Patents by Inventor Joon Bok Lee

Joon Bok Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11986630
    Abstract: The exemplary embodiments attempt to identify impending hypoglycemia and/or hyperglycemia and take measures to prevent the hypoglycemia or hyperglycemia. Exemplary embodiments may provide a drug delivery system for delivering insulin and glucagon as needed by a user of the drug delivery system. The drug delivery system may deploy a control system that controls the automated delivery of insulin and glucagon to a patient by the drug delivery system. The control system seeks among other goals to avoid the user experiencing hypoglycemia or hyperglycemia. The control system may employ a clinical decision support algorithm as is described below to control delivery of insulin and glucagon to reduce the risk of hypoglycemia or hyperglycemia and to provide alerts to the user when needed. The control system assesses whether the drug delivery system can respond enough to avoid hypoglycemia or hyperglycemia and generates alerts when manual action is needed to avoid hypoglycemia or hyperglycemia.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: May 21, 2024
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Ashutosh Zade, Jason O'Connor, Trang Ly, Yibin Zheng, Connor Gullifer, Kyle Grover
  • Publication number: 20240157055
    Abstract: A drug delivery system including a memory storing programming code operable to enable delivery of insulin and a processor operable to execute the programming code. When executed, the programming code causes the processor to: calculate a first aggregate insulin-on-board amount for a user based on a plurality of individual insulin-on-board estimates made over a first period of time, determine that the first aggregate insulin-on-board amount is greater than a maximum depot formation threshold amount, determine a first residual amount of insulin remaining in the first aggregate insulin-on-board amount, increase a subsequent calculation of an individual insulin-on-board estimate based on the first residual amount of insulin, and utilize the subsequent calculation of the individual insulin-on-board estimate in a calculation of a second aggregate insulin-on-board amount over a second period of time.
    Type: Application
    Filed: November 14, 2023
    Publication date: May 16, 2024
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR, Ashutosh ZADE
  • Publication number: 20240157053
    Abstract: Invasive glucose sensors and noninvasive glucose sensors may be used in conjunction to improve glucose management for a user. The rate of change (ROC) of glucose levels from a noninvasive glucose sensor may be used rather than or in conjunction with a glucose level of the user from a CGM. A basal insulin delivery rate to the user may be adjusted responsive to the ROC glucose level data from the noninvasive sensor. The glucose level ROC from a noninvasive glucose sensor may be used to predict future glucose level ROCs of the user between operational cycles of an insulin delivery device and/or to identify possible hypoglycemic or hyperglycemic events. These predicted future glucose level ROCs may be used in a cost function of the control system of the insulin delivery device to select basal insulin delivery doses. Glucose level readings may be used to calibrate a noninvasive glucose level sensor.
    Type: Application
    Filed: October 31, 2023
    Publication date: May 16, 2024
    Inventors: Joon Bok LEE, John D’ARCO, Yibin ZHENG, Jason O’CONNOR, James CAUSEY, Ashutosh ZADE
  • Publication number: 20240148971
    Abstract: Exemplary embodiments may provide an on-body medicament delivery system that provides basal delivery of a medicament to a type 2 diabetes patient and that automatically performs medicament titration for the patient. The medicament delivery system performs medicament titration based on glucose level readings for the patient. These glucose levels may be provided wirelessly from a glucose sensor, such as a continuous glucose monitor, or may be entered manually by the patient into a management device, such as a smartphone running an application that provides a user interface for the patient to enter the glucose level readings. The medicament delivery system adjusts the basal medicament delivery rate/dose based on the glucose level readings for the patient. The adjustments may be performed by a programmatic mechanism, such as by computer programming instructions executing on a processor.
    Type: Application
    Filed: November 3, 2023
    Publication date: May 9, 2024
    Inventors: Matthew ALLES, Yibin ZHENG, Joon Bok LEE, James CAUSEY, Jason O'CONNOR
  • Publication number: 20240123141
    Abstract: Disclosed herein is a system and method for calculating an expected peak blood glucose level of user during a post-prandial period, based on a quantity of carbohydrates to be ingested. The user's expected peak blood glucose levels for slow, medium and fast acting carbohydrates are calculated. The results are presented to the user to allow the user to make an informed decision regarding the type of meal to be ingested.
