Abstract: The present invention pertains to a method for producing a protein oligomer comprising at least two, and preferably three heterodimeric human NC-I-Fc proteins, the method comprising: a) culturing a host cell expressing (i) a fusion protein comprising, from N- to C-terminus, human NC-1 from collagen 18 fused to human IgGI Fc with “knob” mutations, or human IgGI Fc with “knob” mutations fused to human NC-1 from collagen 18, and (ii) human IgGI Fc with “hole” mutations, under conditions which allow the formation of a protein oligomer comprising at least two, and preferably three heterodimeric human NC-1-Fc proteins, and wherein the fusion protein of (i) and the human IgGI Fc with “hole” mutations of (ii) are expressed in a ratio of 2:1 or higher, and b) obtaining the protein oligomer comprising at least two, and preferably three heterodimeric human NC-1-Fc proteins.

Abstract: The present invention is concerned with a protein oligomer comprising (i) at least two NC-1 monomers of collagen 18 or (ii) at least two endostatin domains of collagen 18 or (iii) at least two N-terminal peptides of the collagen 18 endostatin domain, for use in treating, ameliorating or preventing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.. The invention further relates to the mentioned protein oligomer for use for detecting and/or diagnosing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.

Abstract: The present invention is concerned with a protein oligomer comprising (i) at least two NC-monomers of collagen 18 or (ii) at least two endostatin domains of collagen 18 or (iii) at least two N-terminal peptides of the collagen 18 endostatin domain, for use in treating, ameliorating or preventing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease. The invention further relates to the mentioned protein oligomer for use for detecting and/or diagnosing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.

Abstract: The present invention pertains to a method for producing a protein oligomer comprising at least two, and preferably three heterodimeric human NC-I-Fc proteins, the method comprising: a) culturing a host cell expressing (i) a fusion protein comprising, from N- to C-terminus, human NC-1 from collagen 18 fused to human IgGI Fc with “knob” mutations, or human IgGI Fc with “knob” mutations fused to human NC-1 from collagen 18, and (ii) human IgGI Fc with “hole” mutations, under conditions which allow the formation of a protein oligomer comprising at least two, and preferably three heterodimeric human NC-1-Fc proteins, and wherein the fusion protein of (i) and the human IgGI Fc with “hole” mutations of (ii) are expressed in a ratio of 2:1 or higher, and b) obtaining the protein oligomer comprising at least two, and preferably three heterodimeric human NC-1-Fc proteins.

Abstract: The present invention is concerned with a protein oligomer comprising (i) at least two NC-monomers of collagen 18 or (ii) at least two endostatin domains of collagen 18 or (iii) at least two N-terminal peptides of the collagen 18 endostatin domain, for use in treating, ameliorating or preventing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease. The invention further relates to the mentioned protein oligomer for use for detecting and/or diagnosing fibrosis or a fibrosis-associated disease, a vascular endothelial growth factor (VEGF)-related disease or a matrix metalloproteinase (MMP)-related disease.

Abstract: The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of HIV. The conjugates comprise the following components: (a) a transport mediator for the cell membrane, (b) an address protein or peptide for the import into the cell nucleus, and (c) a peptide nucleic acid (PNA) which is to be transported and can be hybridized with an HIV gene and can inhibit the expression of the HIV gene.

Abstract: Described is a diagnostic conjugate comprising (a) a transmembrane module (TPU), (b) an address module (AS), preferably an antisense peptide nucleic acid (PNA), and (c) a signaling module (SM). The conjugate is useful for intracellular imaging, preferably via MRI, and, e.g., for differentiating between tumor- and non-tumor cells.

Abstract: The invention relates to a conjugate for treating prokaryotic infections from a transport mediator penetrating the prokaryotic cell membrane and a desired compound to be introduced into the prokaryote and directed thereagainst, which compound is preferably a peptide nucleic acid (PNA) directed against a gene of the prokaryote giving antibiotic resistance.

Abstract: Described is a diagnostic conjugate comprising (a) a transmembrane module (TPU), (b) an address module (AS), preferably an antisense peptide nucleic acid (PNA), and (c) a signalling module (SM). Said conjugate is useful for intracellular imaging, preferably via MRI, and, e.g., for differentiating between tumor- and non-tumor cells.

Abstract: The invention relates to peptide nucleic acid (PNA) conjugates which inhibit the expression of the bcr/abl fusion gene characteristic of CML and are suited to treat chronic myeloid leukemia (CML).

Abstract: The invention relates to a conjugate for treating prokaryotic infections from a transport mediator penetrating the prokaryotic cell membrane and a desired compound to be introduced into the prokaryote and directed thereagainst, which compound is preferably a peptide nucleic acid (PNA) directed against a gene of the prokaryote giving antibiotic resistance.

Abstract: The present invention relates to conjugates for mediating a cell-specific, compartment-specific or membrane-specific to methods of active substances. The invention also relates to methods of preparing these conjugates as well as their use. The conjugates comprise: a transport mediator for the cell membrane, a cell-specific, compartment-specific or membrane-specific address protein or peptide, and an active substance to be transported.

