Patents by Inventor Joseph Michael McIntosh

Joseph Michael McIntosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240269228
    Abstract: Disclosed herein are compositions and methods related to RgIA4 peptide analogs. An RgIA4 peptide analog can comprise a recognition finger region configured to bind to an ?9?10 nicotinic acetylcholine receptor. The RgIA4 peptide analog can comprise at least two disulfide bridges comprising: an inter-cysteine disulfide bridge between a first cysteine and a second cysteine, and a penicillamine-cysteine disulfide bridge between a first penicillamine and a third cysteine. The RgIA4 peptide analog can have a binding affinity for the ?9?10 nicotinic acetylcholine receptor that is at least 50% of a binding affinity of an RgIA4 peptide. A method of maintaining an RgIA4 peptide potency for an ?9?10 nicotinic acetylcholine receptor in an RgIA4 peptide analog can comprise providing a composition as disclosed herein. A method for treating a condition responsive to ?9?10 nicotinic acetylcholine receptor binding can comprise administering a therapeutically effective amount of the composition to the subject.
    Type: Application
    Filed: March 16, 2022
    Publication date: August 15, 2024
    Inventors: Joanna Gajewiak, Joseph Michael McIntosh
  • Publication number: 20230391838
    Abstract: ?-RgIA4 peptide analogs, compositions therewith, and methods for their treatment and use are disclosed and described. For example, an ?-RgIA4 peptide analog can comprise a recognition finger region configured to bind to an ?9?10 nicotinic acetylcholine receptor, and a side chain bonding configuration that protects an inter-cysteine sulfur linkage.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 7, 2023
    Inventors: Joseph Michael McIntosh, Nan Zheng, Hung-Chieh Chou