    Type: Application
    Filed: October 6, 2023
    Publication date: April 18, 2024
    Inventors: Joon Bok LEE, James CAUSEY, John D’ARCO, Jason O'CONNOR
  • Patent number: 11957875
    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 16, 2024
    Assignee: INSULET CORPORATION
    Inventors: Yibin Zheng, Joon Bok Lee, Steven Cardinali, Jason O'Connor, Eric Benjamin, Ian McLaughlin, David Nazzaro, Ashutosh Zade
  • Publication number: 20240100253
    Abstract: Disclosed are techniques, devices and systems that provide adjustments to parameter settings of an insulin delivery algorithm based on inputs from a number of generic sensor devices. A majority of the generic sensor devices provide sensor readings that are unused as inputs to a drug deliver algorithm. The generic sensor devices may be operable to detect characteristics, such as changes in a state of a user. A processor may evaluate a sensor reading provided by a particular sensor with respect to a sensor baseline reading for the particular sensor. Using the result of the evaluation, the processor may calculate an adjustment to a parameter setting or settings of a medication delivery algorithm. A dosage of medication may be modified based on the adjustment of the parameter setting or settings.
    Type: Application
    Filed: September 13, 2023
    Publication date: March 28, 2024
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR, Ashutosh ZADE
  • Patent number: 11935637
    Abstract: Disclosed are a device, a computer-readable medium, and techniques that provide an onboarding process and an adaptivity process for a drug delivery device. A processor executing an onboarding process determines whether a history of delivered insulin to a user meets certain sufficiency requirements. The onboarding process enables a processor to cause the drug delivery device to administer doses of insulin to a user according to an initial total daily insulin dose calculation that is determined based on the sufficiency of the insulin delivery history. The initial total daily insulin may be adapted according to the adaptivity process as new insulin delivery is collected. The insulin delivery history, when sufficient, may be used to set total daily insulin dosages that enable automated insulin delivery upon replacement of a drug delivery device. The adaptivity process may be implemented to modify an initial insulin delivery doses to provide adapted insulin delivery doses.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: March 19, 2024
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Yibin Zheng, Jason O'Connor, Trang Ly, Eric Benjamin
  • Publication number: 20240079111
    Abstract: Disclosed herein is a method, implemented in an automatic drug delivery system, for determining insulin resistance of a user and adjusting parameters of the medication delivery algorithm of the automatic drug delivery system based on the determined insulin resistance. A self-guided test is administered similar to the Kraft test which determines if the quantity of insulin delivered during a post-prandial period after ingestion of a quantity of fast-acting carbohydrates is sufficient to lower the user's blood glucose level to a baseline level.
    Type: Application
    Filed: August 23, 2023
    Publication date: March 7, 2024
    Inventors: Joon Bok LEE, John D’ARCO, Jason O'CONNOR
  • Publication number: 20240075208
    Abstract: Disclosed herein is a system and method implementing a software-based method for detecting or confirming the detection of occlusions in the fluid path of an automatic drug delivery system. The invention uses real time glucose readings from a continuous glucose monitor in collaboration with past insulin delivery history and user indications of ingestion of carbohydrates, to determine cases where the user's glucose concentration is not being sufficiently impacted by the expected insulin delivery, which may indicate a significant pump site issue.
    Type: Application
    Filed: August 31, 2023
    Publication date: March 7, 2024
    Inventors: Joon Bok LEE, James CAUSEY, John D’ARCO, Jason O'CONNOR
  • Publication number: 20240075214
    Abstract: Safety and accuracy measures may be provided in a medicament delivery device. The medicament delivery device may be able to identify the inadvertent delivery of duplicate medicament boluses by a user. The exemplary embodiments may set limits for maximum allowable medicament bolus doses and maximum cumulative bolus doses over an interval. The exemplary embodiments may provide automatic meal detection and may use detection of meals in determining whether a user-requested medicament bolus dose should be adjusted or rejected. The exemplary embodiments may facilitate delivery of partial boluses and the delivery of remainders of the boluses contingent on acceptable glucose level trends of the user. The exemplary embodiments may resolve potential conflicts among multiple medicament delivery devices via a broker or by providing a single actor, such as a medicament delivery controller, that has sole control of dosing and delivery of medicament boluses.
