Patents by Inventor Joseph R. Moskal

Joseph R. Moskal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INSULIN LIKE GROWTH FACTOR BINDING PROTEIN BIOACTIVE PEPTIDE FRAGMENTS
    Publication number: 20240124526
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: December 22, 2023
    Publication date: April 18, 2024
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • Insulin like growth factor binding protein bioactive peptide fragments
    Patent number: 11859020
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: January 2, 2024
    Assignee: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • METHODS OF TREATING DISORDERS ASSOCIATED WITH ELEVATED LEVELS OF ANTIBODIES THAT INTERACT WITH THE NMDA RECEPTOR
    Publication number: 20220273629
    Abstract: Methods of treating a disorder associated with elevated NMDAR antibodies in a patient in need thereof are provided comprising, for example, administering to the patient an effective amount of a spiro-?-lactam compound.
    Type: Application
    Filed: July 30, 2020
    Publication date: September 1, 2022
    Inventors: Joseph R. Moskal, Roger A. Kroes, Torsten M. Madsen
  • INSULIN LIKE GROWTH FACTOR BINDING PROTEIN BIOACTIVE PEPTIDE FRAGMENTS
    Publication number: 20220144896
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • NMDA RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20210332061
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Application
    Filed: December 4, 2020
    Publication date: October 28, 2021
    Inventors: M. Amin Khan, Joseph R. Moskal, Paul Wood
  • METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, AND OTHER DISORDERS
    Publication number: 20210169964
    Abstract: The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.
    Type: Application
    Filed: May 5, 2020
    Publication date: June 10, 2021
    Inventor: Joseph R. Moskal
  • NMDA receptor modulators and uses thereof
    Patent number: 10906913
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: February 2, 2021
    Assignee: Northwestern University
    Inventors: M. Amin Khan, Joseph R. Moskal, Paul Wood
  • INSULIN LIKE GROWTH FACTOR BINDING PROTEIN BIOACTIVE PEPTIDE FRAGMENTS
    Publication number: 20210009639
    Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
    Type: Application
    Filed: July 9, 2020
    Publication date: January 14, 2021
    Applicant: Northwestern University
    Inventors: Joseph R. Moskal, Jeffrey S. Burgdorf
  • METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, AND OTHER DISORDERS
    Publication number: 20190209642
    Abstract: The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.
    Type: Application
    Filed: October 23, 2018
    Publication date: July 11, 2019
    Inventor: Joseph R. Moskal
  • NMDA RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20190077807
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Application
    Filed: October 17, 2017
    Publication date: March 14, 2019
    Inventors: M. Amin Khan, Joseph R. Moskal, Paul Wood
  • METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES
    Publication number: 20190062372
    Abstract: The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
    Type: Application
    Filed: November 13, 2018
    Publication date: February 28, 2019
    Inventor: Joseph R. Moskal
  • Methods of treating depression and other related diseases
    Patent number: 10167314
    Abstract: The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: January 1, 2019
    Assignee: Northwestern University
    Inventor: Joseph R. Moskal
  • SUBACUTE ADMINISTRATION OF NMDA MODULATORS ALONE OR IN COMBINATION
    Publication number: 20180325893
    Abstract: This disclosure features combinations of NMDA modulators and atypical antipsychotics. The disclosure provides for example, methods of treating schizophrenia, bipolar disorder, and/or cognitive impairment disorder in a patient in need thereof, comprising administering e.g., rapastinel and an atypical antipsychotic.
    Type: Application
    Filed: October 14, 2016
    Publication date: November 15, 2018
    Inventors: Joseph R. Moskal, Hebert Meltzer
  • METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES
    Publication number: 20180094026
    Abstract: The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
    Type: Application
    Filed: June 5, 2017
    Publication date: April 5, 2018
    Inventor: Joseph R. Moskal
  • NMDA receptor modulators and uses thereof
    Patent number: 9802946
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorder such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 31, 2017
    Assignee: Northwestern University
    Inventors: M. Amin Khan, Joseph R. Moskal, Paul Wood
  • Methods of treating depression and other related diseases
    Patent number: 9796755
    Abstract: The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: October 24, 2017
    Assignee: Northwestern University
    Inventor: Joseph R. Moskal
  • Secondary structure stabilized NMDA receptor modulators and uses thereof
    Patent number: 9593145
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: March 14, 2017
    Assignee: Northwestern University
    Inventors: Joseph R. Moskal, M. Amin Khan
  • METHODS OF TREATING ALZHEIMER'S DISEASE, HUNTINGTON'S DISEASE, AUTISM, OR OTHER DISORDERS
    Publication number: 20170049845
    Abstract: The disclosure relates, at least in part, to methods of treating autism in a patient in need thereof by administering an effective amount of a disclosed compound, e.g., a NMDA receptor glycine site partial agonist.
    Type: Application
    Filed: April 14, 2016
    Publication date: February 23, 2017
    Inventor: Joseph R. Moskal
  • SECONDARY STRUCTURE STABILIZED NMDA RECEPTOR MODULATORS AND USES THEREOF
    Publication number: 20160115197
    Abstract: Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain.
    Type: Application
    Filed: May 14, 2015
    Publication date: April 28, 2016
    Inventors: Joseph R. Moskal, M. Amin Khan
  • METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES
    Publication number: 20160002292
    Abstract: The invention relates to methods for treating depression, anxiety, and other related diseases by administering a peptide NMDAR partial agonist.
    Type: Application
    Filed: February 6, 2015
    Publication date: January 7, 2016
    Inventor: Joseph R. Moskal