Abstract: An upper is provided for a shoe. The upper is basically provided with a base layer, a first reinforcement layer and a second reinforcement layer. The base layer includes a toe portion and a heel portion. The base layer has a joint free three-dimensional shape at least partly defining an interior foot receiving space. The first reinforcement layer is disposed on an outer side of a centerline of a toe-heel direction of the upper. The first reinforcement layer overlies a first heel area of the heel portion. The second reinforcement layer is disposed on an inner side of the centerline. The second reinforcement layer overlies a second heel area of the heel portion. The first reinforcement layer and the second reinforcement layer are separated at the heel portion.

Abstract: A shoe sole includes a first sole layer including a first region having a first rigidity, and a second region extending in a longitudinal direction of the shoe sole. The second region is spaced from a toe edge of the first sole layer and is spaced from a heel edge of the first sole layer. The first sole layer has a cleat engagement part. The second region is located between the cleat engagement part and a side edge of the first sole layer.

Abstract: A shoe sole includes a first sole layer including a first region having a first rigidity, and a plurality of second regions having a second rigidity that is more flexible than the first rigidity. The plurality of the second regions extends in a longitudinal direction of the shoe sole. The plurality of the second regions is spaced from a toe edge of the first sole layer, and is spaced from a heel edge of the first sole layer. The plurality of the second regions has arcuate shapes bending in a same lateral direction.

Abstract: A shoe basically includes an upper and a sole. The sole is attached to the upper. The sole includes an outsole and a first midsole. The first midsole has a fore part, a first heel part, a second heel part and a boundary part. The first heel part is at least partly disposed along a longitudinal centerline of the shoe and configured to support a center part of a heel. The second heel part is disposed laterally outward of the longitudinal centerline of the shoe and configured to support an outer part of the heel. The boundary part is provided between the first heel part and the second heel part such that the first heel part and the second heel part are movable relative to one another.

Abstract: A shoe basically includes an upper and a sole. The sole is attached to the upper. The sole includes an outsole and a first midsole. The first midsole has a fore part, a first heel part, a second heel part and a boundary part. The first heel part is at least partly disposed along a longitudinal centerline of the shoe and configured to support a center part of a heel. The second heel part is disposed laterally outward of the longitudinal centerline of the shoe and configured to support an outer part of the heel. The boundary part is provided between the first heel part and the second heel part such that the first heel part and the second heel part are movable relative to one another.

Abstract: A shoe includes a shoe sole and an upper coupled to the shoe sole. The upper has an upper body and an annular holding portion. The upper body has an opening portion for entry and removal of a wearer's foot. The annular holding portion is stretchable and configured to hold the wearer's foot. The annular holding portion is coupled to the opening portion. The opening portion has an edge that includes a first edge portion and a second edge portion. The first edge portion is located on a rear end in a longitudinal direction. The second edge portion is located forward of the first edge portion. The holding portion has a first degree of mobility relative to the first edge portion and a second degree of mobility relative to the second edge portion. The second degree of mobility is higher than the first degree of mobility.

Abstract: The present invention provides with a therapeutic agent for arthritis, which contains a low-molecular-weight FoxM1 inhibitor, e.g., thiostrepton, as an active ingredient. FoxM1 is expressed in an osteoclast progenitor that occurs specifically in an inflamed synovium in arthritis, and is not involved in the function of an osteoclast that is present in the bone marrow in a normal person and is involved in normal bone metabolism. Therefore, arthritis can be prevented and/or treated without any adverse side effect by using a FozM1 inhibitor.

Abstract: A bicycle shoe includes a sole. The sole includes a recess, which is recessed from a bottom surface of the sole. The recess is defined by a bottom portion and lateral surfaces. The bottom portion has a lateral dimension, which is greater than or equal to 20 millimeters and less than or equal to 45 millimeters.

