Abstract: Disclosed herein are compounds of formula (I) and therapeutic methods of treatment with compounds of formula (I), wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification. Compounds of formula (I) are EP4 agonists useful in the treatment of glaucoma, neuropathic pain, and related disorders.

Abstract: An end effector includes a distal clevis, an axle mounted to the distal clevis, a first jaw holder and corresponding first jaw member rotatably mounted to the axle, and second jaw holder and corresponding second jaw member rotatably mounted to the axle. A cylindrical sleeve axle having opposing first and second ends and defining a central passageway extending between the opposing first and second ends, the sleeve axle providing a continuously straight and uninterrupted outer surface extending entirely between the opposing first and second ends. The axle is received within the central passageway and the sleeve axle is rotatable relative to the axle.

Abstract: A seating assembly is provided with swivel capabilities. The seating assembly includes a coupling member, a seat, a seatback, and a swivel plate. The seat is pivotably coupled to the coupling member. The seatback is also pivotably coupled to the coupling member. Additionally, the swivel plate is coupled to the coupling member.

Abstract: A polycrystalline CVD synthetic diamond material is provided that has an average thermal conductivity at room temperature through a thickness of the polycrystalline CVD synthetic diamond material of between 1700 and 2400 Wm?1K?1, a thickness of at least 2.5 mm and a visible transmittance through the thickness of the polycrystalline CVD synthetic diamond of at least 25%. A wafer comprising the material is also provided, wherein at least 70% of a total area of the wafer has the properties of the polycrystalline CVD synthetic diamond material. A method for fabricating the wafer is also disclosed.

Abstract: A wireless communication system includes a plurality of sensors and a device. Each sensor is configured to measure data and communicate over a network using low power signal communication. The device is connected to an in-wall power source and configured to wirelessly communicate over the network using low power signal communication. Further, the device is configured to transmit data from the sensors to a remote gateway using high power signal communication.

Abstract: Methods, systems, and non-transitory computer-readable media are configured to perform operations comprising determining a rescue lane scenario for an environment, determining an amount of lateral bias for a vehicle, and generating planning and control data for the vehicle to laterally bias based on the amount of lateral bias.

Abstract: Aspects disclosed herein relate to a method comprising: obtaining a list of data paths to at least one persistent storage device through a plurality of NUMA nodes; associating with each data path, access performance information; receiving a request to access one of the at least one persistent storage device; calculating a preferred data path to the one of the at least one persistent storage device using the access performance information; and accessing the one of the at least one persistent storage device using the preferred data path.

Abstract: A method of detecting a stimulus can include detecting an output from a radio frequency identification tag including a sensor. A smartphone-based sensing strategy can use chemiresponsive nanomaterials integrated into the circuitry of commercial Near Field Communication tags to achieve non-line-of-sight, portable, and inexpensive detection and discrimination of gas phase chemicals (e.g., ammonia, hydrogen peroxide, cyclohexanone, and water) at part-per-thousand and part-per-million concentrations.

Abstract: Aspects of the present disclosure relate to an apparatus comprising processing circuitry, first cache circuitry and second cache circuitry, wherein the second cache circuitry has an access latency higher than an access latency of the first cache circuitry. The second cache circuitry is responsive to receiving a request for data stored within the second cache circuitry to identify said data as pseudo-invalid data and provide said data to the first cache circuitry. The second cache circuitry is responsive to receiving an eviction indication, indicating that the first cache circuitry is to evict said data, to, responsive to determining that said data has not been modified since said data was provided to the first cache circuitry, identify said pseudo-invalid data as valid data.

Abstract: The present invention relates to antibodies binding to IL22 and inhibiting its interaction with one or more of its natural ligands Specific examples of such antibodies are provided. The therapeutic uses of the antibodies and methods of generating such C are also provided.

Abstract: There is provided a data processing apparatus comprising history storage circuitry that stores sets of behaviours of helper instructions for a control flow instruction. Pointer storage circuitry stores pointers, each associated with one of the sets. The behaviours in the one of the sets are indexed according to one of the pointers associated with that one of the sets. Increment circuitry increments at least some of the pointers in response to an increment event and prediction circuitry determines a predicted behaviour of the control flow instruction using one of the sets of behaviours.