    Type: Application
    Filed: August 15, 2023
    Publication date: March 7, 2024
    Inventors: Ashutosh ZADE, Joon Bok LEE, Yibin ZHENG, Rangarajan NARAYANASWAMI, Jason O’CONNOR
  • Publication number: 20240066213
    Abstract: Disclosed are techniques, devices and systems that modify an insulin delivery schedule based on how sensitive a diabetic user may to fluctuations in their total daily insulin or fluctuations in their blood glucose measurement values. As a control algorithm calculates how to adapt the calculation of the user's total daily insulin, a rate of adaptivity function may be used in the calculation. The rate of adaptivity may depend on a number of factors and the disclosed techniques, devices and systems enable calculation of the rate of adaptivity to provide effective implementation or modification of a diabetic treatment plan.
    Type: Application
    Filed: August 22, 2023
    Publication date: February 29, 2024
    Inventors: Joon Bok LEE, Jason O’CONNOR, Yibin ZHENG, Ashutosh ZADE
  • Publication number: 20240066224
    Abstract: Exemplary embodiments may apply a transform or filter to analyte level values of the users to make the analyte level values conform with a normal distribution that is symmetric relative to the mean. The transformed or filtered analyte level values may be used by the control system of a medicament delivery device in determining medicament delivery doses. In some embodiments, the medicament is insulin, and the analyte level is a glucose level of a user. In such instances, a logarithmic filter or transform may be applied to the glucose level readings of the user.
    Type: Application
    Filed: August 17, 2023
    Publication date: February 29, 2024
    Inventors: Yibin ZHENG, Joon Bok LEE, Jason O’CONNOR
  • Patent number: 11911596
    Abstract: Disclosed are techniques to establish initial settings for an automatic insulin delivery device. An adjusted total daily insulin (TDI) factor usable to calculate a TDI dosage may be determined. The adjusted TDI factor may be a TDI per unit of a physical characteristic of the user (e.g., weight) times a reduction factor. The adjusted TDI factor may be compared to a maximum algorithm delivery threshold. Based on the comparison result, the application or algorithm may set a TDI dosage and output a control signal. Blood glucose measurement values may be collected from a sensor over a period of time. A level of glycated hemoglobin of the blood may be determined based on the obtained blood glucose measurement values. In response to the level of glycated hemoglobin, the set TDI dosage may be modified. A subsequent control signal including the modified TDI dosage may be output to actuate delivery of insulin.
    Type: Grant
    Filed: March 20, 2023
    Date of Patent: February 27, 2024
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Mengdi Li, Jason O'Connor, Yibin Zheng
  • Publication number: 20240058534
    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide techniques to implement functionality to receive blood glucose measurements over a period of time. An average of missing blood glucose measurement values may be maintained over a predetermined time period. A count of a number of missing blood glucose measurement values over a period of time may be established. A controller may calculate a divergence of the number of missing blood glucose measurement values over the period of time from the average of missing blood glucose measurements over the predetermined time period. Based on a value of the divergence, a determination that a safety constraint for delivery of insulin is to be reduced. The safety constraint may be reduced by a predetermined percentage. An instruction to deliver an insulin dosage may be generated according to the reduced safety constraint may be forwarded to a wearable drug delivery device.
