Abstract: Compounds with KRAS G12C inhibitory active are disclosed and methods of using the same to treat a cancer comprising a K-Ras G12C mutation.

Abstract: Described herein are small molecule splicing modulator compounds that modulate splicing of mRNA, such as pre-mRNA, encoded by genes, pharmaceutical compositions comprising the same, and methods of use of the small molecule splicing modulator compounds for modulating splicing and treating diseases and conditions.

Abstract: The present disclosure relates to a crystal form of a pyridopyrimidine derivative and a preparation method thereof, and specifically relates to the crystal form of the compound of formula (I) and a preparation method thereof. The new crystal form has good physical and chemical properties, thereby facilitating clinical treatments.

Abstract: The present invention provides a cardiac ablation system including a spline assembly and a catheter wire. The spline assembly is provided with a plurality of electrodes and a plurality of first conductive layers encapsulated therein. A total number of the plurality of first conductive layers is corresponding to a total number of the plurality of electrodes. Each of the plurality of first conductive layers is electrically connected to each of the plurality of electrodes. The spline assembly is configured to transform into various configurations along a radial direction. A distal end of the catheter wire is connected to a proximal end of the spline assembly. The catheter wire includes a plurality of second conductive layers encapsulated therein. A total number of the plurality of second conductive layers is corresponding to the total number of the plurality of first conductive layers.

Abstract: The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

Abstract: An NFC QR code label according to the present invention comprises: a rectenna for receiving a radio frequency signal from a terminal device and converting the signal into DC power; a ring oscillator activated by receiving the DC power supplied from the rectenna, and producing an oscillation signal having a predetermined frequency; and a light-emitting QR code flickering in response to the oscillation signal. The light-emitting QR code includes a QR code pattern formed by means of gravure printing using a nonconductor ink.

Abstract: This invention shows a type of dual-sensing basin faucet, includes the shell of faucet, the shell of this faucet is setting a valve seat with adjustment switch. The top of valve seat is connected to the cavity of water outlet and cavity of solenoid valve. There is the outlet tube inside the cavity of water outlet and a solenoid valve inside the cavity of solenoid valve. Both outlet tube and solenoid valve are setting inside the shell of this faucet. There is circuit board setting on the top of outlet tube, and the circuit board is electrically connected with the solenoid valve. There is a support plate that is setting above the circuit board and is firmly connected with the circuit board.

Abstract: A system for controlling voltage operation of a power supply unit (PSU) for an information handling system. If the PSU is established as a High-Line power supply and is a dual wattage unit, Low-Line capabilities are disabled and the PSU turns off if power drops below a High-Line minimum voltage. If the PSU is established as a Low-Line PSU or is not dual wattage unit, the PSU is maintained in a current operational state and is either reset or turned off before making changes.

Abstract: A camera module is provided. The camera module may be separately used as a camera, or may be applied to a terminal device such as a mobile phone or a tablet computer, or a vehicle-mounted device. The camera module includes an optical lens component, a light filtering layer, an image sensor and a drive module. The optical lens component is configured to receive a light beam from a photographed object, and transmit the light beam to the light filtering layer. The light filtering layer is configured to move a position under the drive of the drive module, and respectively transmit light signals filtered at different positions to the image sensor. The image sensor is configured to receive the light signals at the different positions from the light filtering layer, and determine image information based on the light signals at the different positions.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, prodrug or stereoisomer thereof, wherein R1, R2a, R3a, R3b, R4a, R4b, G1, G2, L1, L2, m1, m2, A, B, W, X, Y, Z and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: Disclosed is a method for preparing a benzofuran derivative. In particular, provided is a method for preparing a benzofuran derivative, wherein according to the method provided, reaction steps required to synthesize the benzofuran substance in the prior art can be effectively shortened.

Abstract: A camera module is disclosed, which has a compact structure, and may be used as a camera alone, or may be used in a terminal device such as a mobile phone or a tablet computer or in a vehicle-mounted device. The camera module includes two magnetic bodies, a lens group, a zooming coil, and a sensor, where the two magnetic bodies are respectively located on two opposite sides of the lens group, to form a magnetic field; the lens group includes a first soft film lens; the zooming coil is connected to a soft film of the first soft film lens; when the zooming coil is energized, a Lorentz force is generated under action of the magnetic field, to change a shape of the first soft film lens, and implement a zooming function; and the sensor is configured to receive a light beam incident through the lens group.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form or prodrug thereof, wherein R1, R2a, R2b, R2c, R3a, R3b, R4a, R4b, R5, L1, L2, L3, E, m1, m2 and * are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: A method of promoting adhesion between a dielectric layer of a semiconductor device and a metal fill deposited within a trench in the dielectric layer, including performing an ion implantation process wherein an ion beam formed of an ionized dopant species is directed into the trench at an acute angle relative to a top surface of the dielectric layer to form an implantation layer in a sidewall of the trench, and depositing a metal fill in the trench atop an underlying bottom metal layer, wherein the metal fill adheres to the sidewall.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, wherein B, Z, Ra, Rb, Rc, R1, L, L1 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.

Abstract: An optical image stabilization apparatus includes a first lens, a first reflector, a position sensor, a control component, and a housing configured to enclose the first lens and the first reflector, where the position sensor is connected to the control component. An optical signal is transmitted to the first reflector after passing through the first lens. The first reflector reflects the received optical signal, and the reflected optical signal is projected onto an imaging plane. The position sensor is configured to detect shaking information of the first lens and send the shaking information to the control component. The control component is configured to control, based on the shaking information, the first reflector to rotate by using a first preset direction as an axis, where the first preset direction is a direction that is not parallel to a normal direction of the first reflector.

Abstract: This application discloses an optical module, including a light passing hole, an optical splitter, an optical imaging apparatus, and an optical apparatus, where light entering from the light passing hole is incident on the optical splitter; the optical splitter is configured to split the incident light into two parts, one part of the light enters the optical imaging apparatus, and the other part of the light enters the optical apparatus; the optical imaging apparatus is configured to collect a first image; and the optical apparatus is configured to collect a second image, or the optical apparatus is configured to implement an optical detection function.

Abstract: An automatic focus apparatus for a camera module includes a voice coil motor and a driving unit. The voice coil motor includes a frame, a moving member with a lens, and a magnetic member. The magnetic member is positioned at a side wall of the moving member, the driving unit is positioned at a side plate of the frame. A magnetic field is generated by the driving unit and the magnetic member, the magnetic field drives the moving member with the lens to move, to achieve automatic focus.

Abstract: A compound of Formula (I) is provided: where the variables are defined herein.

Abstract: Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, isotopic form or stereoisomer thereof, wherein A is a five-membered heteroaryl comprising 1 or 2 non-adjacent heteroatoms, inclusive of X and Y; W, X, Y, Z, L, L1, E, R1, R2b R2c and the dotted circle are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and compounds for use in methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided. Preferred compounds are e.g. 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and related compounds such as e.g. the corresponding derivatives with e.g. a benzoimidazole, indole, benzooxazole, imidazopyridine or imidazole core structure, substituted on ring A by e.g.