Abstract: Methods and systems for online sampling an aliquot from a mobile phase comprising an analyte for producing a pharmaceutical or chemical product, wherein the apparatus comprises an analytical device and a tube between an inlet and an outlet, wherein the outlet is in fluid communication with the analytical device, the method comprising: providing a sample device comprising a needle with a needle tip, a septum pierceable by the needle and a pump, wherein the needle is moveable between an extended position in which the septum is pierced by the needle, and a retracted position, in which the septum is not pierced, disposing the sample device at the curved portion of the tube, moving the needle to the extended position such that the needle tip faces the flow direction, and drawing out an aliquot out of the mobile phase.

Abstract: A method for online sampling an aliquot from a mobile phase comprising an analyte of an apparatus (102) for producing a pharmaceutical or chemical product, wherein the apparatus (102) comprises an analytical device (114) and a tube (112), wherein the tube (112) comprises an inlet (116), an outlet (118) and at least one curved portion (120), wherein the outlet (118) is in fluid communication with the analytical device (114), wherein the curved portion (120) is located between the inlet (116) and the outlet (118), wherein a flow direction of the mobile phase is defined from the inlet (116) to the outlet (118), the method comprising: providing a sample device (124) comprising a needle (134) with a needle tip (136), a septum (138) pierceable by the needle (134) and a pump (128), wherein the needle (134) is moveable between an extended position in which the septum (138) is pierced by the needle (134), and a retracted position, in which the septum (138) is not pierced, disposing the sample device (124) at the curve