Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.

Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.

Abstract: A needleless or high-pressure injection system for injecting treatment or therapeutic fluid to tissue of the lower urinary tract, such as the prostate or bladder, is provided. The systems or devices can release the therapeutic fluid or “injectate” at high-pressure out of one or more orifices at the end of an elongate shaft inserted into the urethra. Various embodiments can include a pneumatic or fully-pneumatic system adapted to selectively release the high-pressure injectate, while also providing firing or triggering protection.

Abstract: A high-pressure fluid injection system, which includes a rechargeable injection chamber with a proximal end, a distal end, and an internal opening extending from the proximal end to the distal end, a plunger slideably engaged with the internal opening of the injection chamber, an injection tube extending from the distal end of the injection chamber and in fluidic communication with the internal opening of the injection chamber, and a check valve between the proximal and distal ends of the injection chamber. The internal opening includes a high-pressure zone adjacent to the check valve and having a first diameter, and a low-pressure zone proximal to the high-pressure zone and having a second diameter that is larger than the first diameter.

Abstract: Described are various embodiments of surgical procedures, systems, implants, devices, tools, and methods, useful for treating pelvic conditions in a male or female, the pelvic conditions including incontinence (various forms such as fecal incontinence, stress urinary incontinence, urge incontinence, mixed incontinence, etc.), vaginal prolapse (including various forms such as enterocele, cystocele, rectocele, apical or vault prolapse, uterine descent, etc.), and other conditions caused by muscle and ligament weakness, the devices and tools including devices and tools for anchoring an implant to supportive tissue and adjusting the implant.

Abstract: Described are various embodiments of surgical procedures, systems, implants, devices, tools, and methods, useful for treating pelvic conditions in a male or female, the pelvic conditions including incontinence (various forms such as fecal incontinence, stress urinary incontinence, urge incontinence, mixed incontinence, etc.), vaginal prolapse (including various forms such as enterocele, cystocele, rectocele, apical or vault prolapse, uterine descent, etc.), and other conditions caused by muscle and ligament weakness, the devices and tools including devices and tools for anchoring an implant to supportive tissue and adjusting the implant.

Abstract: Various embodiments of a mesh or implant systems are provided. The implants can include one or more anchors, arms and the like. The anchors can include hingeable or patterned finger extension to facilitate tissue penetration and retention. Various tensioning and adjustment mechanisms, devices and methods are further provided for the implant systems.

Abstract: An implant wrapped around the gastroesophageal junction to treat gastroesophageal reflux disease is provided. The implant is positioned around the junction by navigating the implant partly around the junction by a first needle and pulling the remainder of the distance with a second needle. A suture connector can be affixed to the implant with a suture, which can be used to pull the implant into place around the gastroesophageal junction.

Abstract: A needleless fluid injection system (100) including an injection console (102), an injection chamber in operative communication with the console, an injectate shaft (104) in operative communication with the console, which has an injection lumen extending from a proximal end to a distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen proximate the distal end of the shaft. The injection lumen can include a sealing cap (40) at its distal end.

Abstract: A needleless fluid injection device including a flexible shaft with a proximal end, a distal end, an injection lumen extending from the proximal end to the distal end of the shaft, and at least one injection orifice extending through a wall of the injection lumen at the distal end of the shaft. The injection lumen can include a depth-limiting system (462) at its distal end for controlling the depth of insertion of the injection lumen relative to a target tissue of a patient. The injection lumen can alternatively or additionally include at least one guidance feature. The injection lumen can alternatively or additionally include at least one flow-modifying protrusion extending from the inner tubular wall of the injection lumen and toward a longitudinal axis of the injection lumen.

Abstract: An elongate medical device such as a guidewire, that may comprise a first elongate member having a proximal end, a distal end and a lumen there between, a second elongate member having a proximal end and a distal end, the second elongate member at least partially disposed in the first elongate member, a first connection between first elongate member and the second elongate member at the proximal end of the first elongate member, a second connection between the first elongate member and the second elongate member at the distal end of the first elongate member, and a third connection between the first elongate member and the second elongate member, the third connection disposed at a point between the first connection and the second connection, wherein the third connection is substantially at a location selected by the Method for Enhancing the Ratio of Torsional Stiffness to Transverse Flexibility.

Abstract: An endoscope adapter ring for a needleless fluid delivery system for delivering therapeutic fluids to treatment sites within a patient. The needless fluid delivery system can include an automated injector source and a needleless access device. The access device can include a delivery scope and a treatment specific applicator. The adapter ring is operably attached to the endoscope to keep the injector lumen in a known orientation for the use of a side injector.

