Abstract: Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections. The tissue adjustment implants can be used in a variety of treatments, such as in the treatment of Obstructive Sleep Apnea and snoring.

Abstract: Described are medical graft products, systems, and methods for treating fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening, e.g., one occurring in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member, which is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and an elongate plug member extending from the capping member, which is configured to extend into at least a portion of the fistula. In certain embodiments, a graft body component has the capacity to expand or otherwise change form to provide a suitable capping arrangement. Such a component can include a resilient wire frame, e.g., one that is self-expandable or one that requires at least some manipulation in order to expand.

Abstract: Example lithotripsy probe assemblies, lithotripsy systems, and methods of using a lithotripsy system are described. An example lithotripsy probe assembly has a probe coupling, a probe, and a plurality of sealing members disposed on the probe coupling. The probe coupling has a probe coupling proximal end, a probe coupling distal end, a probe coupling length, and a probe coupling main body that defines a plurality of projections, a probe coupling first passageway, and a probe coupling second passageway. The probe coupling length extends from the probe coupling proximal end to the probe coupling distal end. The probe is attached to the probe coupling and is partially disposed within the probe coupling first passageway. The probe has a probe proximal end, a probe distal end, and a probe length that extends from the probe proximal end to the probe distal end and is greater than the probe coupling length.

Abstract: Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.

Abstract: Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections. The tissue adjustment implants can be used in a variety of treatments, such as in the treatment of Obstructive Sleep Apnea and snoring.

Abstract: Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections. The tissue adjustment implants can be used in a variety of treatments, such as in the treatment of Obstructive Sleep Apnea and snoring.

Abstract: Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.

Abstract: Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

Abstract: Described are stent graft devices and methods for their preparation and use. Expandable stent graft devices of the invention include inner and/or outer coverings uniquely applied and associated with surfaces of the stent. In certain described embodiments, bioremodelable materials such as ECM materials are vacuum pressed onto and/or around elements of a stent in the manufacture of a stent graft device.

Abstract: Described are medical graft products, systems, and methods useful for treating fistulae, particularly enterocutaneous fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member connected to an elongate plug member. The capping member is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and the elongate plug member is configured to extend into at least a portion of the fistula. A graft product of this sort may be particularly adapted to allow a portion of the capping member to be positioned alongside an exterior, lateral surface of the plug member, e.g., when placed in a delivery device lumen. Such a capping member may be hingedly or non-hingedly coupled to the elongate plug member.

Abstract: A system for monitoring the flow of blood within an endoluminal passage is provided comprising a medical device and a sensor. The medical device is implantable within the endoluminal passage and includes a shaft and an expandable segment coupled to the shaft. The expandable segment is movable between a first state and a second state. Movement of the expandable segment is responsive to a change in the fluid pressure external to the expandable segment. The sensor is positioned on the medical device and is adapted to collect information associated with the state of the expandable segment.

Abstract: A vascular pulsation device may be provided including a pulsation portion and a reservoir portion. The pulsation portion may be insertable into a bodily passageway and may include an expandable segment, a first end, and a second end. The reservoir portion may be in fluid connection with the pulsation portion by a supply passage and a return passage. An opening of the supply passage may be positioned proximate to the second end of the pulsation portion. An opening of the return passage may be positioned proximate to the first end of the pulsation portion.

Abstract: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.

Abstract: A filamentous graft has an elongate filament body including one or more intact segments of a decellularized collagenous tissue membrane. The graft can have a length of at least about 20 cm. The graft can be cut from a laminate of two or more decellularized collagenous tissue membranes. The graft can have a generally rectangular cross-section and can have substantially uniform dimensions and tensile strength along at least a substantial portion of its length. Methods for preparing and using filamentous grafts are also described.

Abstract: Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections. The tissue adjustment implants can be used in a variety of treatments, such as in the treatment of Obstructive Sleep Apnea and snoring.

Abstract: Described are medical products, systems, and methods for treating fistulae having a primary opening, such as in the alimentary canal. Certain methods of the invention include providing an implantable material including a compliant sheet form biocompatible material, and forcing this sheet form biocompatible material into the primary opening so as to deform the sheet form biocompatible material to conform to and block the primary opening. The biocompatible material preferably comprises a remodelable material, for example, a remodelable extracellular matrix material such as submucosa.

Abstract: Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.

Abstract: Disclosed are electrostimulative grafts that include at least one galvanic couple with an anode spaced from a cathode. The anode and cathode can be made from biodegradable metals. The graft can include a porous graft matrix material receptive to tissue ingrowth that occurs between the anode and cathode. The electrostimulation provided by the galvanic couple after implantation of the graft can impact the development of tissue within and/or around the porous graft matrix material. Also disclosed are methods for making electrostimulative grafts and for galvanically electrostimulating tissue growth in a porous graft matrix material.

Abstract: Tissue adjustment implants useful for adjusting a position of tissue in a patient are described. In an embodiment, a tissue adjustment implant includes a main body having a series of outwardly-extending projections. The tissue adjustment implants can be used in a variety of treatments, such as in the treatment of Obstructive Sleep Apnea and snoring.

Abstract: Described are expanded collagenous materials and methods for their preparation and use. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.