Patents by Inventor Julie F. Liu

Julie F. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120071554
    Abstract: Described herein are novel analogs of 2-propylpentanoic acid, pharmaceutical compositions comprising the same, and methods of using the same for the treatment of diseases or conditions that are beneficially treated by administering a GABAAergic transmission enhancer and/or a histone deacetylase (HDAC) inhibitor.
    Type: Application
    Filed: October 28, 2009
    Publication date: March 22, 2012
    Inventor: Julie F. Liu
  • Publication number: 20120058085
    Abstract: This invention relates to derivatives of 1-(p-chlorobenzyl)-2-(1-pyrrolidinylmethyl)benzimidazole according to Formula I wherein at least one Y is deuterium described herein and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of hepatitis C virus (HCV) RNA replication.
    Type: Application
    Filed: May 14, 2010
    Publication date: March 8, 2012
    Inventors: Rose A. Persichetti, Julie F. Liu, Adam Morgan
  • Patent number: 8124646
    Abstract: This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
    Type: Grant
    Filed: June 15, 2010
    Date of Patent: February 28, 2012
    Assignee: Concert Pharmaceuticals, Inc.
    Inventor: Julie F. Liu
  • Publication number: 20110301113
    Abstract: This invention relates to novel compounds that are pyrimidineamine derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel pyrimidineamine derivatives that are derivatives of pazopanib. This invention also provides compositions comprising one or more compound of this invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering a VEGFR (1-3) inhibitor, such as pazopanib.
    Type: Application
    Filed: September 24, 2009
    Publication date: December 8, 2011
    Inventor: Julie F. Liu
  • Patent number: 8013007
    Abstract: This invention relates to novel compounds that are dihydroindoles derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel dihydroindoles derivatives that are derivatives of silodosin. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an ?-1A-adrenoreceptor antagonist, such as silodosin.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: September 6, 2011
    Assignee: Concert Pharmaceuticals, Inc.
    Inventor: Julie F. Liu
  • Publication number: 20110196012
    Abstract: This invention relates to novel macrocyclic protease inhibitors and their pharmaceutically acceptable salts thereof. This invention also provides compositions comprising at least one compound of this invention and the use of such compositions in methods of treating a flavivirus infection or liver fibrosis in a patient in need thereof.
    Type: Application
    Filed: April 22, 2011
    Publication date: August 11, 2011
    Applicant: Concert Pharmaceuticals, Inc.
    Inventor: Julie F. Liu
  • Publication number: 20110172280
    Abstract: This invention relates to novel substituted benzimidazoles and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound that modulates the GABAA receptor. This invention also provides novel intermediates for the preparation of the compounds of the invention, and salts thereof.
    Type: Application
    Filed: October 15, 2010
    Publication date: July 14, 2011
    Applicant: CoNCERT Pharmaceuticals, Inc.
    Inventors: Julie F. Liu, Scott L. Harbeson
  • Publication number: 20110152227
    Abstract: This invention relates to novel derivatives of tolterodine, 5-hydroxymethyl tolterodine, fesoterodine and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by muscarinic receptor antagonists.
    Type: Application
    Filed: April 9, 2009
    Publication date: June 23, 2011
    Applicant: CONCERT PHARMACEUTICALS INC.
    Inventor: Julie F. Liu
  • Publication number: 20110129549
    Abstract: This invention relates to deuterated lonafamib and pharmaceutically acceptable salts. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering Lonafamib as an inhibitor of the enzyme farnesyl transferase; an inducer of cellular apoptosis (programmed cell death); and an inhibitor of cellular transduction pathways.
    Type: Application
    Filed: April 16, 2009
    Publication date: June 2, 2011
    Inventor: Julie F. Liu
  • Publication number: 20110092468
    Abstract: This invention relates to novel calcimimetic compounds, their derivatives, pharmaceutically acceptable salts, solvates, and hydrates thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by binding to, and modulating the sensitivity of, calcium receptors on the parathyroid gland.
    Type: Application
    Filed: December 22, 2010
    Publication date: April 21, 2011
    Applicant: CONCERT PHARMACEUTICALS INC.
    Inventors: Julie F. Liu, Jillian Imagire
  • Publication number: 20110082147
    Abstract: This invention relates to novel substituted imidazotriazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound showing partial-agonist activity at the GABA ?2, ?3 and ?5 subtype receptors, and antagonist activity at the al subtype receptor.
    Type: Application
    Filed: July 23, 2010
    Publication date: April 7, 2011
    Applicant: CoNCERT Pharmaceuticals, Inc.
    Inventors: Scott L. Harbeson, Roger D. Tung, Julie F. Liu
  • Publication number: 20110077255
    Abstract: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 31, 2011
    Inventors: Roger D. Tung, Julie F. Liu, Scott L. Harbeson
  • Publication number: 20110065711
    Abstract: This invention relates to novel substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an ?1-GABAA receptor antagonist or an ?2- and/or an ?3-GABAA receptor partial agonist.
    Type: Application
    Filed: June 22, 2010
    Publication date: March 17, 2011
    Applicant: CoNCERT Pharmaceuticals, Inc.
    Inventors: Scott L. Harbeson, Roger D. Tung, Julie F. Liu
  • Publication number: 20110059995
    Abstract: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 10, 2011
    Inventors: Roger D. Tung, Julie F. Liu, Scott L. Harbeson
  • Publication number: 20110053961
    Abstract: This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.
    Type: Application
    Filed: September 1, 2010
    Publication date: March 3, 2011
    Inventors: Roger D. Tung, Julie F. Liu, Scott L. Harbeson
  • Publication number: 20100324108
    Abstract: This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.
    Type: Application
    Filed: June 15, 2010
    Publication date: December 23, 2010
    Inventor: Julie F. LIU
  • Publication number: 20100305173
    Abstract: This invention relates to novel hydroxyethylamino sulfonamides, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound with the ability to act as an HIV (human immunodeficiency virus) protease inhibitor.
    Type: Application
    Filed: April 30, 2010
    Publication date: December 2, 2010
    Applicant: CoNCERT Pharmaceuticals, Inc.
    Inventors: Scott L. Harbeson, Roger D. Tung, Julie F. Liu, Craig E. Masse
  • Publication number: 20100249079
    Abstract: This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.
    Type: Application
    Filed: December 22, 2009
    Publication date: September 30, 2010
    Inventors: Rose A. Persichetti, Julie F. Liu, Craig E. Masse, Scott L. Harbeson
  • Publication number: 20100221221
    Abstract: This disclosure relates to novel N-phenyl-2-pyrimidineamines and pharmaceutically acceptable salts thereof. This disclosure also provides compositions comprising a compound of this disclosure and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering protein-tyrosine kinase inhibitors.
    Type: Application
    Filed: August 11, 2009
    Publication date: September 2, 2010
    Applicant: CONCERT PHARMACEUTICALS INC.
    Inventors: Scott L. Harbeson, Julie F. Liu, Roger Tung
  • Publication number: 20100160247
    Abstract: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.
    Type: Application
    Filed: June 17, 2009
    Publication date: June 24, 2010
    Applicant: CoNCERT Pharmaceuticals, Inc.
    Inventors: Julie F. Liu, Xuejun Tang, Scott L. Harbeson, Craig E. Masse