Patents by Inventor Joseph K. Wichmann

Joseph K. Wichmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trihydroxyvitamin D.sub.3 compounds
    Patent number: 4360472
    Abstract: A novel side chain trihydroxylated vitamin D.sub.3 compound, namely 23,24,25-trihydroxyvitamin D.sub.3 and its acylated and alkylsilyated derivatives are provided. The new compounds are hydroxy analogs of the biologically-active 25-hydroxyvitamin D.sub.3 and would find application as substitutes for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: November 23, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann
  • 23-Dehydro-25-hydroxyvitamin D.sub.3
    Patent number: 4360471
    Abstract: A novel vitamin D.sub.3 compound, 23-dehydro-25-hydroxyvitamin D.sub.3, and hydroxy-protected derivatives thereof are provided. The new compound is a side-chain-desaturated analog of 25-hydroxycholecalciferol, and would find application as a substitute for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: December 11, 1981
    Date of Patent: November 23, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann
  • Process for preparing vitamin D-lactones
    Patent number: 4336193
    Abstract: The invention provides methods for preparing the various isomeric forms of 25-hydroxyvitamin D.sub.3 -26,23-lactone utilizing cyanohydrin formation with readily prepared steroid materials followed by actinic radiation of the products and recovery of the desired 25-hydroxyvitamin D.sub.3 -26,23-lactone.The invention also provides new intermediate compounds in their various isomeric forms derived during the process for preparing the said vitamin D.sub.3 lactones.25-Hydroxyvitamin D.sub.3 -26,23-lactone is recognized as having vitamin D-like activity and is believed to play an important role in the regulation of calcium and phosphate levels in the animal and human organism. The present invention provides a convenient method for preparing the various isomeric forms of this compound.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: June 22, 1982
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Herbert E. Paaren, Joseph K. Wichmann, Mary A. Fivizzani
  • Vitamin D-lactone derivative and process for preparing same
    Patent number: 4307231
    Abstract: The invention provides a new vitamin D compound, 1.alpha.,25-dihydroxy-vitamin D.sub.3 26,23-lactone.The compound is characterized by vitamin D-like activity.
    Type: Grant
    Filed: July 18, 1980
    Date of Patent: December 22, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Herbert E. Paaren, Joseph K. Wichmann
  • 23,25-Dihydroxyvitamin D.sub.3
    Patent number: 4279826
    Abstract: 23,25-Dihydroxyvitamin D.sub.3 a new derivative of vitamin D.sub.3. The compound is the 23-hydroxylated analog of biologically potent 23-hydroxycholecalciferol and by virtue of such structural similarity should find application as a substitute for such compound or for vitamin D.sub.3.
    Type: Grant
    Filed: September 22, 1980
    Date of Patent: July 21, 1981
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Yoko Tanaka, Joseph K. Wichmann
  • 25-Hydroxycholecalciferol-26,23-lactone
    Patent number: 4223131
    Abstract: The invention provides a new derivative of vitamin D, 25-hydroxycholecalciferol-26,23-lactone.The compound is characterized by vitamin D-like activity in its ability to increase serum calcium concentration by mobilizing bone and would find application in disease states requiring the elevation of serum calcium concentration.
    Type: Grant
    Filed: January 26, 1979
    Date of Patent: September 16, 1980
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Heinrich K. Schnoes, Joseph K. Wichmann