Abstract: The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

Abstract: A robotic surgical system for treating a patient is disclosed including a surgical tool movable relative to the patient and a user input device configured to remotely control the surgical tool. The surgical tool includes a shaft and an end effector. The user input device includes a base and a controller movable to effect a first control motion a second control motion. The controller includes a first accessibility mode and a second accessibility mode. The robotic surgical system further includes a control circuit configured to receive a motion control signal from the user input device, determine a controller accessibility mode, permit the first control motion in response to the motion control signal in the first accessibility mode and in the second accessibility mode and permit the second control motion in response to the motion control signal in the second accessibility mode but not the first accessibility mode.

Abstract: A surgical suturing tracking system is disclosed. The surgical suturing tracking system is configured to detect and guide a suturing needle during a surgical suturing procedure. The surgical suturing track system comprises a control circuit configured to predict a path of a needle suturing stroke after receiving an input from a clinician, detect an embedded tissue structure, and assess proximity of the predicted path and the detected embedded tissue structure.

Abstract: A surgical visualization system is disclosed. The surgical visualization system includes a control circuit communicatively coupled to a straight line laser source, a structured light emitter, and an image sensor; and a memory communicatively coupled to the control circuit. The memory stores instructions which, when executed, cause the control circuit to control the straight line laser source to project a straight laser line reference; control the structured light source to emit a structured light pattern onto a surface of an element of a surgical device; control the image sensor to detect the projected straight laser line and structured light reflected from the surface of the element of the surgical device; and determine a position of the element of the surgical device relative to the projected straight laser line reference.

Abstract: A surgical instrument includes a drive housing, a spline, a carriage, an elongate shaft assembly, an end effector, and an activating mechanism. The spline includes a drive gear rotatable via the spline. The shaft assembly extends along a longitudinal axis from the carriage. The shaft assembly includes a wrist disposed between the end effector and a distal end of the shaft assembly. The activating mechanism includes a barrel cam extending along a rotational axis and having a first cam profile radially extending about the rotational axis. The barrel cam is operatively coupled to the drive gear such that rotation of the drive gear is configured to actuate the activating mechanism to move at least a portion of the end effector or the shaft assembly. The first cam profile defines a lock zone configured to selectively lock movement of the portion of the end effector or the shaft assembly.

Abstract: A surgical suturing tracking system is disclosed. The surgical suturing tracking system is configured to detect and guide a suturing needle during a surgical suturing procedure. The surgical suturing track system comprises a control circuit configured to predict a path of a needle suturing stroke after receiving an input from a clinician, detect an embedded tissue structure, and assess proximity of the predicted path and the detected embedded tissue structure.

Abstract: A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

Abstract: A surgical access assembly comprises a trocar and a surgical instrument. The trocar comprises a housing and an access tube extending distally from the housing. The housing comprises a hollow light emitter. The housing and the access tube define a lumen extending through the housing and the access tube. The hollow light emitter is configured to project light in the lumen. The surgical instrument comprises an end effector and a shaft extending proximally from the end effector. The shaft comprises an optical receiver positioned within reach of the light from the hollow light emitter. The shaft further comprises a light guide extending from the optical receiver along at least a portion of the shaft toward the end effector.

Abstract: A sphincter augmentation device includes a plurality of interlinked bodies and a pair of device ends configured to releasably couple together to secure the bodies in a loop formation sized to fit around an internal anatomical passageway of a patient. The device further includes a plurality of resilient members, with each resilient member extending between an adjacent pair of the bodies. The resilient members are configured to elastically deform to permit the device to transition between a radially contracted state and a radially expanded state. The resilient members bias the device toward the radially contracted state in which the device exerts an inwardly directed force on the anatomical passageway to selectively limit passage of fluids therethrough. The device further includes an expansion limiting member that extends between and is slidably received by an adjacent pair of the bodies, and is configured to limit radial expansion of the device.

Abstract: A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

Abstract: A sphincter augmentation device includes a plurality of interlinked bodies and a pair of device ends configured to releasably couple together to secure the bodies in a loop formation sized to fit around an internal anatomical passageway of a patient. The device further includes a plurality of resilient members, with each resilient member extending between an adjacent pair of the bodies. The resilient members are configured to elastically deform to permit the device to transition between a radially contracted state and a radially expanded state. The resilient members bias the device toward the radially contracted state in which the device exerts an inwardly directed force on the anatomical passageway to selectively limit passage of fluids therethrough. The device further includes an expansion limiting member that extends between and is slidably received by an adjacent pair of the bodies, and is configured to limit radial expansion of the device.

