Patents by Inventor Joseph J. Mitala

Joseph J. Mitala has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220011302
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a bio-molecule that preferentially binds to a particular analyte.
    Type: Application
    Filed: September 13, 2021
    Publication date: January 13, 2022
    Inventors: Alan T. Johnson, JR., Ye Lu, Joseph J. Mitala, JR., Bohdana Discher, Brett R. Goldsmith
  • Patent number: 11119097
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: September 14, 2021
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Ye Lu, Joseph J. Mitala, Bohdana Discher, Brett R. Goldsmith
  • Patent number: 10900971
    Abstract: The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 26, 2021
    Assignees: The Trustees of the University of Pennsylvania, The Board of Trustees of the University of Illinois
    Inventors: Alan T. Johnson, Jr., Brett R. Goldsmith, Joseph J. Mitala, Jr., Bohdana M. Discher, Stephen G. Sligar, Timothy H. Bayburt
  • Publication number: 20170299602
    Abstract: The present invention provides biomimetic sensor devices that utilize proteins—such G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
    Type: Application
    Filed: November 16, 2016
    Publication date: October 19, 2017
    Inventors: Alan T Johnson, Jr., Brett R Goldsmith, Joseph J Mitala, Jr., Bohdana Discher, Stephen G Sligar, Timothy H Bayburt
  • Patent number: 9612240
    Abstract: The present invention provides biomimetic sensor devices that utilize proteins—such as G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: April 4, 2017
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Alan T. Johnson, Jr., Brett R. Goldsmith, Joseph J. Mitala, Jr., Bohdana Discher, Stephen G. Sligar, Timothy H. Bayburt
  • Publication number: 20150065363
    Abstract: The present invention provides biomimetic sensor devices that utilize proteins—such as G-protein coupled receptors—and are useful in high-sensitivity analysis of analyte-containing samples. These sensors may be used to determine the presence or concentration of one or more analytes in a sample. The invention also includes methods of fabricating the devices and methods of using the devices to assay samples.
    Type: Application
    Filed: June 29, 2011
    Publication date: March 5, 2015
    Applicant: the Trustees of The University of Pennsylvania
    Inventors: Alan T. Johnson, JR., Brett R. Goldsmith, Joseph J. Mitala, JR., Bohdana Discher, Stephen G. Sligar, Timothy H. Bayburt
  • Publication number: 20140308682
    Abstract: Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.
    Type: Application
    Filed: November 20, 2012
    Publication date: October 16, 2014
    Applicant: The Trustees of The University of Pennsylvania
    Inventors: Alan T. Johnson, JR., Ye Lu, Joseph J. Mitala, Bohdana Discher