Patents by Inventor Joost Dick de Bruijn
Joost Dick de Bruijn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230158213Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: ApplicationFiled: January 25, 2023Publication date: May 25, 2023Inventors: Huipin Yuan, Joost Dick de Bruijn
-
Patent number: 11590263Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: GrantFiled: December 5, 2019Date of Patent: February 28, 2023Assignee: NuVasive Netherlands B.V.Inventors: Huipin Yuan, Joost Dick de Bruijn
-
Patent number: 10836986Abstract: A bioreactor system (1A; 1B) includes a variable volume container (3) having a flexible outer wall (27, 29) defining a cell-culture chamber for containing a fluid culture medium, and anchorage dependent cells in suspension. A agitator unit of the system (1A; 1B) is in fluid communication with first, second and third fluid ports (43, 45, 47A; 47B) for performing controlled replenishment of the culture medium in the cell-culture chamber, to admit fresh nutritive culture medium into the cell-culture chamber and for allowing draining of waste culture medium from the cell-culture chamber. The agitator unit further has a roller (15) for pinching the outer wall of the variable volume container (3) to thereby increase its a volume that forms the cell-culture chamber, starting from the initial minimum volume area (23), and means for gently agitating the cell-culture chamber.Type: GrantFiled: July 18, 2014Date of Patent: November 17, 2020Assignee: SCINUS CELL EXPANSION B.V.Inventors: Emerentius Gerardus Roosloot, Rudolf Hendrikus Jozef Das, Joost Dick De Bruijn, Pieter Theo Elias Van Santen
-
Publication number: 20200108180Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: ApplicationFiled: December 5, 2019Publication date: April 9, 2020Inventors: Huipin Yuan, Joost Dick de Bruijn
-
Patent number: 10532131Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: GrantFiled: July 6, 2015Date of Patent: January 14, 2020Assignee: NuVasive Netherlands B.V.Inventors: Huipin Yuan, Joost Dick de Bruijn
-
Publication number: 20160152935Abstract: A bioreactor system (1A; 1B) includes a variable volume container (3) having a flexible outer wall (27, 29) defining a cell-culture chamber for containing a fluid culture medium, and anchorage dependent cells in suspension. A agitator unit of the system (1A; 1B) is in fluid communication with first, second and third fluid ports (43, 45, 47A; 47B) for performing controlled replenishment of the culture medium in the cell-culture chamber, to admit fresh nutritive culture medium into the cell-culture chamber and for allowing draining of waste culture medium from the cell-culture chamber. The agitator unit further has a roller (15) for pinching the outer wall of the variable volume container (3) to thereby increase its a volume that forms the cell-culture chamber, starting from the initial minimum volume area (23), and means for gently agitating the cell-culture chamber.Type: ApplicationFiled: July 18, 2014Publication date: June 2, 2016Applicant: XPAND BIOTECHNOLOGY B.V.Inventors: Emerentius Gerardus ROOSLOOT, Rudolf Hendrikus Jozef DAS, Joost Dick DE BRUIJN, Pieter Theo Elias VAN SANTEN
-
Publication number: 20160067382Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: ApplicationFiled: July 6, 2015Publication date: March 10, 2016Inventors: Huipin Yuan, Joost Dick de Bruijn
-
Patent number: 9272071Abstract: The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c.Type: GrantFiled: May 27, 2009Date of Patent: March 1, 2016Assignee: REVISIOS B.V. I.O.Inventors: Davide Barbieri, Huipin Yuan, Joost Dick De Bruijn
-
Patent number: 8809054Abstract: The present invention is directed to a method to expand adherent cells comprising addition of adherent cells to an expansion container comprising microcarriers and culture medium; removing medium from the expansion container through a 8-20 mm filter; allowing cells to attach to microcarriers and keeping the expansion container in motion with an angle of between 30 to 90° and ?30 to ?90°. The present invention is also directed to a device suitable in the method. The advantage of the present invention is that fewer steps are needed to expand adherent cells, including stem cells like MSC opening the way for the use of autologeous and allogenous stem cell therapy. In addition, contamination risk is limited since the present invention may be carried out in a closed, disposable system.Type: GrantFiled: May 11, 2011Date of Patent: August 19, 2014Assignee: Xpand Biotechnology B.V.Inventors: Elise Leonore Isolde Dijkhuizen Borgart, Madelon Sophia George Maria Bracke, Joost Dick De Bruijn
-
Publication number: 20130157353Abstract: A cell-culture-bag for use in the expansion of stem cells from a crude biopsy, comprising: outer walls; a chamber located within the walls; a first inlet, and first and second outlets, providing fluid communication with the chamber, for connection to a perfusion apparatus; and a filter arrangement constructed to allow passage of red blood cells and block passage of stem cells from the first outlet, and block passage of microcarriers from the second outlet.Type: ApplicationFiled: May 11, 2011Publication date: June 20, 2013Applicant: XPAND BIOTECHNOLOGY B.V.Inventors: Elise Leonore Isolde Dijkhuizen Borgart, Madelon Sophia George Maria Bracke, Joost Dick De Bruijn
-
