Patents by Inventor Jon Zubieta
Jon Zubieta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090148382Abstract: One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.Type: ApplicationFiled: February 14, 2005Publication date: June 11, 2009Inventors: John W. Babich, William C. Eckelman, Kevin P. Maresca, John W. Valliant, Jon Zubieta
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Publication number: 20070098807Abstract: In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.Type: ApplicationFiled: May 15, 2006Publication date: May 3, 2007Inventors: John Babich, Jon Zubieta, Grant Bonavia
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Patent number: 7052913Abstract: In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.Type: GrantFiled: May 4, 2004Date of Patent: May 30, 2006Assignee: Molecular Insight Pharmaceuticals, Inc.Inventors: John W. Babich, Jon Zubieta, Grant Bonavia
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Publication number: 20060093552Abstract: One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluoresence and radioimaging for a variety of clinical diagnostic applications, as well as radiopharmaceuticals for therapeutic applications. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands that form a portion of the aforementioned complexes. Methods for the preparation of the technetium and rhenium complexes are also described. Another aspect of the invention relates to quinolinyl and isoquinolinyl ligands based on derivatized lysine, alanine and bis-amino acids for conjugation to small peptides by solid phase synthetic methods. Additionally, the invention relates to methods for imaging regions of a mammal using the complexes of the invention.Type: ApplicationFiled: February 14, 2005Publication date: May 4, 2006Applicant: Molecular Insight Pharmaceuticals, Inc.Inventors: John Babich, William Eckelman, Kevin Maresca, John Valliant, Jon Zubieta
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Publication number: 20040241205Abstract: In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.Type: ApplicationFiled: May 4, 2004Publication date: December 2, 2004Inventors: John W. Babich, Jon Zubieta, Grant Bonavia
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Publication number: 20030082238Abstract: In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.Type: ApplicationFiled: February 15, 2002Publication date: May 1, 2003Inventors: John W. Babich, Jon Zubieta, Grant Bonavia
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Patent number: 6395299Abstract: In one aspect, biocompatible matrices such as sol-gels encapsulating a reaction center may be administered to a subject for conversion of prodrugs into biologically active agents. In certain embodiments, the biocompatible matrices of the present invention are sol-gels. In one embodiment, the enzyme L-amino acid decarboxylase is encapsulated and implanted in the brain to convert L-dopa to dopamine for treatment of Parkinson's disease.Type: GrantFiled: February 14, 2000Date of Patent: May 28, 2002Assignee: Biostream, Inc.Inventors: John W. Babich, Jon Zubieta, Grant Bonavia
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Patent number: 6217845Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: November 6, 1997Date of Patent: April 17, 2001Assignee: AnorMed, Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5753520Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: February 6, 1995Date of Patent: May 19, 1998Assignee: Johnson Matthey Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5602266Abstract: A new class of vanadium phosphate materials using a mixed valence pentavanadate as the building block has been created using hydrothermal self-assembly techniques. These materials use a framework composed solely of V.sub.5 O.sub.9 (PO.sub.4).sub.4/2 pentamers and apart from the cationic template contain some of the largest voids and cavities yet reported in open framework solids.Type: GrantFiled: November 29, 1995Date of Patent: February 11, 1997Assignee: NEC Research Institute, Inc.Inventors: Robert C. Haushalter, Mohammad I. Khan, Linda M. Meyer, Jon A. Zubieta
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Patent number: 5420285Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species. The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: March 4, 1993Date of Patent: May 30, 1995Assignee: Johnson Matthey, Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giandomenico, Jon A. Zubieta
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Patent number: 5324848Abstract: A new class of vanadium phosphate materials has been created using hydrothermanl self-assembly techniques. Of particular interest is that these materials comprise a vanadium phosphate framework structure about an organic template that after removal leave a microporous structure. These materials typically are produced by a reaction in an aqueous solution that includes one or more phosphate sources, one or more vanadium or vanadium oxide sources, an alkali metal or alkali-earth metal sources, and an organic amine or diamine templating agent.Type: GrantFiled: March 11, 1993Date of Patent: June 28, 1994Assignee: NEC Research Institute, Inc.Inventors: Robert C. Haushalter, Victoria G. Soghomonian, Jon A. Zubieta
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Patent number: 5206370Abstract: Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.Type: GrantFiled: May 26, 1992Date of Patent: April 27, 1993Assignee: Johnson Matthey, Inc.Inventors: David A. Schwartz, Michael J. Abrams, Christen M. Giadomenico, Jon A. Zubieta