Patents by Inventor Joshua Robert Giguere

Joshua Robert Giguere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for improved oxycodone synthesis
    Patent number: 10844072
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: November 24, 2020
    Assignee: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • PROCESS FOR IMPROVED OXYCODONE SYNTHESIS
    Publication number: 20200199134
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: July 31, 2019
    Publication date: June 25, 2020
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
  • Process for improved oxycodone synthesis
    Patent number: 10428079
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: October 1, 2019
    Assignee: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics
    Patent number: 10314810
    Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: June 11, 2019
    Assignees: Trustees of Boston University, Northeastern University, Boston Medical Center Corporation
    Inventors: David H. Sherr, Michael Pollastri, Jennifer Schlezinger, Sarah Haigh Molina, Scott Schaus, Joshua Robert Giguere
  • Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics
    Patent number: 10258600
    Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: April 16, 2019
    Assignees: Trustees of Boston University, Boston Medical Center, Northeastern University
    Inventors: David H. Sherr, Michael Pollastri, Jennifer Schlezinger, Sarah Haigh Molina, Scott Schaus, Joshua Robert Giguere
  • PROCESS FOR IMPROVED OXYCODONE SYNTHESIS
    Publication number: 20190106432
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: March 30, 2018
    Publication date: April 11, 2019
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • Process for improved oxymorphone synthesis
    Patent number: 10189852
    Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Grant
    Filed: April 3, 2018
    Date of Patent: January 29, 2019
    Assignee: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
    Publication number: 20180327417
    Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: April 3, 2018
    Publication date: November 15, 2018
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • Process for improved oxymorphone synthesis
    Patent number: 9938285
    Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 10, 2018
    Assignee: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • Process for improved oxycodone synthesis
    Patent number: 9932348
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 3, 2018
    Assignee: RHODES TECHNOLOGIES
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Marcel Schleusner
  • PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
    Publication number: 20170253604
    Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: January 15, 2015
    Publication date: September 7, 2017
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
  • Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
    Patent number: 9657030
    Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: May 23, 2017
    Assignee: Rhodes Technologies
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
  • Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
    Patent number: 9624232
    Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: April 18, 2017
    Assignee: Rhodes Technologies
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
  • Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
    Patent number: 9593124
    Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
    Type: Grant
    Filed: August 4, 2015
    Date of Patent: March 14, 2017
    Assignee: Rhodes Technologies
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
  • PROCESS FOR IMPROVED OXYMORPHONE SYNTHESIS
    Publication number: 20170022209
    Abstract: Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: January 15, 2015
    Publication date: January 26, 2017
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
  • PROCESS FOR IMPROVED OXYCODONE SYNTHESIS
    Publication number: 20170022210
    Abstract: Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of trifluoroacetic acid and/or a glycol.
    Type: Application
    Filed: January 15, 2015
    Publication date: January 26, 2017
    Applicant: RHODES TECHNOLOGIES
    Inventors: Joshua Robert GIGUERE, Keith Edward MCCARTHY, Marcel SCHLEUSNER
  • Transition metal-catalyzed processes for the preparation of N-allyl compounds and use thereof
    Patent number: 9499557
    Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: November 22, 2016
    Assignee: Rhodes Technologies
    Inventors: Joshua Robert Giguere, Keith Edward McCarthy, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest
  • ARYL HYDROCARBON RECEPTOR (AhR) MODIFIERS AS NOVEL CANCER THERAPEUTICS
    Publication number: 20160175278
    Abstract: Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 23, 2016
    Applicants: Trustees of Boston University, Northeastern University, Boston Medical Center Corporation
    Inventors: David H. SHERR, Michael POLLASTRI, Jennifer SCHLEZINGER, Sarah HAIGH MOLINA, Scott SCHAUS, Joshua Robert GIGUERE
  • PROCESS FOR N-DEALKYLATION OF TERTIARY AMINES
    Publication number: 20160159813
    Abstract: The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
    Type: Application
    Filed: February 11, 2016
    Publication date: June 9, 2016
    Inventors: Joshua Robert GIGUERE, Helge Alfred REISCH, Sergio SANDOVAL, Jake Larry STYMIEST
  • Process for N-dealkylation of tertiary amines
    Patent number: 9309258
    Abstract: The present disclosure provides improved methods for N-dealkylation of tertiary amines, including methods for N-demethylation of alkaloids and opioids, in which the dealkylation reaction is carried out in a solvent comprising a tertiary alcohol. The present disclosure also provides improved processes for preparing semi-synthetic opioids that incorporate the disclosed methods for N-dealkylation of tertiary amines.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: April 12, 2016
    Assignee: Rhodes Technologies
    Inventors: Joshua Robert Giguere, Helge Alfred Reisch, Sergio Sandoval, Jake Larry Stymiest