Abstract: Embodiments of the invention are directed to a laser ablation system. In one embodiment, the laser ablation system comprises a shaft, a balloon, a laser fiber and a viewing fiber. The shaft has a proximal end and a distal end. The balloon is attached to the distal end of the shaft, a portion of which is within the balloon. The laser fiber has a distal end comprising a light dispenser that is configured to deliver laser light through the balloon. The viewing fiber is configured to image an interior balloon. In accordance with another embodiment, the laser ablation system comprises a shaft, a balloon and a laser fiber. The shaft has a proximal end and a distal end. The balloon is attached to the distal end of the shaft, which is within the balloon. The balloon includes an inflated state, in which the balloon is shaped to conform to a cavity of a patient. The laser fiber has a distal end comprising light dispenser that is configured to deliver laser light through the balloon.

Abstract: Described are devices useful to inject fluid to tissue without the use of a needle, and related methods; the devices include one or a combination of features such as ejection orifices (40), distal end control features, or combinations of these; the systems can include a fluid delivery system having an injector source and an access device; the access device can comprise a minimally invasive, tubular delivery lumen (34) such as a catheter or endoscope; the tube-like device further includes one or more apposing jets that are selectively fired to force the injection orifice of the tube-like device against the target tissue; selective firing can include a continuous firing during the injection to improve the efficiency of the treatment.

Abstract: A needleless injection system is provided to deliver therapeutic fluids to an internal treatment site in a patient, where the system is pressurized and is capable of compensating for differences in injection media viscosity and mechanical system characteristics. In one aspect, a needleless therapeutic fluid injection system is provided that includes modular, interchangeable components. In particular, the system includes a console that generally includes the electronic and/or hydraulic control components for the system, an injection chamber, and a shaft or catheter tube.

Abstract: In one aspect of this invention, control systems (100) are provided for controlling the inflation of a tissue tensioner or balloon for a fluid delivery system, such as for a needleless fluid injection device. In another aspect of the invention, a system for reducing the response time for jet injection of fluid is provided (200). In yet another aspect of the invention, systems and devices are provided for controlling the volume of fluid that is ejected from a fluid injection system, which systems include at least one stop (410) that is selectively rotated to limit the movement of a shaft (402) in a linear direction, thereby controlling the amount of fluid that is ejected from the system.

Abstract: An injection system (200) including an injection chamber (202) and an injectate reservoir (204) that is removably attached to the injection chamber via an intermediate connector (206). The connector extends at a first end from the chamber and terminates at an opposite end with a fitting, such as a luer fitting, to which the injectate reservoir can be attached. The connector can be a relatively flexible component, such as a flexible tube, which is capable of absorbing the energy of an impact or other manipulation of the system to prevent or minimize the possibility of premature disconnection of the reservoir from the system.

Abstract: Described are needleless injection systems (100) and methods that involve features including one or more of a tissue tensioner (114) and a fitting (111) for attaching to a distal end of a shaft, exemplary embodiments including: an elastic sleeve (10) sized to fit under tension about the distal end of a flexible scope, such as an endoscope; a non-metal, polymeric tube-like device being optionally attached to the elastic sleeve for delivering a therapeutic fluid to a treatment site within a patient wherein the elastic sleeve may include an integral balloon (tissue tensioner) feature that can be used to position the injection orifice of the tube-like device proximate a treatment area.

Abstract: An endoscope adapter ring for a needleless fluid delivery system for delivering therapeutic fluids to treatment sites within a patient. The needless fluid delivery system can include an automated injector source and a needleless access device. The access device can include a delivery scope and a treatment specific applicator. The adapter ring is operably attached to the endoscope to keep the injector lumen in a known orientation for the use of a side injector.

Abstract: A high-pressure fluid injection system, which includes a rechargeable injection chamber with a proximal end, a distal end, and an internal opening extending from the proximal end to the distal end, a plunger slideably engaged with the internal opening of the injection chamber, an injection tube extending from the distal end of the injection chamber and in fluidic communication with the internal opening of the injection chamber, and a check valve between the proximal and distal ends of the injection chamber. The internal opening includes a high-pressure zone adjacent to the check valve and having a first diameter, and a low-pressure zone proximal to the high-pressure zone and having a second diameter that is larger than the first diameter.