Patents by Inventor Joseph L. Kuijper

Joseph L. Kuijper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20240002466
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: March 10, 2023
    Publication date: January 4, 2024
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • CD112 variant immunomodulatory proteins and uses thereof
    Patent number: 11834490
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD112 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: December 5, 2023
    Assignee: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan Swanson, Michael Kornacker, Daniel William Demonte, Mark F. Maurer, Dan Ardourel, Joseph L. Kuijper
  • CTLA-4 variant immunomodulatory proteins and uses thereof
    Patent number: 11753458
    Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: September 12, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Lawrence Evans, Joseph L. Kuijper, Ryan Swanson
  • PD-L2 variant immunomodulatory proteins and uses thereof
    Patent number: 11732022
    Abstract: Provided herein are immunomodulatory proteins comprising variant PD-L2 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: August 22, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Dan Ardourel, Daniel William Demonte, Joseph L. Kuijper
  • CTLA-4 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20230250152
    Abstract: Provided herein are variant CTLA-4 polypeptides and immunomodulatory proteins and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of disease applications, including for treatment of autoimmune or inflammatory conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 30, 2023
    Publication date: August 10, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Lawrence EVANS, Joseph L. Kuijper, Ryan Swanson
  • APRIL AND BAFF INHIBITORY IMMUNOMODULATORY PROTEINS WITH AND WITHOUT A T CELL INHIBITORY PROTEIN AND METHODS OF USE THEREOF
    Publication number: 20230241168
    Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers) alone, or also coupled with inhibition of T cell costimulation. The immunomodulatory proteins provided herein include variant domains of B cell maturation antigen (BCMA) alone, or multi-domain immunomodulatory protein that inhibit B cell responses and also can inhibit T cell costimulation. Also provided are nucleic acids molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases or conditions. Also provided are compositions and methods for making and using such proteins.
    Type: Application
    Filed: May 7, 2021
    Publication date: August 3, 2023
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Stacey DILLON, Mark RIXON, Lawrence EVANS, Daniel William DEMONTE, Joseph L. KUIJPER, Stanford L. PENG, Ryan SWANSON
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11639375
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: May 2, 2023
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD86 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20220372106
    Abstract: Provided herein are variant CD86 polypeptides, immunomodulatory proteins comprising variant CD86 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: November 27, 2019
    Publication date: November 24, 2022
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Dan ARDOUREL, Steven Dennis LEVIN, Joseph L. KUIJPER
  • APRIL and BAFF inhibitory immunomodulatory proteins and methods of use thereof
    Patent number: 11274140
    Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: March 15, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Stacey Dillon, Mark Rixon, Lawrence Evans, Daniel William Demonte, Joseph L. Kuijper, Stanford L. Peng
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11230588
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: January 25, 2022
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • APRIL AND BAFF INHIBITORY IMMUNOMODULATORY PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20210388054
    Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.
    Type: Application
    Filed: May 7, 2021
    Publication date: December 16, 2021
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Stacey DILLON, Mark RIXON, Lawrence EVANS, Daniel William DEMONTE, Joseph L. KUIJPER, Stanford L. PENG
  • APRIL AND BAFF INHIBITORY IMMUNOMODULATORY PROTEINS AND METHODS OF USE THEREOF
    Publication number: 20210363223
    Abstract: Provided herein are immunomodulatory proteins that exhibit neutralizing activity of BAFF and APRIL (or BAFF/APRIL heterotrimers). The immunomodulatory proteins provided herein include variant domains of Transmembrane Activator and CAML Interactor (TACI). Among provided immunodulatory proteins are TACI-Fc fusion proteins. Also provided are nucleic acid molecules encoding the immunomodulatory proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological diseases, disorders or conditions. Also provided are compositions and methods for making and using such proteins.
    Type: Application
    Filed: June 11, 2021
    Publication date: November 25, 2021
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Stacey DILLON, Mark RIXON, Lawrence EVANS, Daniel William DEMONTE, Joseph L. KUIJPER, Stanford L. PENG
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117948
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117950
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11117949
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 29, 2021
    Date of Patent: September 14, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD80 variant immunomodulatory proteins and uses thereof
    Patent number: 11096988
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 24, 2021
    Assignee: Alpine Immune Sciences, Inc.
    Inventors: Ryan Swanson, Michael Kornacker, Mark F. Maurer, Joseph L. Kuijper
  • CD112 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20210253668
    Abstract: Provided herein are immunomodulatory proteins comprising variant CD112 and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: July 27, 2017
    Publication date: August 19, 2021
    Applicant: ALPINE IMMUNE SCIENCES, INC.
    Inventors: Ryan SWANSON, Michael KORNACKER, Daniel William DEMONTE, Mark F. MAURER, Dan ARDOUREL, Joseph L. KUIJPER
  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20210188942
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 29, 2021
    Publication date: June 24, 2021
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER, Mark F. MAURER, Dan ARDOUREL, Daniel William DEMONTE, Joseph L. KUIJPER
  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20210171603
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 29, 2021
    Publication date: June 10, 2021
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER, Mark F. MAURER, Dan ARDOUREL, Daniel William DEMONTE, Joseph L. KUIJPER
  • CD80 VARIANT IMMUNOMODULATORY PROTEINS AND USES THEREOF
    Publication number: 20210163571
    Abstract: Provided herein are variant CD80 polypeptides, immunomodulatory proteins comprising variant CD80 polypeptides, and nucleic acids encoding such proteins. The immunomodulatory proteins provide therapeutic utility for a variety of immunological and oncological conditions. Compositions and methods for making and using such proteins are provided.
    Type: Application
    Filed: January 28, 2021
    Publication date: June 3, 2021
    Applicant: Alpine Immune Sciences, Inc.
    Inventors: Ryan SWANSON, Michael KORNACKER, Mark F. MAURER, Dan ARDOUREL, Daniel William DEMONTE, Joseph L. KUIJPER