Abstract: Described herein are methods and devices for monitoring or modulating an immune system in a subject with cancer, and methods and devices for treating a cancer in a subject. The implanted device can electrically stimulate the splenic nerve of the subject, which can modulate the inflammatory system (for example, by increasing or decreasing the blood level of one or more pro-inflammatory cytokines and/or anti-inflammatory cytokines to increase or decrease inflammation in the subject) and/or activate or increase circulation of one or more immune cells (such as natural killer cells and/or cytotoxic T-cells), for the treatment of cancer. The implanted medical device includes two or more electrodes configured to electrically stimulate the splenic nerve, and may further include an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device.

Abstract: Described herein are methods for monitoring or modulating an immune system in a subject; treating, reducing or monitoring inflammation; monitoring blood pressure; treating hypertension; or administering or adjusting a therapy for inflammation or hypertension in a patient by electrically stimulating the splenic nerve or detecting splenic nerve activity using an implanted medical device. Also described herein are implantable medical devices for performing such methods. The implanted medical device includes an ultrasonic transducer configured to receive ultrasonic waves and convert energy from the ultrasonic waves into an electrical energy that powers the device, two or more electrodes in electrical communication with the ultrasonic transducer that are configured to electrically stimulate a splenic nerve or detect a splenic nerve activity, and optionally a splenic nerve attachment member.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for job management in a distributed network include a prioritizer that determines a priority level for a job and inserts the job into a priority queue based on the priority level, a scheduler that, for each element in the distributed network, requests the priorities of one or more jobs scheduled for execution, evaluates, based on the priorities of the one or more jobs scheduled for execution, the priority of a particular job with respect to the element, determines, based on the priorities, that the network element is free to perform job processes, and upon determining that a network element is free, scheduling a particular job for execution, and an executor that determines that all local and remote resources required for the scheduled job are available and executes the job according to processes defined within the distributed network.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for job management in a distributed network include a prioritizer that determines a priority level for a job and inserts the job into a priority queue based on the priority level, a scheduler that, for each element in the distributed network, requests the priorities of one or more jobs scheduled for execution, evaluates, based on the priorities of the one or more jobs scheduled for execution, the priority of a particular job with respect to the element, determines, based on the priorities, that the network element is free to perform job processes, and upon determining that a network element is free, scheduling a particular job for execution, and an executor that determines that all local and remote resources required for the scheduled job are available and executes the job according to processes defined within the distributed network.