Abstract: The invention relates to peptide nucleic acid (PNA) conjugates which can be used for treating diseases correlated with HIV, wherein the peptide nucleic acid (PNA) inhibits the gene expression of HIV. The conjugates comprise the following components: (a) a transport mediator for the cell membrane, (b) an address protein or peptide for the import into the cell nucleus, and (c) a peptide nucleic acid (PNA) which is to be transported and can be hybridized with an HIV gene and can inhibit the expression of the HIV gene.

Abstract: This invention relates to a suspension apparatus for control devices which can be assembled from a connection flange or connection rotary joint, support beam sections, elbow joints, or intermediate joints which can be connected with a wall or the body of a machine, and a coupling unit which can be connected to the control device. The support beam section comprises an essentially U-shaped base profile section and a cover profile section closing the same. The base profile section is divided, by means of a separating bar parallel to its crossbar, into a support part constructed as a closed hollow profile and an open U-shaped mounting part opposed to the bar. The connection bars, which proceed in a longitudinal direction in the support part and in the mounting part, are integrally formed with screw mountings.

Abstract: This invention relates to a suspension apparatus for control devices which can be assembled from a connection flange or connection rotary joint, support beam sections, angle units, or intermediate joints, which can be connected with a wall or a machine body and a coupling unit which can be connected with the control device. The support beam sections have an essentially U-shaped base profile section and a closing cover profile secton. The base profile section, with a separating bar positioned parallel to its bar, is divided into a support part constructed as a closed hollow profile and an open U-shaped mounting part turned away from the bar. In the support part and in the mounting part, longitudinally directed and penetrating connecting bars are integrally formed with screw mountings. The angle comprising a corner connector and a covering cap creates, for such suspension apparatus, a rigid, highly-stressable corner connector between support beam sections placed perpendicular to one another.

Abstract: This invention relates to a suspension apparatus for control devices, control panels and the like, which can be assembled from a connection flange or connection rotary joint, support body sections, angle units, and intermediary joints which can be connected with a wall or a machine body, and a coupling unit which can be connected with the control device, the control panel or the like. There is a stable support body section providing easy installation of the connection lines and a simple connection with the adjacent parts of the suspension apparatus. The support body sections comprise an essentially U-shaped base profile section which with a separating bar proceeding in parallel to its bar is divided into a closed support part and an open, U-shaped mounting part turned away from the bar. Longitudinally directed connection bars with penetrating threaded reception mountings are integrally formed both on the support part as well as on the mounting part.

Abstract: A switch box for wall attachment with a box-like cabinet body having a rear wall and four side walls, the open side of which body can be closed by a cabinet cover or a cabinet door. Using thin starting materials for the cabinet body, an increase of stability, in addition to the possibility of further attachment locations, can be attained by attaching a mounting angle in each of four corner areas on the internal side of the rear wall. The legs of the mounting angle, provided with threaded mounts, are positioned in a plane parallel to the rear wall and spaced at a distance therefrom. At least one external longitudinal side of a leg is provided with a recess for fixing a support strip which is firmly screwed in the area of the open side of the cabinet body. At least one threaded mount of every mounting angle is accessible by a boring in the rear wall of the cabinet body.

Abstract: The invention relates to a switching box with a framework support formed from framework side units. The switching box is sealed by having a bottom wall, top wall, two side walls, and the open sides of which can be closed by means of a cabinet door and a rear wall, or by means of two cabinet doors. The framework side units form a hollow profile, which have identical series of holes on the two sides that stand perpendicular to one another and are oriented toward the internal space of the box. The framework side units have a protruding sealing bar on the side which toward the external side of the box. The costs of parts and labor necessary for assembly are reduced while retaining universal construction. At least one portion of the framework side units are formed by multiple bending in a single piece with the bottom wall, the top wall and/or the side walls plates.

Abstract: This invention concerns an improved socket for a control panel of the type having four angled corner pieces, at least two transverse recess members and at least two longitudinal recess members forming a frame. Dimensional stability and torsional rigidity of the socket are greatly increased due to the fact that vertical connecting flanges are bent at right angles along the free edges of the panel-mounting flanges at least in the area of the vertical mounting flanges for mounting of the transverse recess member, and such connecting flanges are connected to the recess-member mounting flanges when the transverse recess members are installed.

Abstract: This invention concerns a device for establishing an electrically conductive connection between flat areas of two components which are made of metal with a substantially non-conductive coating and are held together by a nut and bolt through aligned boreholes. An electrically conductive connection with damaged areas on surfaces not visible from one side is made possible by various features, including: the borehole of the component beside the nut is enlarged to serve as a holding aperture; a claw retainer is permanently non-rotatably secured on the free side of the nut and rests with punch-cut claws of side legs on the side of the component which faces the nut; and the side legs of the claw retainer have U-shaped extensions passing through the holding aperture adjacent to the nut having additional punch-cut claws engaging the other component, which is away from the nut, on the side thereof which faces the component adjacent to the nut.