Patents by Inventor Joseph Schoepfer

Joseph Schoepfer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20130012476
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Inventors: Qiang DING, Nathanael Schiander GRAY, Bing LI, Yi LIU, Taebo SIM, Tetsuo UNO, Guobao ZHANG, Carole Pissot Soldermann, Werner BREITENSTEIN, Guido BOLD, Giorgio CARAVATTI, Pascal FURET, Vito GUAGNANO, Marc LANG, Paul W. MANLEY, Joseph SCHOEPFER, Carsten SPANKA
  • Publication number: 20130012704
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Inventors: Qiang DING, Nathanael Schiander GRAY, Bing LI, Yi LIU, Taebo SIM, Tetsuo UNO, Guobao ZHANG, Carole Pissot Soldermann, Werner BREITENSTEIN, Guido BOLD, Giorgio CARAVATTI, Pascal FURET, Vito GUAGNANO, Marc LANG, Paul W. MANLEY, Joseph SCHOEPFER, Carsten SPANKA
  • Publication number: 20120214813
    Abstract: The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate or a solvate for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multicentric Castleman disease and/or psioriasis.
    Type: Application
    Filed: May 2, 2012
    Publication date: August 23, 2012
    Applicant: NOVARTIS AG
    Inventors: Patrick Chene, Carlos Garcia-Echeverria, Michael Rugaard Jensen, Cornelia Quadt, Thomas Radimerski, Joseph Schoepfer
  • Patent number: 8217045
    Abstract: The invention relates to naphthalene carboxylic acid and isoquinoline carboxylic acid amides, and related compounds of formula I and their uses as pharmaceuticals.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: July 10, 2012
    Assignee: Novartis AG
    Inventors: Paul W. Manley, Joseph Schoepfer
  • Publication number: 20120083496
    Abstract: The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate or a solvate for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multicentric Castleman disease and/or psioriasis.
    Type: Application
    Filed: December 8, 2011
    Publication date: April 5, 2012
    Applicant: NOVARTIS AG
    Inventors: Patrick CHENE, Carlos GARCIA-ECHEVERRIA, Michael Rugaard JENSEN, Cornelia QUADT, Thomas RADIMERSKI, Joseph SCHOEPFER
  • Publication number: 20110039831
    Abstract: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
    Type: Application
    Filed: August 3, 2010
    Publication date: February 17, 2011
    Inventors: Pascal Furet, Clive McCarthy, Joseph Schoepfer, Stefan Stutz
  • Publication number: 20100311729
    Abstract: The present invention relates to compounds are of the formula I, processes for the preparation thereof, more generally these compounds for use in the treatment of the human or animal body, in the treatment of an inflammatory or obstructive airway disease, disorders commonly occurring in connection with transplantation, or a proliferative disease, which disease responds to an inhibition of kinases of the PI3-kinase-related protein kinase family.
    Type: Application
    Filed: May 9, 2008
    Publication date: December 9, 2010
    Inventors: Hans-Georg Capraro, Patricia Imbach, Giorgio Caravatti, Pascal Furet, Jiong Lan, Sabrina Pecchi, Joseph Schoepfer
  • Patent number: 7795288
    Abstract: The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubstituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; or a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the Flt-3 kinase.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: September 14, 2010
    Assignee: Novartis AG
    Inventors: Guido Bold, Andreas Floersheimer, Pascal Furet, Vito Guagnano, Keiichi Masuya, Andrea Vaupel, Joseph Schoepfer
  • Publication number: 20100210650
    Abstract: The use of 5-(2,4-Dihydroxy-5-isopropyl-phenyl)-4-(4-morpholin-4-ylmethyl-phenyl)-isoxazole-3-carboxylic acid ethylamide or a tautomer thereof or a pharmaceutically acceptable salt or a hydrate or a solvate for the treatment of cancer of the bladder, the colon, the liver, the lung, the breast, the vagina, the ovaries, the pancreas, the kidney, the stomach, the gastrointestinal tract, the prostate, the head and neck, the peritoneal cavity, the thyroid, the bone, the brain, the central nervous system and/or the blood and/or for the treatment of myelodysplastic syndrome, systemic mastocytosis, von Hippel-Lindau syndrome, multicentric Castleman disease and/or psioriasis.
    Type: Application
    Filed: October 10, 2008
    Publication date: August 19, 2010
    Applicant: NOVARTIS AG
    Inventors: Patrick Chene, Carlos Garcia-Echeverria, Michael Rugaard Jensen, Cornelia Quadt, Thomas Radimerski, Joseph Schoepfer
  • Publication number: 20100113467
    Abstract: The invention relates to naphthalene carboxylic acid and isoquinoline carboxylic acid amides, and related compounds of formula I and their uses as pharmaceuticals.
    Type: Application
    Filed: April 17, 2008
    Publication date: May 6, 2010
    Inventors: Paul W. Manley, Joseph Schoepfer
  • Publication number: 20090264406
    Abstract: The invention relates to compounds of formula (I) and salts thereof wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for the treatment of the human or animal body, in particular with regard to C-Met tyrosine kinase mediated disease; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner; processes for the preparation of a compound of formula (I).
    Type: Application
    Filed: March 2, 2009
    Publication date: October 22, 2009
    Inventors: Pascal Furet, Clive McCarthy, Joseph Schoepfer, Carsten Spanka, Melanie Stang, Frederic Stauffer
  • Publication number: 20090137804
    Abstract: The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.
