Patents by Inventor Joon Bok Lee

Joon Bok Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220379029
    Abstract: Provided is a wearable medical device that includes a processor or logic circuitry. The wearable medical device may include a memory storing instructions that, when executed by the processor or logic circuitry, configure the wearable medical device to determine, by the processor or the logic circuitry, that an event affecting a blood glucose measurement value trend of a user has occurred. Based on the occurrence of the event, the processor or the logic circuitry may select a mode of operation of the analyte sensor, and generate a signal indicating the selected mode of operation. The mode of operation may correspond to a sampling frequency of a physical attribute or physiological condition of a user of the wearable medical device.
    Type: Application
    Filed: May 25, 2022
    Publication date: December 1, 2022
    Inventors: Ashutosh ZADE, Joon Bok LEE, Yibin ZHENG
  • Publication number: 20220361812
    Abstract: The disclosed embodiments are directed to systems and methods for providing optimized, individualized bolus dosing of insulin based on a macronutrient profile of meals ingested by the patient. Optimized bolus dosing may be provided by varying the overall quantity of insulin delivered in the post-prandial window, as well as the split between a portion of the insulin delivered immediately after the meal and a portion of the insulin delivered later in the post-prandial window, based on an analysis of the macronutrient profile of the meal and the behavior of the blood glucose trace of the patient from past meals.
    Type: Application
    Filed: May 4, 2022
    Publication date: November 17, 2022
    Inventors: Rangarajan NARAYANASWAMI, Yibin ZHENG, Jay JANTZ, Joon Bok LEE
  • Publication number: 20220347386
    Abstract: Disclosed are processes and techniques implementable by a drug delivery system to maintain optimal drug delivery for a patient according to a treatment plan. The disclosed techniques enable a new drug delivery device that is exchanged for a previous drug delivery device to operate using analyte-based drug delivery control immediately during initialization instead of having to wait for a warm-up period. For example, a drug delivery device may include a processor and a memory storing instructions that, when executed by the processor, operate the drug delivery device to receive a present analyte measurement value from an analyte sensor during an initialization of the drug delivery device, receive backfill values measured by the analyte sensor prior to the initialization, calculate a dosage of a drug using the present analyte measurement value and the backfill values, and deliver the dosage of the drug. Other embodiments are described.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 3, 2022
    Inventors: Ashutosh ZADE, Joon Bok LEE, Yibin ZHENG
  • Publication number: 20220331519
    Abstract: Exemplary embodiments may compensate for loss of calibration by sensors that provide sensed analyte measurements to delivery devices. The exemplary embodiments may obtain one or more calibrated analyte measurements, such as by using techniques to obtain that the analyte measurement value that are known to produce properly calibrated analyte values. The one or more calibrated analyte measurements are compared to a recent analyte measurement to determine a negative or positive offset. The offset may be added to the recent analyte measurement to generate an updated analyte measurement that reflects the calibrated analyte measurement. In addition, past analyte measurement values within a time window may be updated as well by adding the offset to the past analyte measurement values. The exemplary embodiments may also compensate for the past over-delivery or under-delivery of an agent by the delivery device due to the loss of calibration.
    Type: Application
    Filed: April 12, 2022
    Publication date: October 20, 2022
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR, Ashutosh ZADE
  • Publication number: 20220331520
    Abstract: Disclosed are a system, a device, processes, techniques and computer-readable media that set an insulin adjustment factor that is applied to a dose of a therapeutic exogenous substance. The adjustment factor accounts for production of endogenous insulin related to the therapeutic exogenous substance. A processor of an automatic drug delivery device may determine and administer the doses of the therapeutic exogenous substance according to a process in which an amount of a therapeutic exogenous substance to deliver is estimated. An insulin adjustment factor utilizing an estimated relative therapeutic exogenous substance concentration may be determined. The processor may calculate a compensating dose of the therapeutic exogenous substance based on the estimated amount of the therapeutic exogenous substance to deliver that is modified by the insulin adjustment factor. The compensating dose of the therapeutic exogenous substance may be expelled from a reservoir by a pump mechanism.
    Type: Application
    Filed: April 19, 2022
    Publication date: October 20, 2022
    Inventors: Joon Bok Lee, Yibin Zheng, Jason O'Connor
  • Publication number: 20220288300
    Abstract: The exemplary embodiments provide medicament delivery devices that use cost functions in their control systems to determine medicament dosages. The cost function may have a medicament cost component and a performance cost component. The exemplary embodiments may use cost functions having medicament cost components that scale asymmetrically for different ranges of inputs (i.e., different candidate medicament dosages). The variance in scaling for different input ranges provides added flexibility to tailor the medicament cost component to the user and thus provide better management of medicament delivery to the user and better conformance to a performance target. The exemplary embodiments may use a cost function that has a medicament cost component (such as an insulin cost component) of zero for candidate dosages for a range of candidate dosages (e.g., below a reference dosage).
