Patents by Inventor Jonathan O'Halloran

Jonathan O'Halloran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200298235
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Application
    Filed: June 12, 2020
    Publication date: September 24, 2020
    Inventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
  • Publication number: 20200298232
    Abstract: A microfluidics device has one or more bubble diversion regions. Problems associated with the generation of air bubbles are avoided in a microfluidics device such as a cartridge, for use with a point of care (POC) diagnostics device, the cartridge being able to carry out downstream processing such as polymerase chain reaction (PCR) and/or nucleic acid capture. The bubble diversion region has a lower flow resistance than the flow resistance of an area of interest.
    Type: Application
    Filed: October 15, 2018
    Publication date: September 24, 2020
    Inventors: Hojjat MADADI, Thomas Michael WILLSHARE, Jonathan O'HALLORAN, Philip Thomas SCULLY, Paul MARSHALL, Eduardo BOADA
  • Patent number: 10759824
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: September 1, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Joseph H. Hedley
  • Patent number: 10710075
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: July 14, 2020
    Assignee: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'Halloran, Heather Murton, Stephen Osborne, Eduardo Boada, Jonathan Salmon
  • Publication number: 20200205894
    Abstract: A microwave ablation probe (200; 300; 400), comprising: an applicator (202; 302; 402) arranged to apply microwave radiation to heat surrounding tissue; a feeding cable (204; 304; 404) arranged to supply electromagnetic energy to the applicator; a coolant flow path (206) via which coolant is able to flow; and a choke arranged to reduce power reflected from the applicator (202; 302; 402) along the feeding cable (204; 304; 404). The choke comprises a choke member (208; 209; 308; 408) cooled by coolant flowing in the coolant flow path (206). The choke member (208; 209; 308; 408) extends between two points spaced apart in a direction having at least a component parallel to a longitudinal axis of the feeding cable. The choke member (208; 209; 308; 408) comprises one or more turns extending around the longitudinal axis of the feeding cable. The choke member may be a spiral member (208; 308; 408).
    Type: Application
    Filed: June 29, 2018
    Publication date: July 2, 2020
    Inventors: Jimmy EATON-EVANS, Giuseppe RUVIO, Martin O'HALLORAN, Jonathan BOUCHIER-HAYES, Mark BRUZZI
  • Publication number: 20200058106
    Abstract: Techniques for removing artefacts, such as RF interference and/or noise, from magnetic resonance data. The techniques include: obtaining input magnetic resonance (MR) data using at least one radio-frequency (RF) coil of a magnetic resonance imaging (MRI) system; and generating an MR image from input MR data at least in part by using a neural network model to suppress at least one artefact in the input MR data.
    Type: Application
    Filed: August 15, 2019
    Publication date: February 20, 2020
    Inventors: Carole Lazarus, Prantik Kundu, Sunli Tang, Seyed Sadegh Moshen Salehi, Michal Sofka, Jo Schlemper, Hadrien A. Dyvorne, Rafael O'Halloran, Laura Sacolick, Michael Stephen Poole, Jonathan M. Rothberg
  • Publication number: 20200034998
    Abstract: A magnetic resonance imaging (MRI) system, comprising: a magnetics system comprising: a B0 magnet configured to provide a B0 field for the MRI system; gradient coils configured to provide gradient fields for the MRI system; and at least one RF coil configured to detect magnetic resonance (MR) signals; and a controller configured to: control the magnetics system to acquire MR spatial frequency data using non-Cartesian sampling; and generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform data consistency processing using a non-uniform Fourier transformation.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 30, 2020
    Inventors: Jo Schlemper, Seyed Sadegh Moshen Salehi, Michal Sofka, Prantik Kundu, Ziyi Wang, Carole Lazarus, Hadrien A. Dyvorne, Laura Sacolick, Rafael O'Halloran, Jonathan M. Rothberg
  • Publication number: 20200033431
    Abstract: A magnetic resonance imaging (MRI) system, comprising: a magnetics system comprising: a B0 magnet configured to provide a B0 field for the MRI system; gradient coils configured to provide gradient fields for the MRI system; and at least one RF coil configured to detect magnetic resonance (MR) signals; and a controller configured to: control the magnetics system to acquire MR spatial frequency data using non-Cartesian sampling; and generate an MR image from the acquired MR spatial frequency data using a neural network model comprising one or more neural network blocks including a first neural network block, wherein the first neural network block is configured to perform data consistency processing using a non-uniform Fourier transformation.