    Type: Application
    Filed: June 23, 2005
    Publication date: May 28, 2009
    Inventors: Qiang Ding, Nathanael Schiander Gray, Bing Li, Yi Liu, Taebo Sim, Tetsuo Uno, Guobao Zhang, Carole Pissot Soldermann, Werner Breitenstein, Guido Bold, Giorgio Caravatti, Pascal Furet, Vito Guagnano, Marc Lang, Paul W. Manley, Joseph Schoepfer, Carsten Spanka
  • Publication number: 20090069341
    Abstract: The invention relates to the use of benzoimidazolone compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising benzoimidazolone compounds, novel benzoimidazolone compounds, and a process for the preparation of the novel benzoimidazolone compounds.
    Type: Application
    Filed: July 26, 2005
    Publication date: March 12, 2009
    Inventors: Patrick Chene, Andreas Floersheimer, Pascal Furet, Joseph Schoepfer
  • Publication number: 20090039811
    Abstract: The invention relates to the use of 1H-indazol-6-ol compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 1H-indazol-6-ol compounds, novel 1H-indazol-6-ol compounds, and a process for the preparation of the novel 1H-indazol-6-ol compounds.
    Type: Application
    Filed: July 26, 2005
    Publication date: February 12, 2009
    Inventors: Patrick Chene, Andreas Floersheimer, Pascal Furet, Joseph Schoepfer
  • Publication number: 20080311038
    Abstract: The present invention relates to novel radicicol derivatives of the formula I, in which R is R?, (CH2)nCOOR? or (CH2)nCONHR?, wherein R? is 11CH3, [3H]3C, [3H]2HC, [3H]H2C or (CH2)nHal, wherein Hal is 123I, 125I, 131I, I, 75Br, 76Br, 77Br, 82Br, Br, 18F or F, or R? is (CH2)n-1[3H]HCHal or (CH2)n-1[3H]2CHal, wherein Hal is I, Br or F, and n is, each independently, 1, 2, 3 or 4, in free form or in salt form, to their preparation, to their use as radiotracers/markers and to compositions containing them.
    Type: Application
    Filed: January 2, 2007
    Publication date: December 18, 2008
    Inventors: Yves Auberson, Mats Bergstroem, Emmanuelle Briard, Patrick Chene, Laurent Martarello, Joseph Schoepfer
  • Publication number: 20070249639
    Abstract: The invention relates to the use of 9H-purine-2,6-diamine compounds and salts thereof in the treatment of proliferative diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, pharmaceutical preparations comprising 9H-purine-2,6-diamine compounds, novel 9H-purine-2,6-diamine compounds, and a process for the preparation of the novel 9H-purine-2,6-diamine compounds.
    Type: Application
    Filed: April 4, 2005
    Publication date: October 25, 2007
    Inventors: Rolf Baenteli, Patrick Chene, Stephen Collingwood, Pascal Furet, Peter Meier, Joseph Schoepfer
  • Publication number: 20070167449
    Abstract: The invention relates to thiazole and pyrazole derivatives of formula (I) wherein Q is S and X is C, or Q is CH and X is N; R1 is unsubstituted or substituted phenyl; and R2 is unsubstituted or substituted aryl or heteroaryl; or a salt of the said compounds, and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour disease, in particular such diseases which respond to an inhibition of the Flt-3 kinase.
    Type: Application
    Filed: November 12, 2004
    Publication date: July 19, 2007
    Inventors: Guido Bold, Andreas Floersheimer, Pascal Furet, Vito Guagnano, Keiichi Masuya, Andrea Vaupel, Joseph Schoepfer
  • Patent number: 7189729
    Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, BCR-Abl, EGF-R, c-erbB2 kinase (HER-2), CHK2, FGFR3, p70S6K, PKC, PDGF-R, p38, TGF?, KDR, c-Kit, b-RAF, c-RAF, FLT1 and/or FLT4 kinases.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: March 13, 2007
    Assignee: IRM LLC
    Inventors: Greg Chopiuk, Pascal Furet, Nathanael Schiander Gray, Patricia Imbach, Yi Liu, Joseph Schoepfer, Ruo Steensma
  • Publication number: 20060211747
    Abstract: The present invention relates to methods of searching/screening for compounds which inhibit the activity of the ubiquitin conjugating enzyme Cdc34 in a zinc-mediated manner, to compounds obtainable by such a method, to a method of treating mammalian subjects with such compounds, to pharmaceutical compositions containing such compounds, to the use of such compounds for the treatment of diseases which respond to an inhibition of the activity of Cdc34 such as proliferative diseases, especially tumor diseases, and to the use of such compounds for the preparation of such pharmaceutical compositions for the treatment of such diseases.
    Type: Application
    Filed: September 14, 2005
    Publication date: September 21, 2006
    Inventors: Pascal Furet, Francesco Hofmann, Edgar Jacoby, Joseph Schoepfer
  • Publication number: 20050222171
    Abstract: The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.
    Type: Application
    Filed: January 20, 2005
    Publication date: October 6, 2005
    Inventors: Guido Bold, Andreas Floersheimer, Pascal Furet, Patricia Imbach, Keiichi Masuya, Joseph Schoepfer