Abstract: Aspects of the present disclosure include sample analysis methods and systems. According to certain embodiments, provided are methods of analyzing samples in an automated sample analysis system. The methods include introducing samples and sample preparation cartridges into the system, isolating and purifying an analyte (e.g., nucleic acids and/or proteins) present in the samples at a sample preparation station, and performing analyte detection assays in assay mixtures that include the purified analyte. Also provided are automated sample analysis systems that find use, e.g., in performing the methods of the present disclosure. In certain aspects, the methods and systems provide for continuous operator access during replenishment or removal of one or any combination of samples, bulk fluids, reagents, commodities, waste, and/or the like.

Abstract: A clipping device includes a clip including a capsule and a pair of clip arms, proximal ends of which are slidably received within the channel to move the clip arms between an open configuration and a closed configuration. Each of the pair of clip arms includes an elongated opening extending through the proximal ends thereof. A connector includes a central portion received between the proximal ends of the clip arms and a pin extending from the central portion receivable within the opening of each of the clip arms, the connector movable from an unlocked configuration, in which the pin is received within a distal portion of the elongated opening, to a locked configuration, in which the pin is received within a proximal portion of the elongated opening, when a predetermined force is applied thereto.

Abstract: Aspects of the present disclosure involve a CDN utilizing a Direct Server Return (DSR) request command to create a tunnel from one content server to another content server of the CDN. Through the DSR tunnel, a request for content may be served from a content server that is more advantageous for the CDN for any number of reasons, such as from a content server that is logically closer to the content server. In determining when a DSR tunnel is created to provide the content, the CDN may access a database storing various information concerning the CDN, such as the location of egress gateways of the CDN in relation to one or more content servers, connecting network location information, the capabilities of one or more content servers, and/or load information of available content servers.

Abstract: An MFD is disclosed. For example, the MFD includes a printhead to dispense print material, an enhancement printhead to dispense an enhancement printing fluid, a processor and a non-transitory computer-readable medium storing a plurality of instructions. The instructions when executed by the processor cause the processor to perform operations that include determining that an automated enhancement feature was selected, analyzing each pixel of an image to be printed to determine one or more pixels that are to receive the enhancement printing fluid, controlling the printhead to print the image, and controlling the enhancement printhead to dispense the enhancement printing fluid on the one or more pixels that are to receive the enhancement printing fluid.

Abstract: Image processing device security is provided herein. A method can include assembling, by a first system comprising a processor using a first virtual machine enabled via the first system, raw input data captured by an image capture device from an input image, resulting in assembled input data; generating, by the first system using a second virtual machine that is enabled via the first system and distinct from the first virtual machine, an output image from the assembled input data; reading, by the first system in response to the generating, the output image; and preventing, by the first system, a second system, distinct from the first system, from accessing the output image in response to the reading resulting in execution of unauthorized instructions at the first system.

Abstract: Implementations described and claimed herein provide an underwater vehicle includes a vehicle body having a frame enclosed by a fairing. The vehicle body extends between a proximal end and a distal end and defining an interior. A nose is disposed at the proximal end of the vehicle body. The nose has a tow system configured to move between a tow position and a stow position. A propulsion system is disposed at the distal end of the vehicle body. The propulsion system includes a plurality of control fins and a thruster. A power distribution system is housed in the interior of the vehicle body. The power distribution system includes a first power system housed in a first pressure vessel and a second power system housed in a second pressure vessel. The first pressure vessel is isolated from the second pressure vessel.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: A switching regulator includes a low-side switching transistor, a snubber transistor, a first pull-down transistor, and a second pull-down transistor. The low-side switching transistor includes a first current terminal and a second current terminal. The first current terminal is coupled to a switching node. The second current terminal is coupled to a ground terminal. The snubber transistor includes a first current terminal, a second current terminal, and a control terminal. The first current terminal is coupled to the switching node. The second current terminal is coupled to the ground terminal. The first pull-down transistor is coupled between the control terminal of the snubber transistor and the ground terminal. The second pull-down transistor is coupled between the control terminal of the snubber transistor and the ground terminal.

Abstract: A through the road (TTR) hybridization strategy is proposed to facilitate introduction of hybrid electric vehicle technology in a significant portion of current and expected trucking fleets. In some cases, the technologies can be retrofitted onto an existing vehicle (e.g., a trailer, a tractor-trailer configuration, etc.). In some cases, the technologies can be built into new vehicles. In some cases, one vehicle may be built or retrofitted to operate in tandem with another and provide the hybridization benefits contemplated herein. By supplementing motive forces delivered through a primary drivetrain and fuel-fed engine with supplemental torque delivered at one or more electrically-powered drive axles, improvements in overall fuel efficiency and performance may be delivered, typically without significant redesign of existing components and systems that have been proven in the trucking industry.