Abstract: A bicycle cleat positioning device includes a shoe holder, a cleat holder, and an attachment portion. A bicycle shoe is mounted to the shoe holder. The cleat holder is adjustably arranged relative to the shoe holder. The attachment portion supports the cleat holder relative to the shoe holder. The cleat holder is detachably and rotatable mounted to the attachment portion.

Abstract: A shoe positioning plate has a shoe facing side surface, a sole surface and a shoe positioning member. The sole surface is configured to be a part of a shoe sole when the shoe facing side surface is attached the shoe sole. The shoe positioning member includes at least one abutment disposed on an opposite side of the shoe positioning plate from the shoe facing side surface and extending in an elongated direction of a shoe when the shoe positioning plate is attached the shoe sole.

Abstract: A bicycle shoe includes a sole. The sole includes a recess, which is recessed from a bottom surface of the sole. The recess is defined by a bottom portion and lateral surfaces. The bottom portion has a lateral dimension, which is greater than or equal to 20 millimeters and less than or equal to 45 millimeters.

Abstract: A bicycle cleat positioning kit includes a reference indicating instrument and a cleat adjusting instrument. The reference indicating instrument includes a shoe reference indicator with respect to a bicycle shoe. The cleat adjusting instrument includes a cleat adjusting indicator indicative of an adjustment amount of a cleat with respect to the shoe reference indicator of the reference indicating instrument.

Abstract: A bicycle cleat positioning kit includes a foot locating instrument and a foot measuring instrument. The foot locating instrument includes a foot support surface. The foot measuring instrument includes a foot reference indicator indicative of a foot reference location and a cleat attachment indicator indicative of a cleat attachment location relative to the foot reference indicator.

Abstract: A bicycle cleat positioning device includes a shoe holder, a cleat holder, and an attachment portion. A bicycle shoe is mounted to the shoe holder. The cleat holder is adjustably arranged relative to the shoe holder. The attachment portion supports the cleat holder relative to the shoe holder. The cleat holder is detachably and rotatable mounted to the attachment portion.

Abstract: A bicycle cleat positioning kit includes a reference indicating instrument and a cleat adjusting instrument. The reference indicating instrument includes a shoe reference indicator with respect to a bicycle shoe. The cleat adjusting instrument includes a cleat adjusting indicator indicative of an adjustment amount of a cleat with respect to the shoe reference indicator of the reference indicating instrument.

Abstract: A bicycle cleat positioning kit includes a foot locating instrument and a foot measuring instrument. The foot locating instrument includes a foot support surface. The foot measuring instrument includes a foot reference indicator indicative of a foot reference location and a cleat attachment indicator indicative of a cleat attachment location relative to the foot reference indicator.

Abstract: A shoe positioning plate has a shoe facing side surface, a sole surface and a shoe positioning member. The sole surface is configured to be a part of a shoe sole when the shoe facing side surface is attached the shoe sole. The shoe positioning member includes at least one abutment disposed on an opposite side of the shoe positioning plate from the shoe facing side surface and extending in an elongated direction of a shoe when the shoe positioning plate is attached the shoe sole.

Abstract: A bicycle shoe has an upper portion with a sole attached to the upper portion. The sole has upper and lower outer surfaces that define a toe section, an arch section, a ball section and a heel section with a longitudinal axis extending between the toe and heel sections. The ball section has a cleat attachment area surrounding at least one cleat attachment hole extending between the upper and lower outer surfaces. At least the arch section is configured with a transverse cross section having a center sole area with a first predetermined height, a medial side sole area with a second predetermined height and a lateral outside sole area with a third predetermined height, the first predetermined height being smaller than said second and third predetermined heights. Preferably, the sole upper and lower inner surfaces defining an interior cavity.

Abstract: A solid pharmaceutical preparation comprising a pharmaceutically active ingredient, erythritol, crystalline cellulose and an disintegrants, which exhibits a fast buccal disintegratability and dissolubility.

Abstract: A solid pharmaceutical preparation comprising a pharmaceutically active ingredient, erythritol, crystalline cellulose and an disintegrants, which exhibits a fast buccal disintegratability and dissolubility.