Abstract: Systems and methods for use of the imaging system are presented. In an embodiment, the imaging system includes a first optical path, a second optical path, a plurality of optical elements, a detector, and a processor. The first optical path guides a first beam of radiation associated with epiluminescence while the second optical path guides a second beam of radiation associated with optical coherence tomography. The plurality of optical elements transmit the first and second beams of radiation onto a sample. The detector generates optical data associated with the first and second beams of radiation returning from the sample. The optical data associated with the first and second beams of radiation correspond to substantially non-coplanar regions of the sample. The processor correlates the optical data of the first beam with the optical data of the second beam and generates an image of the sample.

Abstract: Systems and methods are presented for modulating a beam of radiation, such that the modulated beam exhibits substantially null residual amplitude modulation (RAM). An electro-optical modulator is presented that includes a waveguide, a first region associated with the waveguide and a second region associated with the waveguide. The waveguide is designed to guide a beam of radiation. A first electric potential applied to the first region causes a first modulation to the beam of radiation while a second electric potential applied to the second region causes a second modulation to the beam of radiation. The first modulation combined with the second modulation provides substantially null residual amplitude modulation of the beam of radiation.

Abstract: A system for chromatic dispersion compensation is presented. The system includes an optical splitting element, a plurality of optical elements, and a plurality of waveguides. The optical splitting element is configured to generate at least a first beam of radiation and a second beam of radiation. The plurality of optical elements is configured to identify one or more optical paths amongst a plurality of optical paths for the first beam of radiation to travel. One of the plurality of waveguides disposed in one of the plurality of optical paths has group delay and dispersion coefficient properties per unit length that are different from group delay and dispersion coefficient properties per unit length of another one of the plurality of waveguides disposed in another one of the plurality of optical paths. The group delay and dispersion coefficient properties per unit length compensate for a chromatic dispersion associated with the second beam of radiation.

Abstract: The present invention relates to an electronic gastrointestinal capsule protected by an outer biocompatible shell resistant to the environment in the digestive system comprising a light source (4); splitting means (5) to split the light beam, directing it to the reference arm (6) and the sampling arm (9); an adjustable group delay element (24) depending on the distance to the tissue to analyse; optical moving means moving the intersection of the light beam (30) of the sampling arm (9) across the tissue; an optical system (8) focusing the light beam (30) from the sampling arm (9) on the tissue; interference means (10) producing interference between the reflected light; a detector (11) receiving said interference; processing means (2) processing the information acquired by the detector (11); and power supply means (3) supplying power to the capsule without a physical connection to the outside.

Abstract: A system includes a waveguide that guides a beam of radiation, a variable delay unit, and a polarization-dependent modulating unit. The variable delay unit modulates the refractive index in a region, and the waveguide makes a plurality of passes through the region. The polarization-dependent element compensates for birefringence associated with the beam of radiation and includes a polarization splitter and a plurality of modulating elements. The polarization splitter has a first arm and a second arm that each include modulation segments. The beam of radiation is split between the first arm and the second arm and recombined after traversing the modulation segments. The recombination of the beam generates a first polarized beam of radiation and a second polarized beam of radiation. The plurality of modulating elements apply a first and second modulation to the first polarized beam of radiation and the second polarized beam of radiation respectively.

Abstract: A system for lateral scanning of a sample using optical coherence tomography is presented. The low coherence interferometry system includes a first multiplexing unit and a second multiplexing unit. The first multiplexing unit is configured to receive a first beam of radiation and includes a first plurality of optical delay elements configured to introduce a group delay to the first beam of radiation based on an optical path traversed by the first beam of radiation among a first plurality of optical waveguides. The second multiplexing unit is configured to receive a second beam of radiation. The second multiplexing unit includes a second plurality of optical modulating elements configured to differentiate the second beam of radiation among a second plurality of optical waveguides to produce one or more output radiation beams. The second plurality of optical waveguides is configured to guide the one or more output radiation beams towards a sample.