Patents by Inventor Judit Matuz

Judit Matuz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6656921
    Abstract: The invention relates to pharmaceutical compositions against peptic ulcer as well as to a method of treating peptic ulcer. The compositions contain and the method of treatment employs zinc hyaluronate as an active ingredient having a molecular weight in the range of 500,000 to 1,200,000 daltons.
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: December 2, 2003
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Janos Illes, Judit Matuz, Erzsabet Neszmelyi, Gaborne Forrai, Bela Stefko, Katalin Saghy, Laszlo Szporny
  • Patent number: 5214045
    Abstract: Novel acrylic amide derivatives of the Formula (I) ##STR1## wherein R.sup.1 represents a hydrogen or a halogen atom or a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group.n is an integer of 0 to 2,A represents an amino acid residue derived from a naturally occurring amino acid or an antipode thereof which is bonded to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid, bonded to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C.sub.1-4 alkyl group or is amidated; or A represents a group of the formula ##STR2## wherein R.sub.2 is a hydrogen atom or a phenyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxycarbonyl group,and their salts which have cytoprotective and antiulcer to activities. A process is also described for the preparation of said compounds.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: May 25, 1993
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tamas Fodor, Janos Fischer, Laszlo Dobay, Elemer Ezer, Judit Matuz, Laszlo Szporny, Gyorgy Hajos
  • Patent number: 5169859
    Abstract: The present invention relates to novel compounds of the general formula (I) ##STR1## wherein R means hydrogen or C.sub.1-4 alkyl group; andY stands for cyano, trifluoromethyl, aryloxy or aryl(C.sub.1-4 alkyl)oxy group.The compounds according to the invention show a gastric acid secretion-inhibiting effect and therefore, they are useful for the treatment of gastric and duodenal ulcers. In addition, they exert a cytoprotective action against gastric laesions induced, e.g. by indomethacin or acid-containing alcohol.
    Type: Grant
    Filed: July 18, 1991
    Date of Patent: December 8, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Istvan Szabadkai, Kalman Harsanyi, Zsoltne Szabo, Bela Hegedus, Elemer Ezer, Judit Matuz, Laslo Szporny, Katalin Saghy, Gyorgy Hajos, Attila Csehi, Gabor Balogh
  • Patent number: 5155123
    Abstract: The invention relates to novel pyridine derivatives of formula (I), ##STR1## wherein Q stand for a nitro or cyano group; andX.sup.1 and X.sup.2, independently from each other, represent hydrogen or halogen or a trifluoromethyl, a lower alkyl or alkoxy or nitro group bound to any of the carbon atoms of the phenyl ring.The invention further relates to pharmaceutical compositions containing these compounds and a process for their preparation.The compounds of formula (I) possess gastric acid secretion inhibiting, tissue-protecting, analgetic and mild antiinflammatory effects and are useful for therapeutical purposes.
    Type: Grant
    Filed: October 31, 1990
    Date of Patent: October 13, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar R.T.
    Inventors: Gyorgy Domany, Elemer Ezer, Istvan Schon, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Marta Renyei
  • Patent number: 5106846
    Abstract: The present invention relates to compounds of the general formula (I), ##STR1## wherein R.sub.1 stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or nitro group;R.sub.2 means a C.sub.1-7 alkyl group optionally substituted by: a hydroxyl or oxo group; or an ester group containing 1 to 4 carbon atoms in the alkoxy moiety; or a C.sub.1-4 alkoxy, cyano, amino, C.sub.1-4 alkylamino, or dialkylamino group; or an acyl group containing 1 to 7 carbon atoms in the alkyl moiety; orR.sub.2 means an aryl-C.sub.1-7 alkyl group optionally bearing the substituents defined above for R.sub.2 in the alkyl chain and optionally substituted by halogen, nitro, C.sub.1-4 alkyl or alkoxy group in the benzene ring; orR.sub.2 represents an allyl, phenylallyl or phenylsulfonyl group, both latter groups optionally being substituted by halogen or a C.sub.1-4 alkyl group in the benzene ring; orR.sub.2 stands for a carbamoyl group substituted by one or two C.sub.1-4 alkyl group(s) or phenyl group on the nitrogen atom.
    Type: Grant
    Filed: July 10, 1990
    Date of Patent: April 21, 1992
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Istvan Szabadkai, Kalman Harsanyi, Agnes Lampert, Gyorgy Domany, Bela Hegedus, Elemer Ezer, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Krisztina Szekely
  • Patent number: 5037830
    Abstract: The present invention relates to novel compounds of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently from each other, for hydrogen, C.sub.1-4 alkyl, phenyl, phenyl-C.sub.1-4 alkyl, piridyl or piridyl-C.sub.1-4 alkyl group;E means a straight or branched, saturated hydrocarbon chain containing 1 to 6 carbon atoms;R.sub.3 represents: a phenyl group ortho-substituted by a C.sub.2-5 alkanoylamino, N-C.sub.2-5 alkanoyl-N-C.sub.1-4 alkylamino or di(C.sub.1-4 alkyl)amino group and optionally further substituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.2-5 alkanoyloxy group; or a pyridyl group optionally mono- or polysubstituted by halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.2-5 alkanoyloxy or phenyl-C.sub.1-4 alkoxy groupas well as their acid addition salts and tautomeric forms of these compounds.