Patent number: 8460685Abstract: The invention relates to methods of improving the osteoinductivity of calcium phosphate materials, to calcium phosphate materials having improved osteoinductivity as well as bone (re)generation scaffolds produced therefrom and to the use of such materials and scaffolds in methods of treatment.Type: GrantFiled: April 21, 2006Date of Patent: June 11, 2013Assignee: Progentix Orthobiology B.V.Inventors: Huipin Yuan, Joost Dick De Bruijn, Klaas De Groot
-
Publication number: 20130059383Abstract: The present invention is directed to a method to expand adherent cells comprising addition of adherent cells to an expansion container comprising microcarriers and culture medium; removing medium from the expansion container through a 8-20 mm filter; allowing cells to attach to microcarriers and keeping the expansion container in motion with an angle of between 30 to 90° and ?30 to ?90°. The present invention is also directed to a device suitable in the method. The advantage of the present invention is that fewer steps are needed to expand adherent cells, including stem cells like MSC opening the way for the use of autologeous and allogenous stem cell therapy. In addition, contamination risk is limited since the present invention may be carried out in a closed, disposable system.Type: ApplicationFiled: May 11, 2011Publication date: March 7, 2013Inventors: Elise Leonore Isolde Dijkhuizen Borgart, Madelon Sophia George Maria Bracke, Joost Dick De Bruijn
-
Publication number: 20120021008Abstract: Disclosed is an injectable and moldable ceramic material comprising porous calcium phosphate having surface-microporosity, and a water-free carrier, wherein the carrier is selected so as to disintegrate under physiological circumstances. The latter refers to the property of a carrier to dissolve, disassociate, or otherwise disintegrate after placement (e.g. through injection or implantation) into the human body. By selection of a water-free polymer or polymer blend which is combined with surface-microporous calcium phosphates, the favourable osteoinductive properties by virtue of the surface-microporosity can be retained for prolonged shelf life.Type: ApplicationFiled: July 23, 2010Publication date: January 26, 2012Inventors: Joost Dick DE BRUIJN, Huipin Yuan, Florence De Groot, Noel Davison, Davide Barbieri
-
Patent number: 8071083Abstract: The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold to be vascularized until a substantially sufficient fluid flow through said scaffold is assured for the transport of nutrients and/or waste products, and seeding said vascularised scaffold with a suitable population of tissue-regenerating cells.Type: GrantFiled: December 8, 2005Date of Patent: December 6, 2011Assignee: Progentix Orthobiology B.V.Inventors: Joost Dick De Bruijn, Gerrit Jacobus Meijer
-
Publication number: 20110293584Abstract: The present invention relates to a method of treating a tissue defect in a human or animal body comprising the steps of implanting into said body an unseeded scaffold; allowing or effecting a wound healing response at the site of said defect; allowing said scaffold to be vascularized until a substantially sufficient fluid flow through said scaffold is assured for the transport of nutrients and/or waste products, and seeding said vascularised scaffold with a suitable population of tissue-regenerating cells.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Applicant: PROGENTIX B.V.Inventors: Joost Dick DE BRUIJN, G. J. MEIJER
-
Patent number: 7942934Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: GrantFiled: October 28, 2009Date of Patent: May 17, 2011Assignee: Progentix Orthobiology B.V.Inventors: Huipin Yuan, Joost Dick De Bruijn
-
Publication number: 20110111004Abstract: The present invention relates porous osteoinductive nanocomposites and for the methods to prepare osteoinductive nanocomposites. The osteoinductive composites consist of biocompatible polymers and non-heated (or non-sintered), needle-shaped or plate-like calcium phosphate nanocrystals and the methods comprise the steps of: a. adding phosphate to a calcium solution thereby evoking precipitation of calcium phosphate nanocrystals; b. washing the nanocrystals with water and suspending them in an organic solvent or getting dry calcium phosphate nanocrystals after evaporating organic solvent; c.Type: ApplicationFiled: May 27, 2009Publication date: May 12, 2011Inventors: Davide Barbieri, Huipin Yuan, Joost Dick De Bruijn
-
Publication number: 20110020419Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: ApplicationFiled: February 19, 2007Publication date: January 27, 2011Inventors: Huipin Yuan, Joost Dick De Bruijn
-
Publication number: 20100034865Abstract: The invention relates to a porous osteoinductive calcium phosphate material having an average grain size in a range of 0.1-1.50 ?m, having a porosity consisting essentially only of micropores in a size range of 0.1-1.50 ?m, and having a surface area percentage of micropores in a range of 10-40%.Type: ApplicationFiled: October 28, 2009Publication date: February 11, 2010Inventors: Huipin YUAN, Joost Dick De Bruijn
-
Patent number: 6838284Abstract: The invention relates to a culture medium for culturing cells, in particular human cells in a process for tissue engineering bone. The medium comprises glucose, a mineral, a vitamin, a growth factor and L-glutamine, wherein the L-glutamine is present in a concentration of at least 300 mg/L.Type: GrantFiled: June 21, 2002Date of Patent: January 4, 2005Assignee: IsoTis N.V.Inventors: Joost Dick de Bruijn, Gerhardus Johannes M. Tibbe, Sandra Claudia da Silva Madureira Mendes