Abstract: A surgical access assembly comprises a trocar and a surgical instrument. The trocar comprises a housing and an access tube extending distally from the housing. The housing comprises a hollow light emitter. The housing and the access tube define a lumen extending through the housing and the access tube. The hollow light emitter is configured to project light in the lumen. The surgical instrument comprises an end effector and a shaft extending proximally from the end effector. The shaft comprises an optical receiver positioned within reach of the light from the hollow light emitter. The shaft further comprises a light guide extending from the optical receiver along at least a portion of the shaft toward the end effector.

Abstract: A method includes advancing an end effector of a surgical tool to a surgical site, setting a desired force vector to be assumed on the end effector during actuation of the end effector, engaging tissue at the surgical site with the end effector and calculating a force vector assumed on the end effector, and maneuvering the end effector to obtain the desired force vector.

Abstract: A method includes advancing an end effector of a surgical tool to a surgical site, the surgical tool being pivotably mounted to a robotic arm at a tool driver, engaging tissue at the surgical site with the end effector, calculating a force vector assumed on the end effector by engaging the tissue, optimizing the force vector to obtain an optimized force vector, and actuating the end effector after applying the optimized force vector on the end effector.

Abstract: A robotic surgical system for treating a patient is disclosed including a surgical tool movable relative to the patient and a user input device configured to remotely control the surgical tool. The surgical tool includes a shaft and an end effector. The user input device includes a base and a controller movable to effect a first control motion a second control motion. The controller includes a first accessibility mode and a second accessibility mode. The robotic surgical system further includes a control circuit configured to receive a motion control signal from the user input device, determine a controller accessibility mode, permit the first control motion in response to the motion control signal in the first accessibility mode and in the second accessibility mode and permit the second control motion in response to the motion control signal in the second accessibility mode but not the first accessibility mode.

Abstract: A sphincter augmentation device includes a plurality of interlinked bodies and a pair of device ends configured to releasably couple together to secure the bodies in a loop formation sized to fit around an internal anatomical passageway of a patient. The device further includes a plurality of resilient members, with each resilient member extending between an adjacent pair of the bodies. The resilient members are configured to elastically deform to permit the device to transition between a radially contracted state and a radially expanded state. The resilient members bias the device toward the radially contracted state in which the device exerts an inwardly directed force on the anatomical passageway to selectively limit passage of fluids therethrough. The device further includes an expansion limiting member that extends between and is slidably received by an adjacent pair of the bodies, and is configured to limit radial expansion of the device.

Abstract: A method includes advancing an end effector of a surgical tool to a surgical site, setting a desired force vector to be assumed on the end effector during actuation of the end effector, engaging tissue at the surgical site with the end effector and calculating a force vector assumed on the end effector, and maneuvering the end effector to obtain the desired force vector.

Abstract: A method includes advancing an end effector of a surgical tool to a surgical site, the surgical tool being pivotably mounted to a robotic arm at a tool driver, engaging tissue at the surgical site with the end effector, calculating a force vector assumed on the end effector by engaging the tissue, optimizing the force vector to obtain an optimized force vector, and actuating the end effector after applying the optimized force vector on the end effector.

Abstract: A surgical visualization system is disclosed. The surgical visualization system includes a control circuit communicatively coupled to a straight line laser source, a structured light emitter, and an image sensor; and a memory communicatively coupled to the control circuit. The memory stores instructions which, when executed, cause the control circuit to control the straight line laser source to project a straight laser line reference; control the structured light source to emit a structured light pattern onto a surface of an element of a surgical device; control the image sensor to detect the projected straight laser line and structured light reflected from the surface of the element of the surgical device; and determine a position of the element of the surgical device relative to the projected straight laser line reference.

Abstract: A surgical access assembly comprises a trocar and a surgical instrument. The trocar comprises a housing and an access tube extending distally from the housing. The housing comprises a hollow light emitter. The housing and the access tube define a lumen extending through the housing and the access tube. The hollow light emitter is configured to project light in the lumen. The surgical instrument comprises an end effector and a shaft extending proximally from the end effector. The shaft comprises an optical receiver positioned within reach of the light from the hollow light emitter. The shaft further comprises a light guide extending from the optical receiver along at least a portion of the shaft toward the end effector.