Abstract: A system is described that permits identified musical phrases or themes to be synchronized and linked into changing real-world events. The achieved synchronization includes a seamless musical transition—achieved using a timing offset, such as relative advancement of an significant musical “onset,” that is inserted to align with a pre-existing but identified music signature, beat or timebase—between potentially disparate pre-identified musical phrases having different emotive themes defined by their respective time signatures, intensities, keys, musical rhythms and/or musical phrasing. The system operates to augment an overall sensory experience of a user in the real world by dynamically changing, re-ordering or repeating and then playing audio themes within the context of what is occurring in the surrounding physical environment, e.g. during different phases of a cardio workout in a step class the music rate and intensity increase during sprint periods and decrease during recovery periods.

Abstract: Disclosed herein are embodiments of a spinal implant having structures that incorporate a solid material and a porous material. The solid material provides the implant with an outer shell for structural integrity while the porous material, distributed within an interior of the implant as a lattice structure for example, promotes visibility of the implant in radiological imaging, promotes bony ingrowth and cell attachment and improves wicking.

Abstract: A seat assembly includes a seat portion having a frame assembly. A routing mechanism includes a plate member that is operably coupled to the frame assembly. The plate member includes a first portion having first and second raised portions spaced-apart from one another to define a channel therebetween. The routing mechanism further includes a connection assembly having upper and lower tabs spaced-apart from one another with a routing column assembly interconnecting the upper and lower tabs. A tether member includes a body portion that is routed through the routing mechanism, in that the body portion of the tether member is received in the channel of the routing mechanism and is wrapped around the routing column assembly and directed in forward direction.

Abstract: A seat assembly includes a seat portion having a frame assembly, a carrier assembly and a displaceable platform operably coupled to the carrier assembly. The displaceable platform is operable between a use position and a deployed position. A retraction mechanism includes a first bracket operably coupled to the frame assembly, and a second bracket operably coupled to the displaceable platform. The first and second brackets are interconnected by an actuator that is operable between at-rest and actuated positions. The second bracket moves from a first position to a second position as the actuator moves from the at-rest position to the actuated position. At least one tether member is operably coupled to the first bracket and includes a body portion interlaced between the first and second brackets of the retraction mechanism.

Abstract: Modular circuit protection devices and configurable panelboard systems include arc-free operation, thermal management features providing safe operation in hazardous environments at lower cost and without requiring conventional explosion-proof enclosures and without entailing series connected separately provided packages such as circuit breaker devices and starter motor contactors and controls.

Abstract: A seat assembly includes a seatback having an interior portion with a seatback frame disposed therein. A retraction mechanism includes a first bracket operably coupled to the seatback frame. A second bracket is operably coupled to the first bracket by an actuator that is operable between at-rest and actuated positions. A tether member includes a body portion that is operably coupled between the first and second brackets of the retraction mechanism for movement therewith. The tether member moves from a deployed position to a retracted position when the actuator moves from the at-rest position to the actuated position. A belt member is operably coupled to the tether member. The belt member is operable between a deployed position, wherein the belt member is disposed in front of the back support portion of the seatback, and a stowed position, wherein the belt member is received in the interior portion of the seatback.

Abstract: Disclosed is a method and system, in FIG. 1, for verifying authenticity of specific personal data responsive to a unique wallet address (70) on a public ledger (66) of an unregulated platform (60). The wallet contains one or more non-transferable NFTs each locked to the wallet and related to specific personal data. The non-transferable NFT was minted from a regulated platform (27) to which there is a record (76) in the public ledger. Supplying the unique address of the wallet to a service supplier affects a log-in of a client (18) to the service supplier (90), whereafter message interactions over a network (12) between the service supplier and the unregulated platform (60) permits searching for a relevant (72) non-transferable NFTs (74) stored in the wallet and related to the specific personal data. Return of any relevant non-transferable NFT related to the personal data thus verifies authenticity of the specific personal data by association with a regulated platform.

Abstract: The present invention relates to a filter unit suitable for filtering microfibres within a feed, especially a feed originating from a textile treatment apparatus. The present invention also relates to a textile treatment apparatus comprising said filter unit and a method of filtering utilising said filter unit.

Abstract: Disclosed is a method and system, in FIG. 1, for verifying authenticity of specific personal data responsive to a unique wallet address (70) on a public ledger (66) of an unregulated platform (60). The wallet contains one or more non-transferable NFTs each locked to the wallet and related to specific personal data. The non-transferable NFT was minted from a regulated platform (27) to which there is a record (76) in the public ledger. Supplying the unique address of the wallet to a service supplier affects a log-in of a client (18) to the service supplier (90), whereafter message interactions over a network (12) between the service supplier and the unregulated platform (60) permits searching for a relevant (72) non-transferable NFTs (74) stored in the wallet and related to the specific personal data. Return of any relevant non-transferable NFT related to the personal data thus verifies authenticity of the specific personal data by association with a regulated platform.