Abstract: The present invention relates to various methods of treatment using a novel blood perfusion device.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: A bioreactor is provided which contains cells capable of producing cytokine inhibitors in response to cytokines, in a manner regulated by the local or systemic milieu of an individual patient and predicted by mechanistic computational simulations. The bioreactor transfers the cytokine inhibitors to a patient in need of control of the inflammation process as part of a disease or condition in the patient, such as sepsis, trauma, traumatic brain injury, or wound healing. Related methods also are provided.

Abstract: The invention relates to a method of measuring the biaxial shaping behaviour of metal materials, more particularly sheet metal. In the measuring method a flow locus curve comprehensively describing the shaping behaviour of the material is determined by determining the flow limits under tensile and compressive loading of secondary samples of a primary sample previously subjected to at least tensile, but preferably also to compressive loading. Preferably a number of flow locus curves of different preliminary loading of the primary sample are determined for each material. These flow locus curves, completely ascertained by tests, provide the further processor with a reliable ancillary means of selecting a material required for the particular shaping operation.

Abstract: This invention relates to a module (1) for culturing and using metabolisms for maintaining microorganisms (9), particularly for cells or bacteria, comprising an outer casing (2), at least three independent membrane systems, whereof at least two are constructed as hollow fiber membranes (3) and are located in the inner space (4) of the module (1), and that the hollow fiber membranes (3) form a close packed, space network (5) and microorganisms (9) are located in the cavities of the network (5) and/or adhere to the hollow fiber membranes (3).