Abstract: Components of interest are captured on a resin column from a sample of exhaust gas from an operating vehicle. Makeup air is added to the residual exhaust gas flow exiting the resin column at a junction downstream of the resin column. Makeup air flow rate is determined using a laminar flow element and pressure and temperature gauges associated therewith. The sample and the makeup air are drawn together through a blower and the flow rate through the blower is calculated based on differential pressure across the blower and temperature of the gas drawn through the blower. The controller adjusts a proportional control valve in the makeup air line to regulate the sample flow rate, taken as the blower flow rate minus the makeup air flow rate, at a predetermined proportion of the exhaust gas flow rate.

Abstract: According to an embodiment, a build server device includes a processor, data storage, and a plurality of modules including a receiving module, a generating module and an initiation module. The receiving module is configured to receive information regarding a server cluster including at least an indication of a front end server of the server cluster. The generating module is configured to generate a data set based on the received information. The initiation module is configured to provide the generated data set to the front end server, provide an instruction to the front end server to facilitate the front end server automatically initiating itself based on the generated data set.

Abstract: Components of interest are captured on a resin column from a sample of exhaust gas from an operating vehicle. Makeup air is added to the residual exhaust gas flow exiting the resin column at a junction downstream of the resin column. Makeup air flow rate is determined using a laminar flow element and pressure and temperature gauges associated therewith. The sample and the makeup air are drawn together through a blower and the flow rate through the blower is calculated based on differential pressure across the blower and temperature of the gas drawn through the blower. The controller adjusts a proportional control valve in the makeup air line to regulate the sample flow rate, taken as the blower flow rate minus the makeup air flow rate, at a predetermined proportion of the exhaust gas flow rate.

Abstract: A collapsible shipping container includes a floor, a roof, and a pair of bifolding sidewalls, that collapse accordion style to place the sidewalls and roof in a configuration wherein the roof is collapsed onto the sidewalls, and the sidewalls are collapsed onto the floor. The container further includes a pair of end walls having upper and lower end wall sections. The upper end wall sections may be lowered by activation of a power source to lie on the roof in the collapsed configuration. Collapse and erection of the shipping container may be accomplished with the aid of auxiliary equipment, such as a fork lift.

Abstract: A torque limiting clutch includes a drive shaft having central rotational axis, a disk-shaped spring member secured to the drive shaft for rotation therewith, and a plate adjacent the spring member and having a plurality of grooves receiving bosses of the spring member. The spring member has a plurality bosses formed at an outer edge of the spring member that each form a generally V-shaped engagement surface. The grooves each form a generally V-shaped engagement surface engaging the bosses. A retaining clip retains the plate relative to the spring member to obtain a predetermined spring pretension. Engagement of the bosses with the grooves causes rotation of the plate upon rotation of the drive shaft when below a predetermined torque limit and deflection of the bosses out of the grooves prevents rotation of the plate upon rotation of the drive shaft when above the predetermine torque.

Abstract: A collapsible shipping container includes a floor, a roof, and a pair of bifolding sidewalls, that collapse accordion style to place the sidewalls and roof in a configuration wherein the roof is collapsed onto the sidewalls, and the sidewalls are collapsed onto the floor. The container further includes a pair of end walls having upper and lower end wall sections. The upper end wall sections may be lowered by activation of a power source to lie on the roof in the collapsed configuration. Collapse and erection of the shipping container may be accomplished with the aid of auxiliary equipment, such as a fork lift.

Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human inmmunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: Selected heterocyclecarbonyl amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, compositions, and methods for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: Selected amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: A jack handle includes a handle arm having first and second ends, a jack driver having a coupling shaft, and a spring clip detachably securing the jack driver to the handle arm. The first end of the handle arm forms a socket receiving the coupling shaft. The spring clip has a protrusion resiliently deflectable between a locking position interlocking with the coupling shaft to secure the jack driver to the handle arm and a releasing position free of the coupling shaft such that the jack driver is released from the handle arm. Preferably, the spring clip encircles the periphery of the handle arm at the socket, the handle arm has an opening at the socket, and the protrusion of the clip extends through the opening and into the groove to interlock the jack driver with the handle arm.

Abstract: A treatment process is disclosed that comprises administering an effective amount of an aromatic sulfone hydroxamic acid that exhibits excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP-1 to a host having a condition associated with pathological matrix metalloprotease activity. The administered enzyme inhibitor corresponds in structure to formula (I), below, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are both hydrido or R1 and R2 together with the atoms to which they are bonded form a 5- to 8-membered ring containing one, two, or three heteroatoms in the ring that are oxygen, sulfur, or nitrogen. R3 in formula (I) is an optionally substituted aryl or optionally substituted heteroaryl radical.

Abstract: This invention is directed generally to hydroxamic acid and amide compounds (including salts of such compounds), and, more particularly, to aryl- and heteroaryl-arylsulfonylmethyl hydroxamic acids and amides that, inter alia, inhibit protease activity, particularly matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. These compounds generally correspond in structure to Formula I: wherein A1, A2, A3, E1, E2, E3, and E4 are as defined in this patent. This invention also is directed to compositions of such compounds, intermediates for the syntheses of such compounds, methods for making such compounds, and methods for treating conditions associated with MMP activity and/or aggrecanase activity, particularly pathological conditions.

Abstract: A pantograph jack includes a base, a load rest, first and second lower arms each pivotably coupled at a first end to the base, and first and second upper arms each pivotably coupled at a first end to the load rest. Second ends of the first lower and upper arms are pivotably coupled at a first joint. Second ends of the second lower and upper arms are pivotably coupled at a second joint. A screw extends between the joints and operably moves the joints toward and away from each other upon rotation of the screw to raise and lower the load rest. A bearing spacer includes a flange forming a bearing engagement surface at a first end and a second end engaging the second joint. The drive screw has an abutment facing the bearing engagement surface. A bearing is located between the bearing engagement surface and the abutment.

Abstract: Selected bis-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Abstract: This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. Such hydroxamic acids generally correspond in structure to the following formula: (wherein A1, A2, Y, E1, E2, E3, and Rx are as defined in this specification), and further include salts of such compounds. This invention also is directed to compositions of such hydroxamic acids, intermediates for the syntheses of such hydroxamic acids, methods for making such hydroxamic acids, and methods for treating conditions (particularly pathological conditions) associated with MMP activity and/or aggrecanase activity.

Abstract: This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

Abstract: This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

Abstract: A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a contemplated sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound in a MMP enzyme-inhibiting effective amount to a host having a condition associated with pathological matrix metalloprotease activity.