    Type: Application
    Filed: November 1, 2023
    Publication date: February 22, 2024
    Inventors: Joon Bok LEE, Jason O'CONNOR, Yibin ZHENG
  • Patent number: 11904140
    Abstract: The exemplary embodiments provide medicament delivery devices that use cost functions in their control systems to determine medicament dosages. The cost function may have a medicament cost component and a performance cost component. The exemplary embodiments may use cost functions having medicament cost components that scale asymmetrically for different ranges of inputs (i.e., different candidate medicament dosages). The variance in scaling for different input ranges provides added flexibility to tailor the medicament cost component to the user and thus provide better management of medicament delivery to the user and better conformance to a performance target. The exemplary embodiments may use a cost function that has a medicament cost component (such as an insulin cost component) of zero for candidate dosages for a range of candidate dosages (e.g., below a reference dosage).
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: February 20, 2024
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Yibin Zheng, Jason O'Connor, Trang Ly
  • Patent number: 11883632
    Abstract: Disclosed are a system, methods and computer-readable medium products that provide safety constraints for an insulin-delivery management program. Various examples provide safety constraints for a control algorithm-based drug delivery system that provides automatic delivery of a drug based on sensor input. Glucose measurement values may be received at regular time intervals from a sensor. A processor may predict future glucose values based on prior glucose measurement values. The safety constraints assist in safe operation of the drug delivery system during various operational scenarios. In some examples, predicted future glucose values may be used to implement safety constraints that mitigate under-delivery or over-delivery of the drug while not overly burdening the user of the drug delivery system and without sacrificing performance of the drug delivery system. Other safety constraints are also disclosed.
    Type: Grant
    Filed: January 25, 2023
    Date of Patent: January 30, 2024
    Assignee: INSULET CORPORATION
    Inventors: Jason O'Connor, Joon Bok Lee, Trang Ly, Yibin Zheng, Thomas Arnold Peyser, Jennifer Lena Schneider
  • Publication number: 20240009392
    Abstract: Exemplary embodiments may determine anticipated basal insulin delivery action to a user from an insulin delivery device over a future time window. Indications of the anticipated basal insulin delivery action over the future time window may be output to the user. The exemplary embodiments may determine the anticipated basal insulin delivery action over the future time window based on a rate of change (ROC) of glucose level of the user by the insulin delivery device, a most recent (“current”) glucose level for the user and insulin on board (IOB) for the user. The exemplary embodiments may also determine whether the user is likely to experience a undesired high glucose level (e.g., hyperglycemia) and/or an undesired low glucose level (e.g., hypoglycemia) during the future time window. The exemplary embodiments may output recommendations based on the projected glucose levels of the user over the future time window.
    Type: Application
    Filed: July 11, 2023
    Publication date: January 11, 2024
    Inventors: Joon Bok LEE, Joshua WILLIAMS, Jason O'CONNOR, Yibin ZHENG, Ashutosh ZADE
  • Publication number: 20240009393
    Abstract: Disclosed are a system, methods and computer-readable medium products that provide bolus dosage calculations by a control algorithm-based drug delivery system that provides automatic delivery of a drug, such as insulin or the like, based on sensor input. Blood glucose measurement values may be received at regular time intervals from a sensor. Using the blood glucose measurements, the control algorithm may perform various calculations and determinations to provide an appropriate bolus dosage. The appropriate bolus dosage may be used to respond to a trend in a trajectory of blood glucose measurements. In addition, a bolus dosage may also be determined by the disclosed device, system, method and/or computer-readable medium product in response to an indication that a user consumed a meal.
    Type: Application
    Filed: September 26, 2023
    Publication date: January 11, 2024
    Inventors: Steven CARDINALI, Joon Bok LEE, Jason O'CONNOR, Yibin ZHENG
  • Publication number: 20240000347
    Abstract: Disclosed herein is a method, implemented in an automated drug delivery system for determining a risk of a hypoglycemic or hyperglycemic condition based on risk factors calculated each time a new blood glucose reading is received and providing an alert to the user should a risk be determined. The risk factors may include the current CGM reading, the trend of CGM readings, the amount of insulin-on-board of the user and the accuracy of previous alerts provided to the user. The method may be modified to provide the risk of hypoglycemia if the user were to engage in exercise or other physical activities.
    Type: Application
    Filed: June 30, 2023
    Publication date: January 4, 2024
    Inventors: Jason O'CONNOR, Joon Bok LEE, Graeme NELSON