    Type: Application
    Filed: July 29, 2019
    Publication date: January 30, 2020
    Inventors: Jo Schlemper, Seyed Sadegh Moshen Salehi, Michal Sofka, Prantik Kundu, Ziyi Wang, Carole Lazarus, Hadrien A. Dyvorne, Laura Sacolick, Rafael O'Halloran, Jonathan M. Rothberg
  • Publication number: 20190176151
    Abstract: Methods and devices for concentrating target cells using dielectrophoresis (DEP) are disclosed. The method allows relatively high throughput of sample through a microfluidic device in order to allow rapid capture of target cells even when they are present in low concentrations within the sample. The method utilizes multiple chambers through which samples will flow, the chambers arranged such that the first capture area has a larger area and faster flow rate than a second chamber, the second chamber being positioned downstream of the first capture area and being smaller with a slower flow rate to further concentrate the material captured in the first capture area.
    Type: Application
    Filed: June 20, 2017
    Publication date: June 13, 2019
    Applicant: QUANTUMDX GROUP LIMITED
    Inventors: Jonathan O'HALLORAN, Heather MURTON, Stephen OSBORNE, Eduardo BOADA, Jonathan SALMON
  • Patent number: 9938573
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: April 10, 2018
    Assignee: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20170211136
    Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.
    Type: Application
    Filed: March 27, 2017
    Publication date: July 27, 2017
    Inventor: Jonathan O'Halloran
  • Patent number: 9605302
    Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: March 28, 2017
    Assignee: QuantuMDx Group Limited
    Inventor: Jonathan O'Halloran
  • Publication number: 20170037463
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Application
    Filed: August 4, 2016
    Publication date: February 9, 2017
    Inventor: Jonathan O'Halloran
  • Patent number: 9410196
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic acid (DNA, RNA, cDNA, etc) molecules.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: August 9, 2016
    Assignee: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20160139133
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Application
    Filed: January 4, 2016
    Publication date: May 19, 2016
    Inventors: Jonathan O'Halloran, Joseph H. Hedley
  • Publication number: 20150276709
    Abstract: Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of long individual polynucleotide molecules.
    Type: Application
    Filed: August 5, 2013
    Publication date: October 1, 2015
    Applicant: QuantuMDx Group Limited
    Inventors: Jonathan O'Halloran, Christopher Adams, Joseph H. Hedley, Sam Whitehouse
  • Publication number: 20150259731
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Application
    Filed: October 23, 2014
    Publication date: September 17, 2015
    Inventor: Jonathan O'Halloran
  • Patent number: 8871921
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: October 28, 2014
    Assignee: Quantumdx Group Ltd.
    Inventor: Jonathan O'Halloran
  • Publication number: 20110294685
    Abstract: Embodiments of the present invention relate generally to strategies and methods of amplifying short target sequences and removing flanking sequences from target nucleic acids to remove background signal when detecting hybridizations events using sensitive detection biosensors, such as biosensors based on nanowires, carbon nanotubes, nanopores etc, that may be capable of detecting molecules at small molar concentrations (fM and less), or even at the single molecule level. Furthermore, by cropping and therefore standardizing the size of the target sequences to be detected, when detecting many target sequences in an array, the signals across each biosensor can be compared and the hybridization conditions standardized easily.
    Type: Application
    Filed: September 3, 2009
    Publication date: December 1, 2011
    Applicant: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran
  • Publication number: 20110165563
    Abstract: Embodiments of the present disclosure relate generally to reporter compositions which are synthetic nucleotides that comprise nucleotides with a high charge mass moiety attached thereto via a linker molecule. The linker molecules can vary in length in part to enable the high charge mass moiety to extend out from a DNA polymerase complex so that polymerization may not be influenced.
    Type: Application
    Filed: September 3, 2009
    Publication date: July 7, 2011
    Applicant: QUANTUMDX GROUP LIMITED
    Inventor: Jonathan O'Halloran