Patents by Inventor Jun O. Liu

Jun O. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
    Publication number: 20170071940
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivative thereof or a pharmaceutical salt thereof.
    Type: Application
    Filed: November 29, 2016
    Publication date: March 16, 2017
    Applicants: Texas Southern University, The Board of Regents of the University of Texas System
    Inventors: Omonike Arike Olaleye, Sarah Finney John, Janice Endsley, Jun O. Liu, Rosa Maldonado
  • IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS
    Publication number: 20160354498
    Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
    Type: Application
    Filed: March 17, 2016
    Publication date: December 8, 2016
    Inventors: Martin G. Pomper, Richard Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
  • ITRACONAZOLE ANALOGS AND USE THEREOF
    Publication number: 20160264556
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: May 23, 2016
    Publication date: September 15, 2016
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Itraconazole analogs and use thereof
    Patent number: 9346791
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 24, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • HYBRID CYCLIC LIBRARIES AND SCREENS THEREOF
    Publication number: 20160115203
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Application
    Filed: January 4, 2016
    Publication date: April 28, 2016
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Hybrid cyclic libraries and screens thereof
    Patent number: 9250237
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Grant
    Filed: November 29, 2011
    Date of Patent: February 2, 2016
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Chirally pure isomers of itraconazole for use as angiogenesis inhibitors
    Patent number: 9095589
    Abstract: Described herein are methods of inhibiting angiogenesis, and treating and preventing disorders associated with angiogenesis by administering anti-angiogenesis compounds to a subject.
    Type: Grant
    Filed: April 11, 2012
    Date of Patent: August 4, 2015
    Assignee: Johns Hopkins University
    Inventors: Jun O. Liu, Curtis R. Chong, Jing Xu, Jun Lu, Shridhar Bhat, Wie Shi
  • Methionine Aminopeptidase Inhibitors for Treating Infectious Diseases
    Publication number: 20150141415
    Abstract: The present invention relates to methods for treating an infectious disease in a subject in need thereof via administration of a therapeutically effective amount of compounds described herein. The methods may utilize particular compounds, for example, a quinoline, a hydrazone, a quinone, or a pyrimidine derivatives thereof or a pharmaceutical salts thereof.
    Type: Application
    Filed: November 7, 2014
    Publication date: May 21, 2015
    Inventors: Omonike Arike Olaleye, Sarah Finney John, Adaugo Chimzurum Isichei, Jun O Liu, Rosa Maldonado, Janice Endsley
  • Itraconazole Analogs and Use Thereof
    Publication number: 20140221393
    Abstract: Provided herein are Itraconazole analogs. Also provided herein are methods of inhibition of Hedgehog pathway, vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, angiogenesis and treatment of disease with Itraconazole analogs.
    Type: Application
    Filed: September 7, 2012
    Publication date: August 7, 2014
    Inventors: Jun O. Liu, Wei Shi, Kalyan Kumar Pasunooti
  • Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders
    Patent number: 8729097
    Abstract: Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.
    Type: Grant
    Filed: October 6, 2009
    Date of Patent: May 20, 2014
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Joong Sup Shim, Curtis R. Chong, Shridhar Bhat
  • Hybrid Cyclic Libraries and Screens Thereof
    Publication number: 20140073581
    Abstract: Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the deconvolution of hits using partially split-pooled library compounds. Such methods are applicable for use with the entire human proteome to screen such libraries that bind and for the identification of hits.
    Type: Application
    Filed: November 29, 2011
    Publication date: March 13, 2014
    Inventors: Jun O. Liu, Jingxin Wang, Zufeng Guo, Wei Li, Shridhar Bhat, Manisha Das
  • Phenazine derivatives and uses thereof as potassium channel modulators
    Patent number: 8669257
    Abstract: The present invention provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein each of W, Q, R1, R2, R3, R4, R5, m, and n is as defined herein, pharmaceutically acceptable compositions thereof, and methods of using the same.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: March 11, 2014
    Assignee: The Johns Hopkins University
    Inventors: Jun O. Liu, Yunzhao Ren, Fan Pan, Curtis R. Chong, Reinhold Penner, Jonathan R. Behr
  • Hedgehog pathway antagonists to treat disease
    Patent number: 8653083
    Abstract: Compounds, compositions, kits and methods for modulating hedgehog pathway activity, and treating conditions related to abnormal or aberrant hedgehog pathway activity, are disclosed.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: February 18, 2014
    Assignee: The Johns Hopkins University
    Inventors: Philip A. Beachy, Jun O. Liu
  • CHIRALLY PURE ISOMERS OF ITRACONAZOLE FOR USE AS ANGIOGENESIS INHIBITORS
    Publication number: 20130102614
    Abstract: Described herein are methods of inhibiting angiogenesis, and treating and preventing disorders associated with angiogenesis by administering anti-angiogenesis compounds to a subject.
    Type: Application
    Filed: April 11, 2012
    Publication date: April 25, 2013
    Inventors: Jun O. Liu, Curtis R. Chong, Jing Xu, Juu Lu, Shridhar Bhat
  • INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS
    Publication number: 20120196852
    Abstract: The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using various naphthoquinone, hydroxyquinonline, and naphthothiazole compounds.
    Type: Application
    Filed: August 5, 2010
    Publication date: August 2, 2012
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Omonike Arike Olaleye, Shridhar Bhat
  • QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS
    Publication number: 20110301163
    Abstract: Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1 and/or angiogenesis, wherein a compound of the invention is administered to a subject.
    Type: Application
    Filed: October 6, 2009
    Publication date: December 8, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Joong Sup Shim, Curtis R. Chong, Shridhar Bhat
  • CHIRALLY PURE ISOMERS OF ITRACONAZOLE AND INHIBITORS OF LANOSTEROL 14A-DEMETHYLASE FOR USE AS ANGIOGENESIS INHIBITORS
    Publication number: 20110262517
    Abstract: Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound is administered to a subject.
    Type: Application
    Filed: April 7, 2008
    Publication date: October 27, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Curtis R. Chong, Jing Xu, Jun Lu, Shridhar Bhat
  • IMAGING AND THERAPY OF VIRUS-ASSOCIATED TUMORS
    Publication number: 20110176998
    Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
    Type: Application
    Filed: October 13, 2010
    Publication date: July 21, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Richard Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
  • INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS
    Publication number: 20110124649
    Abstract: Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherein a compound of the invention is administered to a subject.
    Type: Application
    Filed: November 10, 2008
    Publication date: May 26, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Jun O. Liu, Xiaoyi Hu, Xiaochun Chen, Dawei Ma, Shridhar Bhat
  • MEHODS AND COMPOSITIONS FOR INHIBITING IMPDH-1 ISOFORM 1
    Publication number: 20100330148
    Abstract: Described herein are methods of inhibiting IMPDH type 1, and treating or preventing a disease or disorder (or symptoms thereof) associated with IMPDH type 1, wherein an IMPDH type 1 inhibitor compound is administered to a subject.
    Type: Application
    Filed: March 20, 2007
    Publication date: December 30, 2010
    Applicant: The Johns Hopkins University
    Inventors: Jun O. Liu, Curtis Robert Chong, David J. Sullivan