Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems and techniques are provided for enabling all wins multiplier features on gaming devices during multiplayer gaming tournament play. The all wins multiplier features may be simultaneously engaged on multiple gaming devices at a predetermined point in time, and may generally all simultaneously terminate the all wins multiplier feature at the same time. Multiple different all wins multiplier features using different multiplier values may be enabled at different times during a particular tournament session.

Abstract: An electronic gaming system is described. The electronic gaming system includes a server computing device configured to receive an input from a first user computing device including a request to initiate an electronic game and assign a plurality of user devices to the electronic game. The server is further configured to identify a second player account as an initial play player account, wherein the initial play player account is designated to initiate a first play of the electronic game. The server is further configured to transmit content to a second user computing device that causes a gameplay user interface at the second user computing device to include a first display area including video images from a video stream from the second user computing device and a second display area including video images received by the server from a video stream received from the first user computing device.

Abstract: Aspects of subject technology provide systems and methods for generation and distribution of a stable identifier associated with multiple aliases of a user account. The stable identifier may be provided to various electronic devices by a server, responsive to requests associated with communications to those devices from one of the associated aliases. In this way, messaging applications can utilize the stable identifier to merge conversations from a single user having multiple aliases, and secure access to a secure device can be provided to an authorized user, even if the authorized user attempts access from an unauthorized account alias.

Abstract: A method and apparatus (3) for operating a rotary milking platform (1) to maximise the number of animals milked per unit time. The milking platform (1) is rotated about a central vertical axis (4) by a variable speed motor (6), and comprises a plurality of animal accommodating locations (5) for the animals being milked. An entry position (7) and an exit position (9) accommodate animals to and from the platform (1). A position sensor (10) monitors the angular position of the platform (1). An RFID sensor (12) reads the identity of animals entering the platform (1). Historical data relating to milking time per milking session and the milk yield per animal per session is stored in an electronic memory (17). A microprocessor (15) reads signals from flow meters (14) which monitor the milk flow from milking clusters of each animal accommodating location (5).

Abstract: A method and apparatus (3) for operating a rotary milking platform (1) to maximise the number of animals milked per unit time. The milking platform (1) is rotated about a central vertical axis (4) by a variable speed motor (6), and comprises a plurality of animal accommodating locations (5) for the animals being milked. An entry position (7) and an exit position (9) accommodate animals to and from the platform (1). A position sensor (10) monitors the angular position of the platform (1). An RFID sensor (12) reads the identity of animals entering the platform (1). Historical data relating to milking time per milking session and the milk yield per animal per session is stored in an electronic memory (17). A microprocessor (15) reads signals from flow meters (14) which monitor the milk flow from milking clusters of each animal accommodating location (5).

Abstract: The disclosure provides nucleic acidvectors containing a high expression promoter, such as a high expression, supporting cell-specific promoter, operably linked to a polynucleotide encoding Atoh1. Such vectors and compositions containing the same can be used to induce robust regeneration of mature hair cells (e.g., cochlear and/or vestibular hair cell regeneration). Accordingly, the nucleic acid vectors and compositions described herein can be used to treat subjects having or at risk of developing hearing loss or vestibular dysfunction.

Abstract: An impeller for a pump for a dishwasher having a base with an axis of rotation, and at least one fin protruding from the base. The impeller also has a cap removably coupled to the impeller and at least one blade integrally formed with the cap.

Abstract: The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with mutations in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.

Abstract: Systems and methods are provided for managing the order of data written to a transaction log in a distributed storage system. In a system with multiple nodes, if sequencers are naively generated without taking into consideration inconsistencies among the different nodes generating the sequencers, then the sequencers may not increase for each data transaction. To alleviate this problem, the node committing the transaction to the transaction log may perform a consistent read and verifies that the sequencer advances. If the sequencer does not advance, the node can perform a context-dependent operation such as adjusting the sequencer, acknowledging the write without committing it to the transaction log, or rejecting the write altogether.

