Abstract: The present disclosure provides adenosine receptor (e.g., A2A and/or A1 receptor) antagonist compounds and compositions including said compounds. The present disclosure also provides methods of using said compounds and compositions for modulating (e.g., inhibiting or antagonizing) A2A and/or A1 receptor in a biological system. The compounds and compositions find use in various therapeutic applications including the treatment of cancer and in immuno-oncology. The compounds and compositions find use in various therapeutic applications including the treatment of central nervous system or neurodegenerative diseases, such as Parkinson’s disease.

Abstract: The present disclosure relates to pyrrolobenzodiazepine dimer prodrugs and ligand-linker conjugates thereof. The present disclosure also relates to compositions and uses of said prodrugs and conjugates.

Abstract: A substrate treating apparatus includes a housing, treating space and support unit to support a substrate, dielectric plate, gas supply unit, and plasma source to generate a plasma and including a top edge electrode above the edge region supported by the support unit and bottom edge electrode below the edge region supported by the support unit, which includes a support plate having an inner space and vacuum hole that communicates with the inner space and sucking the substrate on the top surface. A lift pin assembly can transfer the substrate between an outside transfer unit and the support plate. A decompression unit can apply negative pressure to the inner space. The lift pin assembly includes a base plate and through hole penetrating the base plate to provide negative pressure in a region under the base plate to a region over the base plate. Lift pins protrude from the base plate and support a bottom substrate surface. A driver can lift/lower the base plate within the inner space.

Abstract: A radio-frequency (RF) splitter is provided. The RF splitter includes a common branch node configured to transfer an RF signal, input from an input port, to at least one of first and second output ports, first and second branch nodes electrically connected between the common branch node and the first and second output ports, first and second series switches configured to control switching operations to electrically connect the common branch node and the first and second branch nodes to each other, first and second inductors electrically connected between the common branch node and the first and second branch nodes, a resistor electrically connected between the first and second branch nodes, and first and second shunt switches configured to control switching operations to electrically connect the first and second branch nodes and the resistor to each other.

Abstract: Disclosed is a method of providing information including obtaining input information of a user, wherein the input information is related to a service, determining whether an account corresponding to the user exists in the service, obtaining characteristic information of the user based on the result of the determination, providing response information corresponding to the input information based on the characteristic information and the result of the determination, and storing activity information of the user based on at least one of the input information, the response information, and the characteristic information.

Abstract: Disclosed is a method of providing information including obtaining input information of a user, wherein the input information is related to a service, determining whether an account corresponding to the user exists in the service, obtaining characteristic information of the user based on the result of the determination, providing response information corresponding to the input information based on the characteristic information and the result of the determination, and storing activity information of the user based on at least one of the input information, the response information, and the characteristic information.

Abstract: A manufacturing method of a display device includes providing a display panel including: a first area in which a plurality of pixels is arranged, a second area adjacent to the first area and at which the display panel is bendable, and a third area facing the first area with the second area therebetween; providing a circuit board electrically connected to the display panel at the third area; providing a first force to the third area of the display panel; and bending the second area of the display panel by the first force which is provided to the third area of the display panel.

Abstract: A display device includes a display panel, a lower module, a flexible circuit film, and a conductive adhesive tape. The display panel includes a first non-folding area, a second non-folding area, and a folding area. The lower module is disposed under the display panel. The flexible circuit film is coupled to the display panel, and a portion of the flexible circuit film is disposed on a rear surface of the lower module. The conductive adhesive tape is disposed between the lower module and the flexible circuit film. The conductive adhesive tape includes a conductive nonwoven fabric layer, a first conductive adhesive layer, and a second conductive adhesive layer. The first conductive adhesive layer is disposed between the conductive nonwoven fabric layer and the flexible circuit film, and the second conductive adhesive layer is disposed between the conductive nonwoven fabric layer and the lower module.

Abstract: An embodiment relates to a surface emitting laser device and a light emitting device including the same. The surface emitting laser device according to the embodiment may include a first reflective layer; an active layer disposed on the first reflective layer; an active region disposed on the active layer and having an aperture and an insulation region disposed around the aperture; and a second reflective layer disposed on the active region. The second reflective layer may include a core reflective layer disposed in a position vertically corresponding to the aperture. The embodiment may include a cladding insulation layer disposed around the core reflective layer. The horizontal cross-section of the aperture may be different from the horizontal cross-section of the core reflective layer.

Abstract: Disclosed are a novel antibody specifically binding to the tumor-immunosuppressant, TIGIT (T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif [ITIM] domain) or an antigen-binding fragment thereof, a nucleic acid encoding the antibody or the antigen-binding fragment thereof, a vector and a host cell including the nucleic acid, a method for producing the antibody or the antigen-binding fragment thereof, a pharmaceutical composition containing the antibody or the antigen-binding fragment thereof as an active ingredient, and uses of the pharmaceutical composition. The antibody specifically binding to TIGIT or the antigen-binding fragment thereof and the pharmaceutical composition containing the same as an active ingredient are preferably used for the treatment of cancer or tumors.

