Patents by Inventor Jonathan O'Halloran
Jonathan O'Halloran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11850593Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: GrantFiled: June 12, 2020Date of Patent: December 26, 2023Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
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Patent number: 11596944Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.Type: GrantFiled: October 15, 2018Date of Patent: March 7, 2023Assignee: QUANTUMDX GROUP LIMITEDInventors: Hojjat Madadi, Thomas Michael Willshare, Jonathan O'Halloran, Philip Thomas Scully, Paul Marshall, Eduardo Boada
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Publication number: 20210140951Abstract: The present invention relates to methods or assays for detecting proteins or molecules of interest in a sample. Aptamers specific to the protein of interest are obtained and are then incubated with the sample. If the protein of interest is present in the sample, protein-aptamer conjugates are formed. The incubated sample is then passed through a sorbent material designed to retain proteins and other cellular material whilst allowing free nucleic acid to flow through substantially unimpeded. If aptamer is detected in the output material at levels equivalent to the aptamer concentrations initially, this is indicative that no protein of interest was present in the sample, whereas if no (or potentially reduced) amounts of aptamer is detected in the flow through this is indicative of protein of interest in the sample as this will have bound to the aptamers and been retained by the sorbent material.Type: ApplicationFiled: March 6, 2018Publication date: May 13, 2021Inventors: Jonathan O'HALLORAN, Stephen OSBORNE, Henry STAINES
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Publication number: 20200298232Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.Type: ApplicationFiled: October 15, 2018Publication date: September 24, 2020Inventors: Hojjat MADADI, Thomas Michael WILLSHARE, Jonathan O'HALLORAN, Philip Thomas SCULLY, Paul MARSHALL, Eduardo BOADA
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Publication number: 20200298235Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: ApplicationFiled: June 12, 2020Publication date: September 24, 2020Inventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
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Patent number: 10759824Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: GrantFiled: January 4, 2016Date of Patent: September 1, 2020Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Joseph H. Hedley
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Patent number: 10710075Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: GrantFiled: June 20, 2017Date of Patent: July 14, 2020Assignee: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
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Publication number: 20190176151Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.Type: ApplicationFiled: June 20, 2017Publication date: June 13, 2019Applicant: QUANTUMDX GROUP LIMITEDInventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
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Patent number: 9938573Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: GrantFiled: August 4, 2016Date of Patent: April 10, 2018Assignee: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20170211136Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.Type: ApplicationFiled: March 27, 2017Publication date: July 27, 2017Inventor: Jonathan O'Halloran
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Patent number: 9605302Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.Type: GrantFiled: September 3, 2009Date of Patent: March 28, 2017Assignee: QuantuMDx Group LimitedInventor: Jonathan O'Halloran
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Publication number: 20170037463Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: ApplicationFiled: August 4, 2016Publication date: February 9, 2017Inventor: Jonathan O'Halloran
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Patent number: 9410196Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: GrantFiled: September 3, 2009Date of Patent: August 9, 2016Assignee: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20160139133Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: ApplicationFiled: January 4, 2016Publication date: May 19, 2016Inventors: Jonathan O'Halloran, Joseph H. Hedley
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Publication number: 20150276709Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of long individual polynucleotide molecules.Type: ApplicationFiled: August 5, 2013Publication date: October 1, 2015Applicant: QuantuMDx Group LimitedInventors: Jonathan O'Halloran, Christopher Adams, Joseph H. Hedley, Sam Whitehouse
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Publication number: 20150259731Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: ApplicationFiled: October 23, 2014Publication date: September 17, 2015Inventor: Jonathan O'Halloran
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Patent number: 8871921Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: GrantFiled: September 3, 2009Date of Patent: October 28, 2014Assignee: Quantumdx Group Ltd.Inventor: Jonathan O'Halloran
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Publication number: 20110294685Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.Type: ApplicationFiled: September 3, 2009Publication date: December 1, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20110165572Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.Type: ApplicationFiled: September 3, 2009Publication date: July 7, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran
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Publication number: 20110165563Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.Type: ApplicationFiled: September 3, 2009Publication date: July 7, 2011Applicant: QUANTUMDX GROUP LIMITEDInventor: Jonathan O'Halloran