    Type: Grant
    Filed: March 29, 1990
    Date of Patent: August 6, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Gabor Zolyomi, Ferenc Andrasi, Pal Berzsenyi, Elemer Ezer, Tibor Hasko, Erzsebet F. Birkas, Erno Koltai, Judit Matuz, Lajos Toldy, Laszlo Sebestyen, Zsuzsanna Fittler, Katalin Saghy, Laszlo Szporny, Peter Aranyi
  • Patent number: 5021597
    Abstract: Novel acrylic acid salts of formula ##STR1## wherein R represents a hydrogen or a halogen atom, a C.sub.1-4 alkyl, a C.sub.1-4 alkoxy or a nitro group,M represents a cation derived from bismuth, zinc or a pharmaceutically acceptable organic base,X represents an inorganic anion,n is an integer of from 0 to 2,m is an integer of from 1 to 3,p is 0 or 1, andr is an integer of from 0 to 6having cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: June 4, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Tamas Fodor, Janos Fischer, Laszlo Dobay, Ferenc Trischler, Elemer Ezer, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos
  • Patent number: 4990524
    Abstract: The present invention relates to a method of treating a gastric ulcer by administering a 2-thia-zolone of the formula (I), ##STR1## wherein X stands for --CN, --CONH.sub.2, --CO.sub.2 H or --CO.sub.2 R group, wherein R is a C.sub.1-5 alkyl group; andn is 0, 1 or 2, with the proviso, that when X stands for CO.sub.2 H, CO.sub.2 R, n is other than 0.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: February 5, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar RT.
    Inventors: Peter Bod, Kalman Harsanyi, Ferenc Trischler, Eva Fekecs, Bela Hegedus, Elemer Ezer, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Krisztina Szekely
  • Patent number: 4937252
    Abstract: The present invention relates to novel 2-thiazolidinone derivatives of the general formula (I), ##STR1## wherein A stands for hydrogen, halogen or a C.sub.1-4 alkyl, C.sub.1-4 alkoxy or nitro group; andn is 0 or 1.The compounds according to the invention show a cytoprotective and gastric acid secretion-inhibiting effect and thus, may be used in the therapy of gastric and duodenal ulcers.
    Type: Grant
    Filed: December 13, 1988
    Date of Patent: June 26, 1990
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Istvan Szabadkai, Kalman Harsanyi, Agnes Lampert, Gyorgy Domany, Bela Hegedus, Marta K. Pap, Elemer Ezer, Judit Matuz, Katalin Saghy, Laszlo Szporny, Gyorgy Hajos, Kristztina Szekely
  • Patent number: 4923888
    Abstract: The present invention relates to novel compounds of the general formula (I), ##STR1## wherein R stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 acylamino group;R.sub.1 means hydrogen or a carboxyl-protective group; andR.sub.2 represents a --(CH.sub.2).sub.n --CO.sub.2 R.sub.5 group, whereinn is 1, 2, 3 or 4; andR.sub.5 stands for hydrogen or a carboxyl-protective group; orR.sub.2 means a --(CH.sub.2).sub.n --NH.sub.2 group, whereinn is 1, 2, 3 or 4of E and/or Z configurtion as well as their salts.The compounds according to the invention show a cytoprotective effect and promote the healing of the stomach ulcer. Their toxicity is low.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: May 8, 1990
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Tamas Fodor, Laaszlo Dobay, Jaanos Fischer, Bela Stefkoo, Elemeer Ezer, Judit Matuz, Katalin Saghy, Laaszlo Szporny
  • Patent number: 4879404
    Abstract: The present invention relates to novel compounds of the general formula (I), ##STR1## wherein R stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or a C.sub.1-4 acylamino group; andR.sup.1 is hydrogen or a carboxyl-protective group or E and/or Z configuration as well as their salts.The compounds according to the invention show a cytoprotecive effect and in addition, a valuable anti-inflammatory action. Their toxicity is low.