Abstract: An amplifying circuit is provided. The amplifying circuit includes a bias circuit receiving an operating voltage from a power supply circuit and generating a first bias voltage, a resistance circuit connected between the bias circuit and a gate node and transferring the first bias voltage to the gate node, a start-up circuit generating a high-level start-up voltage and supplying the start-up voltage to the gate node before the operating voltage is supplied, based on a control signal, and an amplifier started-up by receiving the start-up voltage and then receiving the operating voltage and the first bias voltage to amplify a high frequency signal input through the gate node.

Abstract: The present invention relates to a bellows framework having a concave-convex structure on at least one of outer and inner sides using three-dimensional printing technology and a method of producing thereof, and an artificial tracheal replacement comprising an epithelium part formed on the inner side of the bellows framework and an annular cartilage part formed along the circumference of concave-convex grooves on the outer side and a method of producing thereof.

Abstract: The inventive concept provides a substrate treating apparatus. The substrate treating apparatus includes a housing, a support unit including a chuck that supports a substrate, a gas supply unit, and a dielectric plate that faces an upper surface of the substrate supported by the chuck, a height of a lower surface of a central area of the dielectric plate and a height of a lower surface of an edge area of the dielectric plate are different, and a height of an upper surface of a central area of the chuck and a height of an upper surface of an edge area of the chuck are different.

Abstract: A front-end module is provided. The front-end module includes a reception amplifier configured to amplify a received radio-frequency (RF) signal, first and second series switches configured to control a switching operation to electrically connect an output terminal of the reception amplifier and first and second reception ports to each other, a radio-frequency (RF) splitter configured to simultaneously transfer a received RF signal, amplified by the reception amplifier or bypassing the reception amplifier, to the first and second reception ports, first and second shunt switches configured to control a switching operation to electrically connect a ground and first and second branch nodes between the RF splitter and the first and second reception ports to each other, and first and second reflected wave removing impedance elements electrically connected between the first and second branch nodes and a ground.

Abstract: A dual function protein is disclosed. The dual function protein may be prepared by linking a biologically active protein and an FGF mutant protein to an Fc region of an immunoglobulin. The dual function protein has improved pharmacological efficacy, in vivo duration and protein stability. The dual function protein exhibits improved pharmacological efficacy, in vivo duration and protein stability. A pharmaceutical composition containing the dual function protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver diseases, non-alcoholic steatohepatitis or cardiovascular diseases.

Abstract: A fusion protein comprises an FGF21 mutant protein and an Fc region of an immunoglobulin. The fusion protein exhibits improved pharmacological efficacy, in vivo duration and protein stability. A pharmaceutical composition containing the fusion protein as an active ingredient may be effectively used as a therapeutic agent for diabetes, obesity, dyslipidemia, metabolic syndrome, non-alcoholic fatty liver disease or non-alcoholic steatohepatitis.

Abstract: An amplifying circuit is provided. The amplifying circuit includes a bias circuit receiving an operating voltage from a power supply circuit and generating a first bias voltage, a resistance circuit connected between the bias circuit and a gate node and transferring the first bias voltage to the gate node, a start-up circuit generating a high-level start-up voltage and supplying the start-up voltage to the gate node before the operating voltage is supplied, based on a control signal, and an amplifier started-up by receiving the start-up voltage and then receiving the operating voltage and the first bias voltage to amplify a high frequency signal input through the gate node.

Abstract: A radio-frequency switching circuit includes a first switching circuit connected between a common capacitor connected to an antenna port and a first capacitor connected to a first port, and performing a switching operation with a first gate voltage transmitted through a first gate terminal, a voltage generation circuit supplying a drain-source voltage to a common node disposed at a first end of the first switching circuit, and a voltage detection circuit receiving a node voltage from the common node, comparing the node voltage with a reference voltage, and generating a detection voltage including damage information regarding the common capacitor or the first capacitor.

Abstract: A radio-frequency switching circuit includes a first switching circuit connected between a common capacitor connected to an antenna port and a first capacitor connected to a first port, and performing a switching operation with a first gate voltage transmitted through a first gate terminal, a voltage generation circuit supplying a drain-source voltage to a common node disposed at a first end of the first switching circuit, and a voltage detection circuit receiving a node voltage from the common node, comparing the node voltage with a reference voltage, and generating a detection voltage including damage information regarding the common capacitor or the first capacitor.

Abstract: A radio-frequency (RF) splitter is provided. The RF splitter includes a common branch node configured to transfer an RF signal, input from an input port, to at least one of first and second output ports, first and second branch nodes electrically connected between the common branch node and the first and second output ports, first and second series switches configured to control switching operations to electrically connect the common branch node and the first and second branch nodes to each other, first and second inductors electrically connected between the common branch node and the first and second branch nodes, a resistor electrically connected between the first and second branch nodes, and first and second shunt switches configured to control switching operations to electrically connect the first and second branch nodes and the resistor to each other.