Patents by Inventor Joseph M. DeSimone

Joseph M. DeSimone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10792857
    Abstract: The invention generally relates to microneedle devices, methods of making same, pharmaceutical compositions comprising same, and methods of treating a disease comprising administering same. Specifically, the disclosed microneedle devices comprise a plurality of biocompatible microneedles having one or more of: (i) a curved, discontinuous, undercut, and/or perforated sidewall; (ii) a sidewall comprising a breakable support; and (iii) a cross-section that is non-circular and non-polygonal. The microneedles may also be tiered. Alternatively, the microneedles may be tiered. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: March 12, 2016
    Date of Patent: October 6, 2020
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Joseph M. Desimone, Gregory R. Robbins, Ashley R. Johnson
  • Publication number: 20200231841
    Abstract: A method of forming a three-dimensional object, wherein said three-dimensional object is a footwear sole, heel, innersole or midsole, is described. The method may use a polymerizable liquid, or resin, useful for the production by additive manufacturing of a three-dimensional object, comprising a mixture of (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from said first component.
    Type: Application
    Filed: February 27, 2020
    Publication date: July 23, 2020
    Inventors: Jason P. Rolland, Kai Chen, Justin Poelma, James Goodrich, Robert K. Pinschmidt, JR., Joseph M. DeSimone, Lloyd M. Robeson
  • Patent number: 10710305
    Abstract: The present invention relates to methods and an apparatus for the fabrication of solid three-dimensional objects from liquid polymerizable materials.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: July 14, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Alexander Ermoshkin, Edward T. Samulski
  • Publication number: 20200190357
    Abstract: A method of forming a three-dimensional object (e.g. comprised of polyurethane, polyurea, or copolymer thereof) is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid comprising a mixture of: (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the second solidifiable component; and then (d) contacting the three-dimensional intermediate to water to form the three-dimensional object.
    Type: Application
    Filed: February 27, 2020
    Publication date: June 18, 2020
    Inventors: Jason P. Rolland, Kai Chen, Justin Poelma, James Goodrich, Robert Pinschmidt, Joseph M. DeSimone, Lloyd M. Robeson
  • Patent number: 10668709
    Abstract: A method of forming a three-dimensional object (17) includes: providing a carrier (18) and an optically transparent member (15) having a build surface, the carrier (18) and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid (16); irradiating the build region with light (12) through the optically transparent member (15) to form a solid polymer from the polymerizable liquid; and advancing the carrier (18) away from the build surface to form the three-dimensional object (17) from the solid polymer. The carrier (18) includes at least one retain and release (34) feature that is configured to: i) retain the three-dimensional object (17) formed from the solid polymer on the carrier (18) in a first state; and ii) facilitate release of the three-dimensional object (17) formed from the solid polymer from the carrier (18) in a second state.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: June 2, 2020
    Assignee: Carbon, Inc.
    Inventors: Alexander Ermoshkin, David Shirvanyants, Joseph M. DeSimone, Nordstrom Kirk Phelps, Jason P. Rolland
  • Patent number: 10661501
    Abstract: A method of forming a three-dimensional object includes: providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid, irradiating the build region with light through the optically transparent member to form a solid polymer from the polymerizable liquid, and advancing said carrier away from said build surface to form said three-dimensional object from said solid polymer. The irradiating step includes projecting focused light at the build region, and the advancing step is carried out at a rate that is dependent on an average light intensity of the focused light. An apparatus to perform the method is also disclosed.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: May 26, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Nordstrom Kirk Phelps, Alexander Ermoshkin
  • Patent number: 10647880
    Abstract: A method of forming a three-dimensional object of polyurethane, polyurea, or copolymer thereof is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including at least one of: (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the chain extender; and then (d) heating or microwave irradiating the three-dimensional intermediate sufficiently to form from the three-dime
    Type: Grant
    Filed: February 7, 2019
    Date of Patent: May 12, 2020
    Assignee: Carbon, Inc.
    Inventors: Jason P. Rolland, Kai Chen, Justin Poelma, James Goodrich, Robert Pinschmidt, Joseph M. DeSimone, Lloyd M. Robeson
  • Patent number: 10647879
    Abstract: A polymerizable liquid, or resin, useful for the production by additive manufacturing of a three-dimensional object of polyurethane, polyurea, or a copolymer thereof, is described. The resin includes at least one of (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: May 12, 2020
    Assignee: Carbon, Inc.