    Type: Application
    Filed: May 25, 2021
    Publication date: September 15, 2022
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR, Trang LY
  • Publication number: 20220288311
    Abstract: Exemplary embodiments may modify the cost function parameters based on current and projected mean outcomes in blood glucose level control performance. The exemplary embodiments may modify the weight coefficient R for the insulin cost so that the value of R is not fixed and is not based solely on clinical determined values. Exemplary embodiments may also adjust the cost function to address persistent low-level blood glucose level excursions for users. The exemplary embodiments may reduce the penalty of the insulin cost by the sum of the converted insulin cost of the glucose excursions above target for a period divided by a number of cycles of average insulin action time. The AID system reduces the insulin cost by the lack of insulin in previous cycles.
    Type: Application
    Filed: March 7, 2022
    Publication date: September 15, 2022
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR
  • Publication number: 20220293234
    Abstract: The exemplary embodiments may modify a glucose cost component of the cost function of the control loop of an insulin delivery device to compensate for persistent positive low level glucose excursions relative to a target glucose level. The exemplary embodiments may enable use of different glucose cost component functions for different glucose levels of the user. These glucose cost component functions may be employed in piecewise fashion with a different piece being applied for each respective range of glucose level values for the user. The final glucose cost function for calculating the glucose cost component may be a weighted combination of a piecewise glucose cost function and a weighted standard cost function (such as a quadratic function). The weights may reflect the magnitude and/or persistence of glucose excursions relative to a target glucose level.
    Type: Application
    Filed: March 10, 2022
    Publication date: September 15, 2022
    Inventors: Joon Bok LEE, Eric BENJAMIN, Jason O'CONNOR, Yibin ZHENG
  • Publication number: 20220287633
    Abstract: Disclosed are processes and techniques implementable by devices and a drug delivery system to maintain optimal drug delivery for a user according to a user's diabetes treatment plan. The disclosed techniques enable a drug delivery device that received an analyte measurement value from an analyte sensor during a prior cycle time to determine a present analyte measurement value has not been received during a present cycle time. A processor of the drug delivery device may, in response to the determination, initiate an action to obtain the present analyte measure value from another device or an estimate of the present analyte measurement value. Based on an outcome of the initiated action, the processor may calculate a dosage of the drug using the present analyte measurement value or information related to the present analyte measurement value. The drug delivery device may also be operable to output the calculated dosage of the drug.
    Type: Application
    Filed: March 3, 2022
    Publication date: September 15, 2022
    Inventors: Yibin ZHENG, Ashutosh ZADE, Joon Bok LEE
  • Patent number: 11439754
    Abstract: Disclosed herein is a method for execution by a drug delivery device for determining an optimal dose of a liquid drug for current cycle of a medication delivery algorithm, the method utilizing a stepwise evaluation of a model and a cost function across a coarse search space consisting of coarse discrete quantities of the drug and a refined search space consisting of refined discrete quantities of the drug.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: September 13, 2022
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Yibin Zheng, Jason O'Connor, Ashutosh Zade
  • Publication number: 20220280721
    Abstract: Exemplary embodiments provide more customized basal insulin amounts for users to better regulate blood glucose (BG) concentration levels. The exemplary embodiments do not statically assume that the daily basal amount for each user is 50% of TDI. Instead, actual TDI data may be gathered for each user and may be used to adjust the TDI value for that user to an updated value. In addition, the ratio of basal to TDI may be adjusted for the user based on the actual ratio determined from data gathered over one or more days. As a result, better BG concentration level control may be realized.
    Type: Application
    Filed: March 2, 2022
    Publication date: September 8, 2022
    Inventors: Joon Bok LEE, Yibin ZHENG, Jason O'CONNOR
  • Publication number: 20220249773
    Abstract: Disclosed are techniques, a system and devices that enable the setting of an upper boundary constraint that may be a multiple of a total daily dosage setting for a liquid drug being administered to a user to control a condition, such as type 1 or type 2 diabetes mellitus. An automatic drug delivery algorithm may be configured to obtain a glucose control metric. A controller executing the automatic drug delivery algorithm may ascertain, based on the glucose control metric, an upper boundary constraint for the liquid drug that limits an amount of a dose of the liquid drug that may be delivered by the automatic drug delivery system or components thereof.
    Type: Application
    Filed: February 4, 2022
    Publication date: August 11, 2022
    Inventors: Yibin ZHENG, Joon Bok LEE, Jason O'CONNOR
  • Publication number: 20220241503
    Abstract: The disclosed examples provide techniques and devices for determining a daily basal profile or an adjusted basal need for a drug based on a collection of data that is filtered and processed. A controller may be configured to evaluate a history of drug delivery in both basal and bolus dosages and generate a daily basal profile or an adjusted basal need that is a time dependent that may be used to schedule basal dosages of a drug that more closely addresses a user's drug needs over the course of a time period, such as a day, week or the like.
