Abstract: An illumination cannula system for vitreous surgery. The cannula system has a plurality of illuminated cannula ports, each including a multiplicity of optical fibers annularly arranged about a central conduit channel provided with a double seal onto which a sleeve connector or boot of an infusion line adapter or sealing plug can be attached. The adapter includes an extended tube for discharging fluid beyond the terminations of the fibers. The double seal provides a convenient, positive snap-action sealing connection. Identical configurations of the cannula ports enable post-placement selection and interchange of infusion and instrumentation ports.