Patents by Inventor Joseph P. Skinner

Joseph P. Skinner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10775401
    Abstract: Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: September 15, 2020
    Assignee: Abbott Molecular Inc.
    Inventors: Jason E. Bryant, Daniel P. Casazza, Daniel J. Harris, Brett W. Johnson, Sonal Sadaria Nana, Timothy J. Patno, Frank Pawlowski, David M. Peters, Joseph P. Skinner, Mark Talmer
  • Publication number: 20190376963
    Abstract: The disclosure provides a method for an enhanced detection of an analyte present in a biological sample. After the formation of the analyte/specific binding member(s)/detectable label complex, the labels are eluted and a first aliquot of eluant is brought into contact with a solid support, wherein the solid support comprises immobilized thereto specific binding member that specifically binds to the label, removing the first aliquot from the solid support and contacting the solid support with a second aliquot of the eluted label, and repeating the above steps, such that the label is concentrated on the solid support for further analysis to quantify the analyte in the biological sample.
    Type: Application
    Filed: May 3, 2019
    Publication date: December 12, 2019
    Inventors: Sergey Tetin, Jeffrey B. Huff, Joseph P. Skinner, Patrick MacDonald, Qiaoqiao Ruan
  • Publication number: 20190195798
    Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
    Type: Application
    Filed: December 31, 2018
    Publication date: June 27, 2019
    Inventors: Qiaoqiao Ruan, Sylvia C. Saldana, Joseph P. Skinner, Sergey Y. Tetin
  • Patent number: 10190986
    Abstract: A method for analyzing the results of a ligand-receptor binding assay comprising the steps of: (a) providing the results of a ligand-receptor binding assay; and (b) qualifying the results of a ligand-receptor binding assay. More particularly, the ligand-receptor binding assay involves the steps of combining appropriate reagents in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is directly proportional to the amount of ligand present in the sample. Alternatively, the ligand-receptor binding assay involves the steps of combining appropriate reagents to perform a ligand-receptor binding assay in which receptors attached to a solid support, a sample suspected of containing a ligand, and a conjugate comprising a label form a complex in which the label is present at a concentration that is inversely proportional to the amount of analyte present in the sample.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: January 29, 2019
    Assignee: Abbott Laboratories
    Inventors: Qiaoqiao Ruan, Sylvia C. Saldana, Joseph P. Skinner, Sergey Y. Tetin
  • Publication number: 20190004041
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Application
    Filed: August 8, 2018
    Publication date: January 3, 2019
    Applicant: ABBOTT LABORATORIES
    Inventors: Barry L. DOWELL, Susan GAYDA, Qiaoqiao RUAN, Joseph P. SKINNER, Sergey Y. TETIN
  • Patent number: 10073090
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: September 11, 2018
    Assignee: ABBOTT LABORATORIES
    Inventors: Barry L. Dowell, Susan Gayda, Qiaoqiao Ruan, Joseph P. Skinner, Sergey Y. Tetin
  • Publication number: 20170335408
    Abstract: The instant disclosure provides methods of multi-assay processing and multi-assay analysis. Such multi-assay processing and analysis pertain to automated detection of target nucleic acids, e.g., as performed in the clinical setting for diagnostic purposes. Also provided are common assay timing protocols derived from a variety of individual nucleic acid amplification and analysis protocols and modified to prevent resource contention. The instant disclosure also provides systems and devices for practicing the methods as described herein.
