desalination processor though hydrostatic pressure. One or more turbines coupled with the water intake conduits are driven and produce power for the system. The desalination processor incorporates Graphene filters to and may include a structured water system to increase the H3O2 concentration of the water prior to Graphene filters. Discharge water may be pumped back into the body of water but be separated from the intakes. A secondary power source, such as a renewable power source, may be used to produce supplemental power for the system. Power produced may be provided to a secondary outlet, such as a power grid, all above and/or underground.

Abstract: A wireless device (and method of) and a network node (and method of) are described herein for improving security for positioning without ciphering. In one embodiment, the wireless device is configured to: receive, from a network node, a paging request for a positioning event and a subsequent RRLP PDU; and perform, in response, an MTA procedure comprising a plurality of instances. When performing each instance, the wireless device transmits, to the network node, a RLC data block comprising at least a first field indicating a position of the instance in a sequence of the plurality of instances, and a second field indicating whether the instance is a last instance in the sequence of the plurality of instances. The network node upon receiving the RLC data block will be able to confirm whether the MTA procedure has been compromised by a fake wireless device.