Patents by Inventor JOSEPHINE KAHN

JOSEPHINE KAHN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING CHEMOTHERAPY RESISTANT CANCER
    Publication number: 20220362228
    Abstract: The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.
    Type: Application
    Filed: March 7, 2022
    Publication date: November 17, 2022
    Applicant: The Brigham And Women's Hospital, Inc.
    Inventors: Josephine KAHN, Siddhartha JAISWAL, Benjamin EBERT
  • Compositions and methods for treating chemotherapy resistant cancer
    Patent number: 11304938
    Abstract: The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: April 19, 2022
    Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Josephine Kahn, Siddhartha Jaiswal, Benjamin Ebert
  • COMPOSITIONS AND METHODS FOR TREATING CHEMOTHERAPY RESISTANT CANCER
    Publication number: 20210137902
    Abstract: The present invention features methods for increasing sensitivity and/or reversing resistance to chemotherapy, methods for treating or preventing a cancer in a subject, methods for treating clonal hematopoiesis of indeterminate potential in a subject, and methods of identifying resistance or sensitivity to chemotherapy in a subject. In some embodiments, the methods contain the step of administering an agent that inhibits the expression or activity of a Protein phosphatase 1D (PPM1D) polypeptide or polynucleotide. The present invention also features compositions for increasing sensitivity and/or reversing resistance to chemotherapy.
    Type: Application
    Filed: March 10, 2017
    Publication date: May 13, 2021
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: JOSEPHINE KAHN, SIDDHARTHA JAISWAL, BENJAMIN EBERT