Patents by Inventor Josephine Lee
Josephine Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230340565Abstract: The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.Type: ApplicationFiled: January 17, 2023Publication date: October 26, 2023Inventors: Zahra Kamila BELHOCINE, Josephine Lee, Francesca MESCHI, Luz MONTESCLAROS, Katherine PFEIFFER, Andrew D. PRICE, Jerald SAPIDA, David SUKOVICH, Tobias Daniel WHEELER, Yifeng YIN
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Patent number: 11767547Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: October 3, 2019Date of Patent: September 26, 2023Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 11649487Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.Type: GrantFiled: August 6, 2020Date of Patent: May 16, 2023Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 11603558Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: November 14, 2018Date of Patent: March 14, 2023Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Patent number: 11584954Abstract: The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.Type: GrantFiled: April 22, 2020Date of Patent: February 21, 2023Assignee: 10X GENOMICS, INC.Inventors: Zahra Kamila Belhocine, Josephine Lee, Francesca Meschi, Luz Montesclaros, Katherine Pfeiffer, Andrew D. Price, Jerald Sapida, David Sukovich, Tobias Daniel Wheeler, Yifeng Yin
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Patent number: 11254960Abstract: Methods and compositions for the amplification of nucleic acids are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases, ligases, and primers.Type: GrantFiled: September 8, 2015Date of Patent: February 22, 2022Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Pranav Patel, Josephine Lee, Aaron Richardson, Scott Tabakman
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Publication number: 20210332400Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: ApplicationFiled: October 3, 2019Publication date: October 28, 2021Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Publication number: 20210147910Abstract: Improved methods for amplifying target nucleic acid sequences are provided by 1) first amplifying the number of copies of target nucleic acid sequences in a sample by a first nucleic acid amplification method, and then 2) applying a second nucleic amplification method to the amplified sample, or aliquot thereof, further amplifying the number of copies of target sequences. In embodiments, a first nucleic acid amplification method is a thermocycling method, and a second nucleic acid amplification method is an isothermal method.Type: ApplicationFiled: October 29, 2020Publication date: May 20, 2021Inventors: Pranav Patel, Indira Wu, Aaron Richardson, Zahra Kamila Belhocine, Josephine Lee, Scott Tabakman
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Publication number: 20210115415Abstract: Disclosed herein, are compositions, methods, and kits comprising engineered reverse transcription enzymes that exhibit several desired properties such as thermal stability, processive reverse transcription, non-templated base addition, and template switching ability. The engineered reverse transcription enzymes described herein demonstrate unexpectedly higher resistance to cell lysate inhibition, greater ability to capture full-length mRNA transcripts, and demonstrate improved results in small reaction volumes as compared to other engineered reverse transcription enzymes.Type: ApplicationFiled: December 7, 2020Publication date: April 22, 2021Applicant: 10X Genomics, Inc.Inventors: Josephine Lee, Samuel Marrs, Geoffrey McDermott, Francesca Meschi, Luz Montesclaros, Katherine Pfeiffer, Joseph Francis Shuga, Jessica Michele Terry, Solongo B. Ziraldo
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Publication number: 20210024987Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.Type: ApplicationFiled: August 6, 2020Publication date: January 28, 2021Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Publication number: 20200354771Abstract: The present disclosure provides methods and systems for sample preparation and/or analysis. Samples may be cells, or may be derived from one or more cells. Sample preparation may comprise conducting one or more reactions on a target. Such reactions may be conducted in one or more partitions. One or more reactions may be performed in one or more successive operations.Type: ApplicationFiled: April 22, 2020Publication date: November 12, 2020Inventors: Zahra Kamila Belhocine, Josephine Lee, Francesca Meschi, Luz Montesclaros, Katherine Pfeiffer, Andrew D. Price, Jerald Sapida, David Sukovich, Tobias Daniel Wheeler, Yifeng Yin
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Patent number: 10822648Abstract: Improved methods for amplifying target nucleic acid sequences are provided by 1) first amplifying the number of copies of target nucleic acid sequences in a sample by a first nucleic acid amplification method, and then 2) applying a second nucleic amplification method to the amplified sample, or aliquot thereof, further amplifying the number of copies of target sequences. In embodiments, a first nucleic acid amplification method is a thermocycling method, and a second nucleic acid amplification method is an isothermal method.Type: GrantFiled: July 31, 2017Date of Patent: November 3, 2020Assignee: Labrador Diagnostics LLCInventors: Pranav Patel, Indira Wu, Aaron Richardson, Zahra Kamila Belhocine, Josephine Lee, Scott Tabakman
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Publication number: 20200263232Abstract: Methods and compositions to minimize barcode exchange during the preparation of barcoded next-generation sequencing libraries prepared from a single cell. The methods utilize oligonucleotides containing a 3?-terminated blocking group or sequences that prevent amplification or extension.Type: ApplicationFiled: August 2, 2019Publication date: August 20, 2020Inventors: Jason Bell, Josephine Lee, Corey Nemec, Francesca Meschi
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Patent number: 10745745Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such nucleic acid polymerases and primers.Type: GrantFiled: July 6, 2017Date of Patent: August 18, 2020Assignee: Labrador Diagnostics LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Publication number: 20200013488Abstract: Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.Type: ApplicationFiled: April 12, 2019Publication date: January 9, 2020Inventors: Clarissa Lui, Elizabeth A. Holmes, Pranav Patel, Scott Tabakman, Zahra Kamila Belhocine, Aaron Richardson, Josephine Lee
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Patent number: 10450595Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: October 12, 2015Date of Patent: October 22, 2019Assignee: Theranos IP Company, LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Publication number: 20190203278Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: ApplicationFiled: November 14, 2018Publication date: July 4, 2019Inventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman
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Publication number: 20190174874Abstract: A system for automatic fitting of athletic footwear comprises a measuring device of foot data that scans a user's foot at least at two directions; a user interface that questions the user, and/or observes the user's foot; an analyzing device that analyzes the foot data measured by the measuring device; and a knowledgebase database that stores data for footwear determination provided by the analyzing device. The analyzing device comprises a case based reasoning system that goes through adaptation process in a similarity matrix of previous cases which are retrieved from the knowledgebase database, and an expert system that operates a function that determines a footwear based on the data provided by the measuring device and the user interface.Type: ApplicationFiled: December 28, 2015Publication date: June 13, 2019Inventors: Albert Lee, Hae Kyung Lee, Josephine Lee
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Patent number: 10283217Abstract: Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.Type: GrantFiled: July 1, 2015Date of Patent: May 7, 2019Assignee: Theranos IP Company, LLCInventors: Clarissa Lui, Elizabeth A. Holmes, Pranav Patel, Scott Tabakman, Kamila Belhocine, Aaron Richardson, Josephine Lee
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Patent number: 10131939Abstract: Methods and compositions for the amplification of nucleic acids and generation of concatemers are disclosed. Amplification methods provided herein may be performed under isothermal conditions. Methods and compositions may include reagents such as nucleic acid polymerases and primers.Type: GrantFiled: September 10, 2015Date of Patent: November 20, 2018Assignee: Theranos IP Company, LLCInventors: Kamila Belhocine, Josephine Lee, Pranav Patel, Aaron Richardson, Scott Tabakman