Abstract: An air-to-air heat recovery core, comprising: a core assembly having parallel first and second channels that are open to first and second sides of the core assembly, respectively, the first and second channels interleaved, and each first channel sharing a wall with an adjacent second channel; first and second sealants formed along opposite first and second edges, respectively, of the core assembly perpendicular to a running direction of the first and second channels, the first and second sealants respectively blocking first and second ends of the channels; and first and second panels secured to first and second sides of the core assembly, respectively, the first and second panels blocking a middle portion of the first and second channels, respectively, such that air can enter and leave the first and second channels via the first and second end portions of the first and second channels but not via the middle portions.

Abstract: The invention is a bike rack with a rotating platform mechanism to ease the loading and unloading of bicycles. The present disclosure is directed to a bike rack coupled to a rotating platform. The rotating platform is a mechanism that allows the rack to perform its dual functions. The rotating platform comprises a series of plates. One plate is a faceplate, and the remainder are tilt plates. A pin is coupled with the faceplate. The tilt plate has a slot with two stops. One stop defines the driving position, and the second defines the tilt position. The pin passes through the tilt slot and retains the platform in the driving or tilt positions. Optionally a third tilt plate locks the platform in either position. Optionally, the faceplate and tilt plate(s) are coupled to a pivot that is off-center from the centerline of the platform.

Abstract: A recommendation system includes a content similarity analyzer configured to determine a first set of content item identifiers similar to a set of viewed content items based on respective similarity scores and add them to a first list. A similar user content extraction module identifies a set of similar user identifiers from a user similarity database; obtains, based on respective viewing histories of the set, a second set of content item identifiers; and adds them to the first list. The recommendation system includes a content filter configured to select a subset of content item identifiers from the first list based on the corresponding similarity scores between content item identifiers of the first list and a viewing history. The content filter is configured to transmit the subset of content item identifiers for display of the corresponding content items via a web portal on a user interface of a first user device.

Abstract: A vehicular control system includes a plurality of sensors disposed at a vehicle so as to have a combined field of sensing forward, rearward and sideward of the vehicle. Data captured by the sensors as the vehicle moves along a road is processed at a control for detecting objects present exterior the vehicle. The control designates a plurality of locations within the fields of sensing. As the vehicle moves along the road, the control increases a value for each designated location when an object is detected at that designated location, and decreases the value for each designated location when an object is not detected at that designated location, and generates an object map based on values for the designated locations. The greater the value for a particular designated location, the greater the probability an object is present at that particular designated location.

Abstract: System and methods are described for directly measuring mechanical properties of a sample while concurrently imaging the sample using a scanning beam microscope (e.g., a scanning electron microscope (SEM)).

Abstract: A solid cleansing product including at least a first surfactant and a second surfactant present in a combined surfactant weight amount; at least a first buffering agent and a second buffering agent a present in a combined buffering agent weight amount; and magnesium sulfate; where the combined buffering agent weight amount is greater than the combined surfactant weight amount.

Abstract: The present disclosure relates to semiconductor structures and, more particularly, to photodetectors with buried airgap mirror reflectors. The structure includes a photodetector and at least one airgap in a substrate under the photodetector.

Abstract: A glass composition includes: greater than or equal to 55 mol % and less than or equal to 70 mol % SiO2; greater than or equal to 14 mol % and less than or equal to 25 mol % Al2O3; greater than or equal to 0 mol % B2O3; greater than or equal to 0 mol % P2O5; greater than or equal to 0 mol % and less than or equal to 10 mol % Li2O; greater than or equal to 6.5 mol % and less than or equal to 20 mol % Na2O; greater than or equal to 0 mol % K2O; greater than or equal to 0.1 mol % and less than or equal to 4.5 mol % MgO; greater than or equal to 0 mol % CaO; and greater than or equal to 0 mol % SrO. The sum of Li2O, Na2O, and K2O in the glass composition may be greater than or equal to 6.5 mol % and less than or equal to 22 mol %. The glass composition may satisfy the relationship Al2O3*(2.94)+B2O3*(?0.58)+P2O5*(?3.87)+Li2O*(5.01)+Na2O*(1.89)+K2O*(?2.03) is greater than 100.

Abstract: A power outlet control device includes at least one electrical outlet and a processing circuit comprising a processor and memory storing instructions that, when executed by the processor, cause the processor to perform operations. The operations include monitoring external power supplied to the power outlet control device, detecting one or more powerline events based on the external power supplied to the power outlet control device, and automatically controlling an amount of power supplied to the at least one electrical outlet based on the one or more powerline events.