Patents by Inventor Joseph M. Fernandez
Joseph M. Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240065641Abstract: A monitor mount is configured to detachably secure a first monitor and/or a second monitor individually or concurrently. The first monitor is further configured to be detachably secured to the second monitor independently from either monitor being secured to the monitor mount. The second monitor includes a mounting area in which the first monitor is mounted, and the first monitor and the second monitor are configured such that the first monitor is interchangeably insertable into the mounting area from a first lateral direction and a second lateral direction that is opposite to the first lateral direction. Accordingly, the second monitor includes a dual-entry feature that enables the first monitor to be inserted from either lateral side of the second monitor.Type: ApplicationFiled: August 27, 2021Publication date: February 29, 2024Applicant: Drägerwerk AG & Co. KGaAInventors: Clifford M. Risher-Kelly, John C. Magill, Zachary Kurt Hennings, Thomas Swyst, Christopher Aiston, Andrew T. Provencher, Peter A. Lund, Joseph Fallon, Ricardo Luis FERNANDEZ
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METHODS AND KITS FOR THE ENRICHMENT AND DETECTION OF DNA AND RNA MODIFICATIONS AND FUNCTIONAL MOTIFS
Publication number: 20220162675Abstract: Provided herein are methods for mapping modified nucleotide residues in nucleic acids. The methods include providing a nucleic acid sample in which non-target or target modified and unmodified nucleotide residues are converted to form of a different nucleotide (such a “C” being converted to “T”). Second strand synthesis is then performed on the converted nucleic acids using a set of anchored-base primers. Each primer in the set of anchored-base primers comprises one or more anchor bases at the 3? terminus that are complementary to the target nucleotide (e.g., “G” or “CpG”), and a sequence of nucleotides selected from a set of sequences that could be a fully or partially degenerate set of sequences. For example, the sequence could be 5?-XnG-3? and/or 5?-X(n?1)CG-3?, wherein X is any base, and n=2 to 25. Double-stranded nucleic acid products can be analyzed, for example by amplification and high throughput sequencing.Type: ApplicationFiled: December 23, 2020Publication date: May 26, 2022Applicants: Active Motif, Inc., Active Motif, Inc.Inventors: Benjamin F. DELATTE, Eddie W. ADAMS, Joseph M FERNANDEZ -
Publication number: 20220162676Abstract: Provided herein is a new molecular marker in DNA: N-4-acetyldeoxycytidine (“N4-acdC”). Also provided herein are methods of detecting N4-acdC residues in DNA molecules as well as methods of using detected N4-acdC residues, for example in genetic mapping and diagnostics.Type: ApplicationFiled: December 22, 2020Publication date: May 26, 2022Inventors: Benjamin F. DELATTE, Mikhail Tchoub, Eddie W. ADAMS, Joseph M FERNANDEZ
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Patent number: 10837142Abstract: Coating compositions, including high degree of substitution (DS), viscosity optimized starches, are disclosed for use in non-barrier paper coatings. Paper coated with the same is disclosed as well as methods of making the coating compositions and coated papers.Type: GrantFiled: December 14, 2018Date of Patent: November 17, 2020Assignee: SAPPI NORTH AMERICA, INC.Inventors: Joseph M. Fernandez, Arbin Rajbanshi, Qi Wang
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Publication number: 20200190222Abstract: Degraded hydroxyalkylated starches and methods of preparing the same from waxy, normal, or modified starches are provided. The starches can be prepared by several approaches that involve acid or enzyme degrading either before or after starch modification with an alkylene oxide. The modified and degraded starches exhibit improved swelling characteristics, solution stability of cooked starch, improved film-forming properties and/or improved coating performance. In addition, the degraded hydroxyalkylated starches can be used as a fat replacement in foods, in film-forming compositions, in coating compositions, and to encapsulate other materials.Type: ApplicationFiled: December 14, 2018Publication date: June 18, 2020Inventors: Yong-Cheng Shi, Joseph M. Fernandez, Arbin Rajbanshi, Qi Wang, Zhenhua Sun
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Publication number: 20200190740Abstract: Coating compositions, including high degree of substitution (DS), viscosity optimized starches, are disclosed for use in non-barrier paper coatings. Paper coated with the same is disclosed as well as methods of making the coating compositions and coated papers.Type: ApplicationFiled: December 14, 2018Publication date: June 18, 2020Inventors: Joseph M. FERNANDEZ, Arbin RAJBANSHI, Qi WANG