    Inventors: Jason P. Rolland, Kai Chen, Justin Poelma, James Goodrich, Robert Pinschmidt, Joseph M. DeSimone, Lloyd M. Robeson
  • Publication number: 20200139617
    Abstract: A method of forming a three-dimensional object, comprises providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a polymerizable liquid; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid while concurrently advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof, the gradient of polymerization zone comprising the polymerizable liquid in partially cured form. Apparatus for carrying out the method is also described.
    Type: Application
    Filed: November 29, 2018
    Publication date: May 7, 2020
    Inventors: Joseph M. DeSimone, Alexander Ermoshkin, Nikita Ermoshkin, Edward T. Samulski
  • Publication number: 20200130266
    Abstract: An integrated additive manufacturing system includes: (a) at least one resin supply (41); (b) a plurality of additive manufacturing machines (43) on which parts may be produced, each of the additive manufacturing machines (43) operatively associated with the at least one resin supply (41); and (c) at least one peripheral machine (200, 48, 220) operatively associated with each of the additive manufacturing machines and the at least one resin supply.
    Type: Application
    Filed: March 12, 2018
    Publication date: April 30, 2020
    Inventors: Joseph M. DeSimone, Roy Goldman, Steven Kenneth Pollack
  • Patent number: 10618215
    Abstract: A method of forming a three-dimensional object, is carried out by (a) providing a carrier and a build plate, the build plate comprising a semipermeable member, the semipermeable member comprising a build surface with the build surface and the carrier defining a build region therebetween, and with the build surface in fluid communication by way of the semipermeable member with a source of polymerization inhibitor; (b) filling the build region with a polymerizable liquid, the polymerizable liquid contacting the build surface; (c) irradiating the build region through the build plate to produce a solid polymerized region in the build region, while forming or maintaining a liquid film release layer comprised of the polymerizable liquid formed between the solid polymerized region and the build surface, the polymerization of which liquid film is inhibited by the polymerization inhibitor; and (d) advancing the carrier with the polymerized region adhered thereto away from the build surface on the build plate to create
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: April 14, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Alexander Ermoshkin, Nikita Ermoshkin, Edward T. Samulski
  • Publication number: 20200094470
    Abstract: A method of forming a three-dimensional object by bottom-up three-dimensional fabrication by irradiating a polymerizable liquid to produce the three-dimensional object, is described. In the method: (i) a Lewis acid or an oxidizable tin salt (e.g., stannous octoate) is included in said polymerizable liquid in an amount effective to accelerate the formation of said three-dimensional object during said fabrication; and/or (ii) the three-dimensional object is irradiated after forming to further polymerize unpolymerized material remaining in the three-dimensional object.
    Type: Application
    Filed: November 26, 2019
    Publication date: March 26, 2020
    Inventors: Jason P. Rolland, Joseph M. DeSimone
  • Patent number: 10596755
    Abstract: A method of forming a three-dimensional object, is carried out by (a) providing a carrier and a build plate, the build plate comprising a semipermeable member, the semipermeable member comprising a build surface with the build surface and the carrier defining a build region therebetween, and with the build surface in fluid communication by way of the semipermeable member with a source of polymerization inhibitor; (b) filling the build region with a polymerizable liquid, the polymerizable liquid contacting the build surface, (c) irradiating the build region through the build plate to produce a solid polymerized region in the build region, while forming or maintaining a liquid film release layer comprised of the polymerizable liquid formed between the solid polymerized region and the build surface, wherein the polymerization of which liquid film is inhibited by the polymerization inhibitor; and (d) advancing the carrier with the polymerized region adhered thereto away from the build surface on the build plate t
    Type: Grant
    Filed: August 20, 2018
    Date of Patent: March 24, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Alexander Ermoshkin, Edward T. Samulski
  • Patent number: 10589512
    Abstract: Methods and apparatus for additive manufacturing of three-dimensional objects from polymerizable liquids are described. The methods and apparatus are implemented in the form of a bottom up additive manufacturing apparatus, and in preferred embodiments are implemented in the form of Continuous Liquid Interface Production (or “CLIP”) methods and apparatus. Rotation of at least one of the carrier and the build plate is preferably included, for example to facilitate the filling of the build region with the polymerizable liquid.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: March 17, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Edward T. Samulski, Jason P. Rolland
