Patents by Inventor Justin Bryans

Justin Bryans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070264262
    Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
    Type: Application
    Filed: March 10, 2005
    Publication date: November 15, 2007
    Inventors: Alan Brown, Justin Bryans, Paul Glossop, Charlotte Glossop, Simmon Mantell
  • Publication number: 20070225333
    Abstract: Compounds of formula (I): or a pharmaceutically acceptable derivative thereof, wherein R represents C1-6alkyl (optionally substituted by C1-6alkyloxy or Het) or C1-6alkyloxy; R1 and R2 independently represent hydrogen, halo or C1-6alkyl, ring A represents Het1; X represents O or NR3; R3 represents hydrogen or C1-6alkyl; ring B represents a phenyl group or Het2, either of which may be optionally substituted with one or more groups selected from halo, CN, C1-6alkyloxy, CF3, C1-6alkyl, NH2 and NO2; Het and Het1 independently represent a 5- or 6-membered saturated, partially unsaturated or aromatic heterocyclic group comprising either (a) 1 to 4 nitrogen atoms, (b) one oxygen or one sulphur atom or (c) 1 oxygen atom or 1 sulphur atoms and 1 or 2 nitrogen atoms are useful for treating anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (including motion sickness), intrauterine growth ret
    Type: Application
    Filed: April 18, 2005
    Publication date: September 27, 2007
    Inventors: Justin Bryans, Patrick Johnson, Thomas Ryckmans, Alan Stobie
  • Publication number: 20070203132
    Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: Het represents 2-pyridinyl or 2-pyrimidinyl; R1 represents H, C1-3 alkyl or a nitrogen-containing heterocyclic ring having 5 or 6 ring atoms; R2 represents H, benzyl or C1-3 alkyl; and R3 represents H, methyl, methoxy or chloro; are useful for treating anxiety, cardiovascular disease (including angina, atherosclerosis, hypertension, heart failure, edema, hypernatremia), dysmenorrhoea (primary and secondary), endometriosis, emesis (motion sickness), intrauterine growth retardation, inflammation (including rheumatoid arthritis), mittlesmerchz, preclampsia, premature ejaculation, premature (preterm) labor and Raynaud's disease.
    Type: Application
    Filed: January 11, 2005
    Publication date: August 30, 2007
    Inventors: Justin Bryans, Patrick Johnson, Thomas Ryckmans, Alan Stobie
  • Publication number: 20060194794
    Abstract: A compound of formula (I), or a pharmaceutically acceptable derivative, wherein A, B, V, W, X, Y, and Z are as defined herein; pharmaceutical compositions thereof; and uses thereof.
    Type: Application
    Filed: May 1, 2006
    Publication date: August 31, 2006
    Inventors: Justin Bryans, Patrick Johnson, Thomas Ryckmans, Alan Stobie
  • Publication number: 20060084825
    Abstract: The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin™) of Formulas (I), (II), (III), and (IV) wherein R is C1-C10 alkyl or C3 -C10 cycloalkyl and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: October 19, 2004
    Publication date: April 20, 2006
    Applicant: Warner-Lambert Company
    Inventors: Justin Bryans, David Blakemore, Sophie Williams
  • Publication number: 20050250800
    Abstract: Novel substituted amino acids of formula are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders. Processes for the preparation and intermediates useful in the preparation are also disclosed.
    Type: Application
    Filed: August 11, 2003
    Publication date: November 10, 2005
    Inventors: Justin Bryans, David Horwell, Jean-Marie Receveur
  • Publication number: 20050215816
    Abstract: A method is provided for making an enantiomerically pure compound of the formula: in which R and R? represent C1-C10 alkyl, C2-C10 alkenyl or C3-C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g.
    Type: Application
    Filed: March 7, 2005
    Publication date: September 29, 2005
    Inventors: David Blakemore, Justin Bryans
  • Publication number: 20050159487
    Abstract: The invention is a novel series of cyclic amino acids which are useful in the treatment of epilepsy, faintness attacks, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), and inflammation, especially arthritis. A pharmaceutical composition containing a compound of the invention as well as methods of preparing the compounds and novel intermediates useful in the preparation of the final compounds are included.
    Type: Application
    Filed: March 11, 2005
    Publication date: July 21, 2005
    Inventors: Justin Bryans, David Horwell, Andrew Thorpe, David Wustrow, Po-Wai Yuen
  • Publication number: 20050154024
    Abstract: Compounds of formula (I), or pharmaceutically acceptable derivatives thereof, wherein: X represents —[CH2]a—R or —[CH2]a—O—[CH2]b—R; a represents a number selected from 0 to 6; b represents a number selected from 0 to 6; R represents H, CF3 or Het; Het represents an optionally substituted 5- or 6-membered saturated, partially saturated or aromatic heterocyclic ring; Y represents one or more substituents independently selected from —[O]c—[CH2]d—R1, which may be the same or different at each occurrence; c at each occurrence independently represents a number selected from 0 or 1; d at each occurrence independently represents a number selected from 0 to 6; R1 at each occurrence independently represents H, halo, CF3, CN or Het1; Het1 at each occurrence independently represents a 5- or 6-membered unsaturated heterocyclic ring; V represents a direct link or —O—; Ring A represents an optionally substituted 5- to 7-membered saturated heterocyclic ring, or a phenylene group; Q represents a direct link or
    Type: Application
    Filed: December 10, 2004
    Publication date: July 14, 2005
    Inventors: Justin Bryans, Patrick Johnson, Lee Roberts, Thomas Ryckmans
  • Publication number: 20050085526
    Abstract: The invention relates to indole derivatives and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The indole derivatives according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
    Type: Application
    Filed: October 5, 2004
    Publication date: April 21, 2005
    Inventors: Alan Brown, Justin Bryans, Mark Bunnage, Paul Glossop, Charlotte Lane, Russell Lewthwaite, Simon Mantell
  • Publication number: 20050059735
    Abstract: Pro-drug compounds of the formula (I) or (II) and compositions containing them are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. In the above formulae n, P, Q, R1, R2 and R3 are as defined in the specification. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy or pain.
    Type: Application
    Filed: October 28, 2004
    Publication date: March 17, 2005
    Inventors: Justin Bryans, David Blakemore, Sophie Williams
  • Publication number: 20050004182
    Abstract: The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
    Type: Application
    Filed: June 3, 2004
    Publication date: January 6, 2005
    Inventors: Alan Brown, Justin Bryans, Charlotte Alice Lane, Simon Mantell