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Patent number: 8637264Abstract: Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding affinity for a specific target antigen. A method of determining gene expression at the protein level by contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds also is provided. This method can be used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. In addition, a method of determining gene expression at the protein level by contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds is provided.Type: GrantFiled: June 30, 2011Date of Patent: January 28, 2014Assignee: Life Technologies CorporationInventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
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Publication number: 20120004131Abstract: Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding affinity for a specific target antigen. A method of determining gene expression at the protein level by contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds also is provided. This method can be used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. In addition, a method of determining gene expression at the protein level by contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds is provided.Type: ApplicationFiled: June 30, 2011Publication date: January 5, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
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Patent number: 7794946Abstract: The invention disclosed herein comprises methods of using microarrays to simplify analysis and characterization of genes and their function. In one aspect of the invention the methods are used to identify and characterize antibodies having binding affinity for a specific target antigen. The invention further comprises a method of determining gene expression at the protein level comprising contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds. This method can be additionally used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells.Type: GrantFiled: February 4, 1999Date of Patent: September 14, 2010Assignee: Life Technologies CorporationInventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
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Publication number: 20100022407Abstract: Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding affinity for a specific target antigen. A method of determining gene expression at the protein level by contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds also is provided. This method can be used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. In addition, a method of determining gene expression at the protein level by contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds is provided.Type: ApplicationFiled: June 23, 2009Publication date: January 28, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
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Publication number: 20040229063Abstract: A coated printing sheet is provided that is suitable for conventional offset printing grades, exhibiting desirable surface and optical properties and providing a surface that is image receptive and resistant to coating failure. The coated printing sheet includes an image receptive coating containing a hard polymer pigment having a shear modulus of at least 5.0×109 dynes/cm2 and a film forming binder. The coated printing sheets resist burnishing and exhibit desirable properties, e.g., gloss, bulk, stiffness and smoothness, with minimal or no calendering.Type: ApplicationFiled: June 23, 2004Publication date: November 18, 2004Applicant: S.D. WARREN SERVICES COMPANY, a Delaware corporationInventors: Paul W. Concannon, Paul Durocher, Joseph M. Fernandez, Lisa A. Gubrud, Thomas A. Waecker
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Patent number: 6777075Abstract: A coated printing sheet is provided that is suitable for conventional offset printing grades, exhibiting desirable surface and optical properties and providing a surface that is image receptive and resistant to coating failure. The coated printing sheet includes an image receptive coating containing a hard polymer pigment having a shear modulus of at least 5.0×109 dynes/cm2 and a film forming binder. The coated printing sheets resist burnishing and exhibit desirable properties, e.g., gloss, bulk, stiffness and smoothness, with minimal or no calendering.Type: GrantFiled: March 15, 2002Date of Patent: August 17, 2004Assignee: S.D. Warren Services CompanyInventors: Paul W. Concannon, Paul Durocher, Joseph M. Fernandez, Lisa A. Gubrud, Thomas A. Waecker
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Publication number: 20040009477Abstract: The present invention comprises a method for producing libraries of expressible gene sequences. The method of the invention allows for the simultaneous manipulation of multiple gene sequences and thus allows libraries to be created in an efficient and high throughput manner. The expression vectors containing verified gene sequences can be used to transfect cells for the production of recombinant proteins. The invention further comprises libraries of expressible gene sequences produced using the method of the invention and expression vectors used in the construction of said libraries.Type: ApplicationFiled: November 21, 2001Publication date: January 15, 2004Applicant: INVITROGEN CORPORATIONInventors: Joseph M. Fernandez, John A. Heyman, James P. Hoeffler, Heather L. Marks-Hull, Michelle L. Sindici