  • Publication number: 20200078301
    Abstract: The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
    Type: Application
    Filed: November 20, 2019
    Publication date: March 12, 2020
    Inventors: JOSEPH M. DESIMONE, Jason P. Rolland, Benjamin W. Maynor, Larken E. Euliss, Ginger Denison Rothrock, Ansley E. Dennis, Edward T. Samulski, R. Jude Samulski
  • Patent number: 10569465
    Abstract: A method of forming a three-dimensional object includes: providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween, filling the build region with a polymerizable liquid, irradiating the build region with light through the optically transparent member to form a solid polymer from the polymerizable liquid, and advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer. The irradiating step is carried out with a plurality of tiled images projected into the build region, and each tiled image includes an array of projected pixels. An apparatus to perform the method is also discloses.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: February 25, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Nordstrom Kirk Phelps, Alexander Ermoshkin
  • Patent number: 10538030
    Abstract: A method of forming a three-dimensional object useful as a casting mold is carried out by providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; filling the build region with a liquid photocurable ceramic resin; irradiating the build region through the optically transparent member to form a solid polymer from the polymerizable liquid and advancing the carrier away from the build surface to form the three-dimensional object from the solid polymer, while also concurrently with the irradiating and/or advancing steps: (i) continuously maintaining a dead zone of polymerizable liquid in contact with the build surface, and (ii) continuously maintaining a gradient of polymerization zone between the dead zone and the solid polymer and in contact with each thereof. The gradient of polymerization zone comprises the polymerizable liquid in partially cured form (e.g.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: January 21, 2020
    Assignee: Carbon, Inc.
    Inventors: Joseph M. DeSimone, Edward T. Samulski, Alexander Ermoshkin, Philip M. DeSimone
  • Publication number: 20200009852
    Abstract: Described herein are methods, systems and apparatus (including associated control methods, systems and apparatus), for the production of a three-dimensional object by “bottom up” additive manufacturing, in which a carrier is vertically reciprocated with respect to a build surface, to enhance or speed the refilling of the build region with a solidifiable liquid. In preferred (but not necessarily limiting) embodiments, the three-dimensional object is produced from a liquid interface by continuous liquid interface production (i.e., “CLIP”).
    Type: Application
    Filed: September 16, 2019
    Publication date: January 9, 2020
    Inventors: Alexander Ermoshkin, David Shirvanyants, Nordstrom Kirk Phelps, Nikita Ermoshkin, Edward T. Samulski, Joseph M. DeSimone
  • Publication number: 20200001536
    Abstract: An integrated additive manufacturing system includes: (a) at least one resin supply (41); (b) a plurality of additive manufacturing machines (43) on which parts may be produced, each of said additive manufacturing machines (43) operatively associated with said at least one resin supply (41); and (c) at least one peripheral machine operatively associated with each of said additive manufacturing machines and said at least one resin supply, wherein said at least one peripheral machine comprises a part fixturing apparatus (200).
    Type: Application
    Filed: March 12, 2018
    Publication date: January 2, 2020
    Inventors: Joseph M. DeSimone, Roy Goldman, Steven Kenneth Pollack, Yongqiang Li
  • Patent number: 10517824
    Abstract: The presently disclosed subject matter describes the use of fluorinated elastomer-based materials, in particular perfluoropolyether (PFPE)-based materials, in high-resolution soft or imprint lithographic applications, such as micro- and nanoscale replica molding, and the first nano-contact molding of organic materials to generate high fidelity features using an elastomeric mold. Accordingly, the presently disclosed subject matter describes a method for producing free-standing, isolated nanostructures of any shape using soft or imprint lithography technique.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: December 31, 2019
    Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Joseph M. DeSimone, Jason P. Rolland, Benjamin W. Maynor, Larken E. Euliss, Ginger Denison Rothrock, Ansley E. Dennis, Edward T. Samulski, R. Jude Samulski