    Type: Application
    Filed: January 19, 2022
    Publication date: August 4, 2022
    Inventors: Yibin ZHENG, Joon Bok LEE
  • Publication number: 20220240847
    Abstract: Disclosed herein are systems and methods for the delivery of insulin and pramlintide using an automated insulin delivery system. In a first embodiment, a drug delivery system is configured to deliver independent doses of insulin and pramlintide. The system monitors the user's blood glucose level and determines when a meal is been ingested and, in response, delivers the dose of pramlintide which, in turn alters the required delivery of insulin. In the second embodiment, the drug delivery system is configured to deliver a co-formulation of insulin and pramlintide as basal doses. The total amount of pramlintide delivered in a most recent pre-determine period of time, for example, 24 hours, is used to alter the aggressiveness of the algorithm which determines the basal doses of the co-formulation.
    Type: Application
    Filed: January 24, 2022
    Publication date: August 4, 2022
    Inventors: Joon Bok LEE, Jason O'CONNOR, Yibin ZHENG, Ashutosh ZADE
  • Publication number: 20220241504
    Abstract: Disclosed herein are systems and methods for the delivery of a co-formulation of insulin and a second drug, such as GLP-1, using an automated insulin delivery system. In a first embodiment, a dose of insulin is calculated by a medication delivery algorithm and a reduction factor is applied to account for the effect of second drug on the user's daily insulin requirement. In a second embodiment of the invention, a total amount of the second drug administered to the user during the past 24 hours is used to modify the correction factor and the insulin-to-carbohydrate ratio used by the medication delivery algorithm to cause a reduction in the insulin delivered to the user to account for the effect of the administration of the second drug portion of the co-formulation.
    Type: Application
    Filed: January 24, 2022
    Publication date: August 4, 2022
    Inventors: Joon Bok LEE, Jason O'CONNOR, Yibin ZHENG, Ashutosh ZADE
  • Publication number: 20220226576
    Abstract: Exemplary embodiments may address the problem of missing blood glucose concentration readings from a glucose monitor that transmits blood glucose concentration readings over a wireless connection due to problems with the wireless connection. In the exemplary embodiments, an automated insulin delivery (AID) device uses an estimate in place of a missing blood glucose concentration reading in determining a predicted future blood glucose concentration reading for a user. Thus, the AID device is able to operate normally in generating insulin delivery settings despite not receiving a current blood glucose concentration reading for a current cycle. There is no need to suspend delivery of insulin to the user due to the missing blood glucose concentration reading.
    Type: Application
    Filed: April 7, 2022
    Publication date: July 21, 2022
    Inventors: Yibin ZHENG, Joon Bok LEE, Ashutosh ZADE, Jason O'CONNOR
  • Patent number: 11383035
    Abstract: Disclosed herein is a method for execution by a drug delivery device for determining an optimal dose of a liquid drug for current cycle of a medication delivery algorithm, the method utilizing a stepwise evaluation of a model and a cost function across a coarse search space consisting of coarse discrete quantities of the drug and a refined search space consisting of refined discrete quantities of the drug.
    Type: Grant
    Filed: December 1, 2021
    Date of Patent: July 12, 2022
    Assignee: INSULET CORPORATION
    Inventors: Joon Bok Lee, Yibin Zheng, Jason O'Connor, Ashutosh Zade
  • Publication number: 20220203023
    Abstract: A system for automatically delivering medication to a user is disclosed. A sensor worn by the user can collect information regarding the user. A user device, for example, a smartphone, executes a user application that uses the collected information to determine an amount of medication to provide to the user. The user application includes a graphical user interface that allows the user to easily interact with the user application to specify various aspects of the delivery of the medication. The user application controls a wearable drug delivery device to dispense the medication to the user.
    Type: Application
    Filed: October 29, 2021
    Publication date: June 30, 2022
    Inventors: Jason O'CONNOR, Joon Bok LEE, David NAZZARO, Yibin ZHENG, Pauline TANDON
  • Publication number: 20220193337
    Abstract: The exemplary embodiments may provide a smartwatch or a vehicle infotainment system with management and data inspection capabilities for a medicament delivery system. A user may view medicament delivery history and analyte level history via the smartwatch or auto mobile infotainment system. In addition, a user may calculate a medicament dosage and prompt delivery of the medicament bolus dosage via the smartwatch or vehicle infotainment system. Notifications also may be delivered to the user via the smartwatch and vehicle infotainment system.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Inventors: Matthew ALLES, Joon Bok LEE
  • Publication number: 20220199215
    Abstract: Exemplary embodiments may enable a user to schedule medicament bolus deliveries, such as insulin boluses, for future dates and times. The exemplary embodiments may provide the ability to delay a scheduled medicament bolus delivery by short periods of time. The user may reschedule a scheduled medicament bolus delivery by entering a new date and/or time for the medicament bolus delivery. Still further, a user may cancel a scheduled medicament bolus delivery. In addition, exemplary embodiments may enable multiple medicament bolus deliveries to be viewed and managed.
    Type: Application
    Filed: December 17, 2021
    Publication date: June 23, 2022
    Inventors: Matthew ALLES, Daniel MURRAY, Joon Bok LEE, Jason O'CONNOR