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Publication number: 20030175501Abstract: A coated printing sheet is provided that is suitable for conventional offset printing grades, exhibiting desirable surface and optical properties and providing a surface that is image receptive and resistant to coating failure. The coated printing sheet includes an image receptive coating containing a hard polymer pigment having a shear modulus of at least 5.0×109 dynes/cm2 and a film forming binder. The coated printing sheets resist burnishing and exhibit desirable properties, e.g., gloss, bulk, stiffness and smoothness, with minimal or no calendering.Type: ApplicationFiled: March 15, 2002Publication date: September 18, 2003Inventors: Paul W. Concannon, Paul Durocher, Joseph M. Fernandez, Lisa A. Gubrud, Thomas A. Waecker
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Publication number: 20020164656Abstract: Methods of using microarrays to simplify analysis and characterization of genes and their function are provided. Such methods can be used to identify and characterize antibodies having binding affinity for a specific target antigen. A method of determining gene expression at the protein level by contacting an array of characterized or uncharacterized antibodies on a solid surface with one or more proteins and identifying the antibodies to which said protein(s) binds also is provided. This method can be used to compare the protein expression in two different populations of cells, such as normal cells and cancer cells or resting cells and stimulated cells. In addition, a method of determining gene expression at the protein level by contacting a microarray of nucleic acid samples derived from a variety of different sources with one or more nucleic acid probes then identifying the sample or samples to which the probe binds is provided.Type: ApplicationFiled: October 26, 2001Publication date: November 7, 2002Inventors: James P. Hoeffler, Joseph M. Fernandez, Marc S. Nasoff
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Patent number: 5827657Abstract: Methods are described for producing recombinant DNA molecules from suitable host vectors and nucleic acids subjected to 3'-terminal transferase activity. In one embodiment, the method takes advantage of the single 3'-deoxy-adenosine monophosphate (dAMP) residues attached to the 3' termini of PCR generated nucleic acids. Vectors are prepared with recognition sequences that afford single 3'-terminal deoxy-thymidine monophosphate (dTMP) residues upon reaction with a suitable restriction enzyme. Thus, PCR generated copies of genes can be directly cloned into the vectors without need for preparing primers having suitable restriction sites therein. The invention also contemplates associated plasmid vectors and kits for implementing the methods.Type: GrantFiled: July 18, 1996Date of Patent: October 27, 1998Assignees: Invitrogen Corporation, Molecular Biology Resources, Inc.Inventors: Corinna Herrnstadt, Joseph M. Fernandez, Lloyd Smith, David A. Mead
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Patent number: 5487993Abstract: Methods are described for producing recombinant DNA molecules from suitable host vectors and nucleic acids subjected to 3'-terminal transferase activity. In one embodiment, the method takes advantage of the single 3'-deoxy-adenosine monophosphate (dAMP) residues attached to the 3' termini of PCR generated nucleic acids. Vectors are prepared with recognition sequences that afford single 3'-terminal deoxy-thymidine monophosphate (dTMP) residues upon reaction with a suitable restriction enzyme. Thus, PCR generated copies of genes can be directly cloned into the vectors without need for preparing primers having suitable restriction sites therein. The invention also contemplates associated plasmid vectors and kits for implementing the methods.Type: GrantFiled: September 9, 1993Date of Patent: January 30, 1996Assignees: Invitrogen Corporation, ChimerInventors: Corinna Herrnstadt, Joseph M. Fernandez, Lloyd Smith, David A. Mead
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Patent number: 4395499Abstract: High strength pigment binders for paper coating having increased water retention and stability are disclosed. The coating compositions comprise an aqueous synthetic polymer latex and pigment and may contain other additives used in the art of pigmented paper coating. The latex comprises a dispersed interpolymer of a vinyl ester, a polyethylenically unsaturated comonomer and a ethylenically unsaturated mono- or dicarboxylic acid and optionally an alkyl acrylate.Type: GrantFiled: September 13, 1982Date of Patent: July 26, 1983Assignee: National Starch And Chemical CorporationInventors: Josephine M. Rosenski, Joseph M. Fernandez