    Type: Grant
    Filed: September 26, 1988
    Date of Patent: November 7, 1989
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt
    Inventors: Janos Fischer, Laszlo Dobay, Mihaly Major, Elemer Ezer, Judit Matuz, Katalin Saghy, Gyorgy Hajos, Laszlo Szporny
  • Patent number: 4782052
    Abstract: The invention relates to new 1,2,3,4,6,7,12,12b-octahydroindolo[2,3,-a]quinolizin-1-yl-alkanecarboxylic acid amides of the formula (I), ##STR1## wherein R.sub.1 and R.sub.2 stand independently for a hydrogen or halogen atom, or a hydroxyl, nitro or C.sub.1-4 alkoxy group;R.sub.3 and R.sub.4 stand independently for a hydrogen atom or a C.sub.1-4 alkyl group;R.sub.5 and R.sub.6 stand independently for a hydrogen atom, C.sub.1-8 alkyl group, C.sub.3-8 alkenyl or cycloalkyl group, aryl or aralkyl group, heteroaryl or heteroaralkyl group containing oxygen, nitrogen or sulphur atom, all these groups being optionally substituted; orR.sub.5 and R.sub.6 together form an optionally substituted C.sub.2-8 .alpha.,.omega.-alkylene group, wherein one carbon atom may optionally be replaced by an oxygen or nitrogen atom; andG means a C.sub.1-4 straight chained alkylene group, as well as to their therapeutically suitable acid addition salts and pharmaceutical compositions containing these compounds.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: November 1, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Ferenc Soti, Csaba Szantay, Maria Incze, Zsuzsanna Balogh nee Kardos, Elemer Ezer, Judit Matuz, Laszlo Szporny, Gyorgy Hajos, Csaba Kuthi
  • Patent number: 4762944
    Abstract: The invention relates to novel butenoic acid derivatives of the general formula (Ia) having E-configuration ##STR1## as well as to their Z-izomers of the general formula ##STR2## wherein R stands for a (-)-menthyl or a (+)-menthyl group. as well as pharmaceutical compositions containing these compounds.The novel butenoic acid derivatives of the general formulae (Ia) and (Ib) possess valuable pharmacological properties, mainly gastric cytoprotective effect.
    Type: Grant
    Filed: March 13, 1987
    Date of Patent: August 9, 1988
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Janos Fischer, Laszlo Dobay, Elemer Ezer, Judit Matuz, Laszlo Szporny, Tibor Wagner
  • Patent number: 4713388
    Abstract: The invention relates to new 2-pyridine-thiol derivatives of the formula (I), ##STR1## wherein R is hydrogen or alkyl having from 1 to 4 carbon atoms,Z is phenyl optionally substituted by one or more halogen atoms and/or alkyl groups having from 1 to 4 carbon atoms,R.sup.1 and R.sup.2 each independently represents hydrogen, alkyl having from 1 to 4 carbon atoms, alkylphenyl having from 1 to 4 carbon atoms in the alkyl moiety or an ##STR2## group, in which R has the same meaning as defined above, and the substituent ##STR3## is attached to the pyridine ring in the position 3 or 4, with the proviso that if R.sup.1 and R.sup.2 are both methyl and Z is 4-chlorophenyl, R is other than hydrogen, and acid addition salts thereof.The invention further relates to processes for the preparation of the above compounds and to pharmaceutical compositions containing them as active ingredient.The compounds are pharmaceutically active, in particular show cytoprotective activity.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: December 15, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka V. Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Csaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas, Anna Kallay
  • Patent number: 4691017
    Abstract: New intermediate compounds of the formula (I) are disclosed ##STR1## wherein R is hydrogen or C.sub.1 to C.sub.4 alkyl;Z is phenyl optionally substituted by one or more halogen atoms and/or alkyl groups having 1 to 4 carbon atoms; andD is hydroxy, mesyloxy, p-tosyloxy, or halogen; or pharmaceutically acceptable acid addition salt thereof. The compounds of the Formula (I) are intermediates in the preparation of new compounds having anti-ulcer activity.
    Type: Grant
    Filed: September 26, 1986
    Date of Patent: September 1, 1987
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka Vikar nee Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Osaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas nee Pap, Anna Kallay nee Sohonyai
  • Patent number: 4624959
    Abstract: The compound N-{2-[(3-benzoyl-1-pyridyl)-thio]-ethyl}-N'-cyano-S-methyl-isothiourea and pharmaceutically acceptable acid addition salts thereof are disclosed as well as pharmaceutical compositions containing same and a method of treatment employing same. The compound or its acid addition salts are effective in treating gastric oedema and thus are useful in ulcer therapy.
    Type: Grant
    Filed: October 3, 1985
    Date of Patent: November 25, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Elemer Ezer, Kalman Harsanyi, Hajnalka Vikar nee Petho, Judit Matuz, Laszlo Szporny, Eszter Cholnoky, Csaba Kuthi, Ferenc Trischler, Bela Hegedus, Marta Kapolnas nee Pap, Anna Kallay nee Sohonyai
  • Patent number: 4616025
    Abstract: New thiazolidine compounds of the formula (I) having anti-ulcer activity are disclosed: ##STR1## wherein Ar is a 2-furyl or a phenyl, naphthyl or pyridyl group optionally substituted by one or more C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy, halo-C.sub.1-4 -alkoxy, dihalomethyl, trihalomethyl, hydroxyl or nitro groups or by a group of the formula (II), ##STR2## wherein Y is nitrogen or CH;Z is cyano or carbamoyl if Y is nitrogen, and represents a nitro group if Y is CH.Also disclosed are several processes for preparing the new compounds as well as pharmaceutical compositions and method of treatment employing same.
    Type: Grant
    Filed: March 16, 1984
    Date of Patent: October 7, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Elemer Ezer, Kalman Harsanyi, Gyorgy Domany, Laszlo Szporny, Judit Matuz, Bela Hegedus, Katalin Pallagi, Istvan Szabadkai, Peter Tetenyi