Abstract: The disclosure provides Sox2 inhibitors that can be used to generate Type I vestibular hair cells in the vestibular system. The Sox2 inhibitors may be administered to a subject alone or in combination with a regeneration agent to convert Type II vestibular hair cells or regenerated vestibular hair cells to Type I vestibular hair cells.

Abstract: Techniques for server control of client authorization proof of possession are described herein. In various embodiments, a first server provisions client authorization proof of possession for a client device a real-world time, a client public key, and a client private key. The first server generates provisioning response message(s) including the client public key, the client private key, the real-world time, and/or an assertion object, and sends the message(s) to the client device. In various embodiments, a client device obtains an authorization proof token generated based on a client public key, a client private key, and a real-world time provisioned by a first server. The client device generates a request and sends the request to a second server, the request includes the authorization proof token and an assertion object from the first server signed by a server private key and an expiration time and a reference to the client public key.

Abstract: Techniques for server control of client authorization proof of possession are described herein. In various embodiments, a first server provisions client authorization proof of possession for a client device a real-world time, a client public key, and a client private key. The first server generates provisioning response message(s) including the client public key, the client private key, the real-world time, and/or an assertion object, and sends the message(s) to the client device. In various embodiments, a client device obtains an authorization proof token generated based on a client public key, a client private key, and a real-world time provisioned by a first server. The client device generates a request and sends the request to a second server, the request includes the authorization proof token and an assertion object from the first server signed by a server private key and an expiration time and a reference to the client public key.

Abstract: A personal protection equipment (PPE) gown formed by one piece woven (OPW) techniques. The gown features an outer coating on the fabric to provide required liquid penetration resistance.

Abstract: The disclosure provides polynucleotides containing inner hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in inner hair cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote inner hair cell-specific expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing hearing loss.

Abstract: The disclosure provides polynucleotides containing SLC6A14 promoters, as well as vectors containing the same, that can be used to promote expression of a transgene in vestibular supporting cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote vestibular supporting cell expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing vestibular dysfunction.

Abstract: An impeller for a pump for a dishwasher having a base with an axis of rotation, and at least one fin protruding from the base. The impeller also has a cap removably coupled to the impeller and at least one blade integrally formed with the cap.

Abstract: The disclosure provides polynucleotides containing outer hair cell-specific promoters, as well as vectors containing the same, that can be used to promote expression of a transgene specifically in outer hair cells. The polynucleotides described herein may be operably linked to a transgene, such as a transgene encoding a therapeutic protein, so as to promote outer hair cell-specific expression of the transgene. The polynucleotides described herein may be operably linked to a therapeutic transgene and used for the treatment of subjects having or at risk of developing hearing loss.

Abstract: A rotary milking platform (3) comprises a plurality of stalls (5) and an RFID animal identifying system (9) for identifying animals entering the stalls (5) of the platform (3). A microprocessor (14) reads signals from an image capturing device (15) and computes a feature vector from the captured image of each animal. A plurality of reference feature vectors comprising respective matrices of metrics already derived from images of the respective animals captured by the image capturing device (15) are stored and cross-referenced with the identity of the respective animals. The microprocessor (14) compares computed feature vectors of each animal with the stored reference feature vectors until a best match has been determined with one of the reference feature vectors. The identity of the animal of that matching reference feature vector is then determined as the identity of the animal of that computed feature vector.

Abstract: The disclosure features compositions and methods for the treatment of sensorineural hearing loss and auditory neuropathy, particularly forms of the disease that are associated with a mutation in otoferlin (OTOF), by way of OTOF gene therapy. The disclosure provides a variety of compositions that include a first nucleic acid vector that contains a polynucleotide encoding an N-terminal portion of an OTOF isoform 5 protein and a second nucleic acid vector that contains a polynucleotide encoding a C-terminal portion of an OTOF isoform 5 protein. These vectors can be used to increase the expression of OTOF in a subject, such as a human subject suffering from sensorineural hearing loss.