    Type: Application
    Filed: March 15, 2017
    Publication date: November 23, 2017
    Inventors: Frank Pawlowski, Joseph P. Skinner, Jack Kessler, Sonal Sadaria Nana
  • Publication number: 20170268038
    Abstract: Aspects of the present disclosure include sample preparation cartridges including a frame that includes a plurality of wells integrated therewith, where the plurality of wells have a closed bottom and an open top. The frame further includes an opening within the frame having a reaction vessel (RV) or RV cap removably disposed therein, where the plurality of wells and the opening are linearly arranged relative to each other. Also provided are sample preparation cartridges that include a frame, two or more cartridge separation projections on a top side of the frame, and two or more cartridge separation projections on a bottom side of the frame. The cartridge separation projections separate the cartridge and a different cartridge when the cartridge and different cartridge are stacked. Methods of using the sample preparation cartridges, as well as nucleic acid sample preparation units that include the sample preparation cartridges, are also provided.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Timothy P. Henning, Joseph P. Skinner, Jody L. Keck, Chadwick M. Dunn, Wesley W. Addison, II, Timothy J. Patno, Sonal Sadaria Nana, Mark Talmer, Austin Lines, Daniel J. Harris, Eric D. Yeaton
  • Publication number: 20170269114
    Abstract: Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.
    Type: Application
    Filed: March 15, 2017
    Publication date: September 21, 2017
    Inventors: Jason E. Bryant, Daniel P. Casazza, Daniel J. Harris, Brett W. Johnson, Sonal Sadaria Nana, Timothy J. Patno, Frank Pawlowski, David M. Peters, Joseph P. Skinner, Mark Talmer
  • Patent number: 9575076
    Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: October 29, 2015
    Date of Patent: February 21, 2017
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Patent number: 9575077
    Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: October 30, 2015
    Date of Patent: February 21, 2017
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Publication number: 20160109465
    Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Application
    Filed: October 29, 2015
    Publication date: April 21, 2016
    Applicant: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Publication number: 20160109466
    Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Application
    Filed: October 30, 2015
    Publication date: April 21, 2016
    Applicant: Abbott Point of Care Inc.
    Inventors: Dan WANG, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Publication number: 20160054317
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Application
    Filed: September 2, 2015
    Publication date: February 25, 2016
    Applicant: ABBOTT LABORATORIES
    Inventors: Barry L. DOWELL, Susan GAYDA, Qiaoqiao RUAN, Joseph P. SKINNER, Sergey Y. TETIN
  • Patent number: 9199234
    Abstract: The invention relates to antibody characteristics used to design a whole blood Point of Care Thyroid Stimulating Hormone (TSH) immunoassay using an ELISA sandwich assay lacking one or more wash steps between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Patent number: 9201078
    Abstract: The invention relates to low wash Thyroid Stimulating Hormone (TSH) immunoassays using an ELISA sandwich assay having limited or no wash step between the antigen capture, detection antibody addition and substrate introduction steps. This invention exhibits low cross reactivity with biologically similar interfering cross reacting species, such as Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and Chorionic Gonadotropin (CG).
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: December 1, 2015
    Assignee: Abbott Point of Care Inc.
    Inventors: Dan Wang, Gordon Bruce Collier, Joseph P. Skinner, Qiaoqiao Ruan, Sergey Y. Tetin
  • Patent number: 9157910
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 13, 2015
    Assignee: Abbott Laboratories
    Inventors: Barry L. Dowell, Susan Gayda, Qiaoqiao Ruan, Joseph P. Skinner, Sergey Y. Tetin
  • Patent number: 9005901
    Abstract: Provided herein are kits and methods for assays with internal calibration.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 14, 2015
    Assignee: Abbott Laboratories
    Inventors: Susan Gayda, Qiaoqiao Ruan, Joseph P. Skinner, Sergey Y. Tetin
  • Publication number: 20140273272
    Abstract: Provided herein are kits and methods for assays with internal calibration.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: ABBOTT LABORATORIES
    Inventors: Susan GAYDA, Qiaoqiao RUAN, Joseph P. SKINNER, Sergey Y. TETIN
  • Publication number: 20140273035
    Abstract: Provided herein are assays and kits useful for avoiding “prozone phenomenon” or “hook effect” and which expand the range of accurately measurable analyte concentrations.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Inventors: Barry L. DOWELL, Susan GAYDA, Qiaoqiao RUAN, Joseph P. SKINNER, Sergey Y. TETIN