Patents by Inventor Joshua Van Veldhuizen

Joshua Van Veldhuizen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterobicyclic metalloprotease inhibitors
    Publication number: 20070155737
    Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic ADAMTS-4 inhibiting compounds.
    Type: Application
    Filed: November 20, 2006
    Publication date: July 5, 2007
    Inventors: Brian Gallagher, Joshua Van Veldhuizen, Xinyuan Wu, Hongbo Deng, Irving Sucholeiki, Matthias Hochguertel, Harald Bluhm, Arthur Taveras
  • Heterobicyclic metalloprotease inhibitors
    Publication number: 20060293345
    Abstract: The present invention relates generally to amide group containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-13 inhibiting compounds, that exhibit an increased potency in relation to currently known MMP-13 inhibitors.
    Type: Application
    Filed: May 22, 2006
    Publication date: December 28, 2006
    Inventors: Christoph Steeneck, Christian Gege, Frank Richter, Matthias Hochguertel, Tim Feuerstein, Harald Bluhm, Irving Sucholeiki, Jurgen Boer, Xinyuan Wu, Matthias Schneider, Bert Nolte, Brian Gallagher, Joshua Van Veldhuizen, Hongbo Dong, Michael Essers, Heiko Kroth, Andrew Kiely, Timothy Powers, Arthur Taveras
  • Multicyclic bis-amide MMP inhibitors
    Publication number: 20060173183
    Abstract: The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.
    Type: Application
    Filed: December 30, 2005
    Publication date: August 3, 2006
    Inventors: Timothy Powers, Christoph Steeneck, Ralf Biesinger, Harald Bluhm, Hongbo Deng, Rory Dodd, Brian Gallagher, Christian Gege, Matthias Hochgurtel, Andrew Kiely, Frank Richter, Matthias Schneider, Irving Sucholeiki, Joshua Van Veldhuizen, Xinyuan Wu, Arthur Taveras
  • Recyclable chiral metathesis catalysts
    Patent number: 6939982
    Abstract: The present invention relates to chiral metal catalysts for stereoselective olefin metathesis reactions, which are recyclable and reusable in such metathesis reactions. The chiral metal-based metathesis catalysts of the invention comprise multidentate optically active or racemic chiral ligands that enable their use in asymmetric synthetic processes, such as for example, in ring-opening and ring-closing metathesis reactions (ROM and RCM, respectively) of alkenes. The catalysts of the invention are organometallic complexes of multivalent metals comprising one or more chiral bidentate ligands that exhibit superior reactivity and stereoselectivity properties. The present invention also provides methods of making such catalysts and methods for utilizing them in catalyzing stereoselective olefin metathesis reactions to provide asymmetric products in relatively high enantiomeric or stereoisomeric excess.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: September 6, 2005
    Assignee: The Trustees of Boston College
    Inventors: Amir H. Hoveyda, Joshua Van Veldhuizen, Steven B. Garber, Jason S. Kingsbury
  • Recyclable chiral metathesis catalysts
    Publication number: 20040019212
    Abstract: The present invention relates to chiral metal catalysts for stereoselective olefin metathesis reactions, which are recyclable and reusable in such metathesis reactions. The chiral metal-based metathesis catalysts of the invention comprise multidentate optically active or racemic chiral ligands that enable their use in asymmetric synthetic processes, such as for example, in ring-opening and ring-closing metathesis reactions (ROM and RCM, respectively) of alkenes. The catalysts of the invention are organometallic complexes of multivalent metals comprising one or more chiral bidentate ligands that exhibit superior reactivity and stereoselectivity properties. The present invention also provides methods of making such catalysts and methods for utilizing them in catalyzing stereoselective olefin metathesis reactions to provide asymmetric products in relatively high enantiomeric or stereoisomeric excess.
    Type: Application
    Filed: May 12, 2003
    Publication date: January 29, 2004
    Applicant: Trustees of Boston College
    Inventors: Amir H. Hoveyda, Joshua Van Veldhuizen, Steven B. Garber, Jason S. Kingsbury