Patents by Inventor Jonathan Alan Medlock

Jonathan Alan Medlock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160185683
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Application
    Filed: December 18, 2013
    Publication date: June 30, 2016
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • Patent number: 9370772
    Abstract: The present invention relates to a new catalytic system, which is a Lindlar type catalyst, wherein the supporting material (CaCO3) has an average particle size (d50) of more than 10 Pm, as well as to the use of such a catalytic system for the partial hydrogenation of a carbon-carbon triple bond (to a carbon-carbon double bond).
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: June 21, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Axel Buss, Jonathan Alan Medlock, Thomas Mueller
  • Patent number: 9249074
    Abstract: The present invention relates to a new and improved synthesis of tetrahydromyrcenol (IUPAC name: 2,6-dimethyl-2-octanol).
    Type: Grant
    Filed: November 28, 2013
    Date of Patent: February 2, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Raphael Beumer, Werner Bonrath, Jonathan Alan Medlock
  • Publication number: 20150329451
    Abstract: The present invention relates to a new and improved synthesis of tetrahydromyrcenol (IUPAC name: 2,6-dimethyl-2-octanol).
    Type: Application
    Filed: November 28, 2013
    Publication date: November 19, 2015
    Applicant: DSM IP ASSETS B.V.
    Inventors: Raphael BEUMER, Werner BONRATH, Jonathan Alan MEDLOCK
  • Publication number: 20150329457
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimetylpentadecan-2-one in a multistep synthesis from 6,10-dimetylundec-5-en-2-one or 6,10-dimetylundeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 19, 2015
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, René Tobias STEMMLER, Johannes TSCHUMI, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • Publication number: 20150329456
    Abstract: The present invention relates to a process of manufacturing (6R,10R)-6,10,14-trimethylpentadecan-2-one in a multistep synthesis from a mixture of (5E,9E)-, (5E,9Z)-, (5Z,9E)- and (5Z.9Z)-isomers of 6,10,14-trimethylpentadeca-5,9,13-trien-2-one or 6,10,14-trimethylpentadeca-5,9-dien-2-one. The process is very advantageous in that it forms in an efficient way the desired chiral product from a mixture of stereoisomers of the starting product.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 19, 2015
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, René Tobias STEMMLER, Johannes TSCHUMI, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • Publication number: 20150321986
    Abstract: The present invention relates to a process of manufacturing compound having stereogenic centres from a mixture of E/Z isomers of unsaturated compounds having prochiral double bonds. The hydrogenation product has a specific desired configuration at the stereogenic centres. The process involves two asymmetric hydrogenation steps. The process is very advantageous in that it forms the desired chiral product from a mixture of stereoisomers of the starting product in an efficient way.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 12, 2015
    Inventors: Werner BONRATH, Thomas NETSCHER, Jonathan Alan MEDLOCK, René Tobias STEMMLER, Gerardus Karel Maria VERZIJL, Andreas Hendrikus Maria DE VRIES
  • Publication number: 20150321971
    Abstract: The present invention relates to a process of the asymmetric hydrogenation of an unsaturated ketone or aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex and in the presence of at least one additive and a halogenated alcohol. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 12, 2015
    Inventors: Jonathan Alan MEDLOCK, Gerardus Karel Maria VERZIJL, Edwin Gerard IJPEIJ, Andreas Hendrikus Maria DE VRIES
  • Publication number: 20150165431
    Abstract: The present invention relates to a new catalytic system, which is a Lindlar type catalyst, wherein the supporting material (CaCO3) has an average particle size (d50) of more than 10 Pm, as well as to the use of such a catalytic system for the partial hydrogenation of a carbon-carbon triple bond (to a carbon-carbon double bond).
    Type: Application
    Filed: June 21, 2013
    Publication date: June 18, 2015
    Inventors: Werner Bonrath, Axel Buss, Jonathan Alan Medlock, Thomas Mueller
  • Publication number: 20140357903
    Abstract: The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Application
    Filed: August 13, 2014
    Publication date: December 4, 2014
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Alan DYKE, Damian Mark GRAINGER, Jonathan Alan MEDLOCK, Hans Guenter NEDDEN, Jacques Jean Marie LE PAIH, Stephen James ROSEBLADE, Andreas SEGER, Vilvanathan SIVAKUMAR, Antonio ZANOTTI-GEROSA
  • Patent number: 8859815
    Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: October 14, 2014
    Assignee: Bial-Portela & C.A., S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • Patent number: 8680278
    Abstract: The present invention is directed to a process for enantioselectively preparing substituted piperidine alkanoic acid integrin antagonist compounds.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: March 25, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: William A. Kinney, Christopher A. Teleha, Shyamali Ghosh, Bruce E. Maryanoff, Gabriela Grasa, Antonio Zanotti-Gerosa, Jonathan Alan Medlock
  • Publication number: 20120123142
    Abstract: The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R1-10, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.
    Type: Application
    Filed: March 17, 2010
    Publication date: May 17, 2012
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Alan Dyke, Damian Mark Grainger, Jonathan Alan Medlock, Hans Guenter Nedden, Jacques Jean Marie Le Paih, Stephen James Roseblade, Andreas Seger, Vilvanathan Sivakumar, Antonio Zanotti-Gerosa
  • Publication number: 20120077973
    Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Application
    Filed: December 7, 2011
    Publication date: March 29, 2012
    Applicant: BIAL - PORTELA & CA, S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • Patent number: 7667075
    Abstract: A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: February 23, 2010
    Assignee: Bial - Portela & CA, S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • Publication number: 20090326274
    Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Application
    Filed: June 26, 2009
    Publication date: December 31, 2009
    Applicant: BIAL - PORTELA & CA, .S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
  • Patent number: 7601867
    Abstract: A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
    Type: Grant
    Filed: November 1, 2005
    Date of Patent: October 13, 2009
    Assignee: Bial-Portela & CA, S.A.
    Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock