Patents by Inventor Jukka Tuominen
Jukka Tuominen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200283568Abstract: Provided herein is a bioresorbable polyester wherein the metal content of the polyester is >0 ppm and <40 ppm, a controlled release pharmaceutical composition containing such polyesters, and a kit for injecting a controlled release pharmaceutical composition. Also provided herein is a method of purifying a bioresorbable polyester with a metal content >0 ppm comprising the steps of: i) dissolving the polyester in an organic solvent to form a polyester-solvent solution, wherein the organic solvent comprises at least one heteroatom selected from oxygen, nitrogen, sulphur and phosphorus; ii) precipitating the polyester from the polyester-solvent solution by combining the polyester-solvent solution with an organic non-solvent, said non-solvent being an alcohol; and (iii) separating the precipitated polyester from the solvent and non-solvent to obtain a purified polyester.Type: ApplicationFiled: November 20, 2018Publication date: September 10, 2020Inventors: Jonathan Glen, Harri Jukarainen, Jukka Tuominen
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Patent number: 10105445Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.Type: GrantFiled: February 6, 2015Date of Patent: October 23, 2018Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Alexander Livingstone, Janet Anne Halliday
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Patent number: 9987364Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: GrantFiled: December 6, 2013Date of Patent: June 5, 2018Assignee: Ferring B.V.Inventors: Janet Anne Halliday, Jukka Tuominen, Mark Alexander Livingstone, Frank Koppenhagen, Lilias Morton Currie, Sarah Stewart
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Patent number: 9381277Abstract: Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibers manufactured from these glass compositions, medical devices containing fibers of the invention, the use of these compositions for the manufacture of glass fiber and the use of the fibers for the manufacture of medical devices are also disclosed.Type: GrantFiled: April 4, 2014Date of Patent: July 5, 2016Assignee: Purac Biochem bvInventors: Timo Lehtonen, Jukka Tuominen, Fredrik Ollila
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Patent number: 9289534Abstract: A composite material including biocompatible and bioresorbable glass, a biocompatible and bioresorbable matrix polymer and a coupling agent capable of forming covalent bonds. The composite also includes a compatibilizer, where at least 10% of the structural units of the compatibilizer are identical to the structural units of the matrix polymer, and the molecular weight of the compatibilizer is less than 30000 g/mol. The use of this composite, a medical device which includes the composite and a method for preparing the composite are also disclosed.Type: GrantFiled: April 22, 2010Date of Patent: March 22, 2016Assignee: Purac Biochem bvInventors: Timo Lehtonen, Jukka Tuominen
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Publication number: 20150165044Abstract: This disclosure relates to a controlled-release composition containing a water-swellable linear polymer together with an active agent. The water-swellable linear polymer is obtained by reacting together: (a) a polyethylene oxide of number average molecular weight less than or equal to 4000 g/mol; (b) an aliphatic diol; and (c) a difunctional isocyanate. The ratio of components (a) to (b) to (c) is in the range of 0.01-0.1 to 1 to 1.01-1.1 in terms of equivalent weights. The amount of the polyethylene oxide is less than 50 wt % of the polymer. The polymer has a water swelling percentage of 20-100%.Type: ApplicationFiled: February 6, 2015Publication date: June 18, 2015Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Alexander Livingstone, Janet Anne Halliday
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Patent number: 8974813Abstract: A water-swellable linear polymer is made by reacting together a polyethylene oxide of number average molecular weight less than 4,000, an aliphatic diol, and a difunctional diisocyanate. Controlled release composition comprises the polymer together with an active agent. The polymer is able to take up pharmaceutically active agents of molecular weight 200 to 20,000.Type: GrantFiled: June 27, 2007Date of Patent: March 10, 2015Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Patent number: 8858976Abstract: The present invention relates to an implantable paste comprising bioactive glass spheres having a size distribution of 50-425 ?m, low molecular weight polyethylene glycol having a molecular weight range of 200-700 g/mol, medium molecular weight polyethylene glycol having a molecular weight range of 700-2500 g/mol and high molecular weight polyethylene glycol having a molecular weight range of 2500-8000 g/mol, with the proviso that the molecular weight of the low molecular weight polyethylene glycol and of the medium molecular weight polyethylene glycol differ from each other by at least 80 g/mol and that the molecular weight of the medium molecular weight polyethylene glycol and of the high molecular weight polyethylene glycol differ from each other by at least 300 g/mol.Type: GrantFiled: November 12, 2010Date of Patent: October 14, 2014Assignee: Bonalive Biomaterials OyInventors: Jukka Tuominen, Timo Lehtonen, Fredrik Ollila
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Publication number: 20140220338Abstract: Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibres manufactured from these glass compositions, medical devices containing fibres of the invention, the use of these compositions for the manufacture of glass fibre and the use of the fibres for the manufacture of medical devices are also disclosed.Type: ApplicationFiled: April 4, 2014Publication date: August 7, 2014Applicant: PURAC BIOCHEM BVInventors: Timo LEHTONEN, Jukka TUOMINEN, Fredrik OLLILA
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Publication number: 20140107195Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: ApplicationFiled: December 6, 2013Publication date: April 17, 2014Applicant: Ferring B.V.Inventors: Janet Anne Halliday, Jukka Tuominen, Mark Alexander Livingstone, Frank Koppenhagen, Lilias Morton Currie, Sarah Stewart
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Patent number: 8628798Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: GrantFiled: August 10, 2012Date of Patent: January 14, 2014Assignee: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Patent number: 8557281Abstract: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.Type: GrantFiled: July 13, 2010Date of Patent: October 15, 2013Assignee: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Patent number: 8524254Abstract: A bioresorbable polymer is obtained by reacting together (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties; (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C2-C6 diol; and (c) a diisocyanate. The polymer may be loaded with a pharmaceutically active agent to produce a drug delivery device.Type: GrantFiled: October 15, 2007Date of Patent: September 3, 2013Assignee: Ferring B.V.Inventors: Donald Magnus Nicolson, Janet Anne Halliday, Jukka Tuominen, Amaia Zurutuza
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Patent number: 8361272Abstract: A linear polymer is obtained by reacting together a polyethylene glycol or polypropylene glycol; a PEG-PPG-PEG or PPG-PEG-PPG block copolymer; a difunctional amine or diol; and a diisocyanate. A controlled release composition comprises the polymer together with an active agent. Active agents of molecular weight 200 to 20,000 may be used.Type: GrantFiled: June 27, 2007Date of Patent: January 29, 2013Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet Anne Halliday
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Patent number: 8361273Abstract: This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.Type: GrantFiled: September 6, 2012Date of Patent: January 29, 2013Assignee: Ferring B.V.Inventors: Jukka Tuominen, Amaia Zurutuza, Mark Livingstone, Janet A. Halliday
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Publication number: 20120329883Abstract: This disclosure relates to a linear polymer obtained by reacting a polyethylene glycol, a polypropylene glycol; a diol; and a diisocyanate, as well as a controlled release composition containing the linear polymer together with an active agent. The active agent can have a molecular weight of 200 g/mol to 20,000 g/mol.Type: ApplicationFiled: September 6, 2012Publication date: December 27, 2012Inventors: Jukka Tuominen, AMAIA ZURUTUZA, MARK LIVINGSTONE, JANET ANNE HALLIDAY
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Publication number: 20120302635Abstract: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.Type: ApplicationFiled: August 10, 2012Publication date: November 29, 2012Applicant: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Publication number: 20120276164Abstract: The present invention relates to an implantable paste comprising bioactive glass spheres having a size distribution of 50-425 ?m, low molecular weight polyethylene glycol having a molecular weight range of 200-700 g/mol, medium molecular weight polyethylene glycol having a molecular weight range of 700-2500 g/mol and high molecular weight polyethylene glycol having a molecular weight range of 2500-8000 g/mol, with the proviso that the molecular weight of the low molecular weight polyethylene glycol and of the medium molecular weight polyethylene glycol differ from each other by at least 80 g/mol and that the molecular weight of the medium molecular weight polyethylene glycol and of the high molecular weight polyethylene glycol differ from each other by at least 300 g/mol.Type: ApplicationFiled: November 12, 2010Publication date: November 1, 2012Inventors: Jukka Tuominen, Timo Lehtonen, Fredrik Ollila
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Publication number: 20120040002Abstract: Biocompatible and resorbable melt derived glass compositions which include: SiO2 60-70 weight-%, Na2O 5-20 weight-%, CaO 5-25 weight-%, MgO 0-10 weight-%, P2O5 0.5-3.0 weight-%, B2O3 0-15 weight-%, Al2O3 0-5 weight-%, and which contain less than 0.05 weight-% potassium. Biocompatible and resorbable glass fibres manufactured from these glass compositions, medical devices containing fibres of the invention, the use of these compositions for the manufacture of glass fibre and the use of the fibres for the manufacture of medical devices are also disclosed.Type: ApplicationFiled: April 20, 2010Publication date: February 16, 2012Inventors: Timo Lehtonen, Jukka Tuominen, Fredrik Ollila
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Publication number: 20120040015Abstract: A composite material including biocompatible and bioresorbable glass, a biocompatible and bioresorbable matrix polymer and a coupling agent capable of forming covalent bonds. The composite also includes a compatibilizer, where at least 10% of the structural units of the compatibilizer are identical to the structural units of the matrix polymer, and the molecular weight of the compatibilizer is less than 30000 g/mol. The use of this composite, a medical device which includes the composite and a method for preparing the composite are also disclosed.Type: ApplicationFiled: April 22, 2010Publication date: February 16, 2012Inventors: Timo Lehtonen, Jukka Tuominen