Patents by Inventor Kalyanam Shivkumar

Kalyanam Shivkumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200324116
    Abstract: The present invention provides systems and methods for monitoring cardiac autonomic nervous system activity and modulating parasympathetic control of cardiac function.
    Type: Application
    Filed: April 21, 2017
    Publication date: October 15, 2020
    Inventors: Jeffrey L. Ardell, Kalyanam Shivkumar
  • Publication number: 20200206510
    Abstract: The present invention provides systems and methods for modulating the plasticity and/or memory of the autonomic nervous system.
    Type: Application
    Filed: June 25, 2018
    Publication date: July 2, 2020
    Inventors: Jeffrey Laurence Ardell, Marmar Vaseghi, Kalyanam Shivkumar
  • Patent number: 10500349
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: December 10, 2019
    Assignee: The Regents of the University of California
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Patent number: 10426515
    Abstract: The present invention relates to systems and methods for accessing the left heart of a subject. For example, the invention includes a percutaneous inter-ventricular transseptal technique for accessing the left ventricle. In certain embodiments, the invention includes guiding a transseptal sheath to the right ventricle and positioning the transseptal sheath within the inter-ventricular septum.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: October 1, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventor: Kalyanam Shivkumar
  • Publication number: 20190184172
    Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.
    Type: Application
    Filed: August 25, 2017
    Publication date: June 20, 2019
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, GALVANI BIOELECTRONICS LIMITED
    Inventors: Jeffrey Laurence ARDELL, Kalyanam SHIVKUMAR, Arun SRIDHAR
  • Publication number: 20180296145
    Abstract: The present invention provides a device and methods of use related to the use of electrodes to detect the presence and abundance of various biochemical compounds of interest with high spatial and temporal resolution.
    Type: Application
    Filed: March 2, 2018
    Publication date: October 18, 2018
    Inventors: Kalyanam Shivkumar, Jeffrey Laurence Ardell, Corey Smith
  • Publication number: 20180116541
    Abstract: The present invention includes systems and methods for measuring, monitoring and treating arrhythmia and cardiac function via the intrinsic cardiac nervous system. The systems and methods compare neural signatures of the intrinsic cardiac nervous system that are associated with both healthy and diseased myocardial tissue to identify and target afferent intrinsic cardiac neurons for which signaling has been affected by diseased cardiac tissue. Accordingly, methods of modulating afferent neural signals from the diseased myocardium to the intrinsic cardiac nervous system, intrathoracic extracardiac ganglia, and higher centers of the cardiac neuraxis are used as a novel therapeutic approach to mitigating ischemic heart disease.
    Type: Application
    Filed: April 21, 2016
    Publication date: May 3, 2018
    Inventors: Kalyanam Shivkumar, Jeffrey L. Ardell
  • Publication number: 20180001037
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Application
    Filed: September 19, 2017
    Publication date: January 4, 2018
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Patent number: 9782548
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: October 10, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Publication number: 20170196650
    Abstract: Devices and methods are disclosed for preventing injury to a target tissue in proximity to the heart. The methods may include the use a device to externally manipulate the heart to move a portion of the heart away from the target tissue. The methods may also include applying therapy to the heart with the device.
    Type: Application
    Filed: March 28, 2017
    Publication date: July 13, 2017
    Inventor: Kalyanam Shivkumar
  • Patent number: 9603674
    Abstract: Devices and methods are disclosed for preventing injury to a target tissue in proximity to the heart. The methods may include the use a device to externally manipulate the heart to move a portion of the heart away from the target tissue. The methods may also include applying therapy to the heart with the device.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: March 28, 2017
    Assignee: The Regents of the University of California
    Inventor: Kalyanam Shivkumar
  • Publication number: 20150320845
    Abstract: The present invention provides compositions, systems, and methods for modulation of cardiac tissue. In one embodiment, the invention provides for bioenzymatic ablation of cardiac tissue. In certain embodiments, the present invention provides for application of collagenase or other therapeutic agents to digest targeted cardiac tissue.
    Type: Application
    Filed: May 7, 2015
    Publication date: November 12, 2015
    Inventor: Kalyanam Shivkumar
  • Publication number: 20150182255
    Abstract: The present invention relates to systems and methods for accessing the left heart of a subject. For example, the invention includes a percutaneous inter-ventricular transseptal technique for accessing the left ventricle. In certain embodiments, the invention includes guiding a transseptal sheath to the right ventricle and positioning the transseptal sheath within the inter-ventricular septum.
    Type: Application
    Filed: December 23, 2014
    Publication date: July 2, 2015
    Inventor: Kalyanam Shivkumar
  • Publication number: 20130289526
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Application
    Filed: March 5, 2013
    Publication date: October 31, 2013
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Patent number: 8419685
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: April 16, 2013
    Assignee: The Regents of the University of California
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Patent number: 8401638
    Abstract: A method for determining a cardiac shock strength, for example the programmed first-therapeutic shock strength of an implantable cardioverter defibrillator (ICD), including the steps of sensing a change in a T-wave of an electrogram with respect to time such as the maximum of the first derivative of a T-wave of an electrogram; delivering a test shock by (i) delivering a test shock at a test-shock strength and at a test-shock time relating to the maximum of the first derivative of the T-wave with respect to time; and (ii) sensing for cardiac fibrillation. If fibrillation is not sensed, test-shock delivery is repeated at the same test-shock strength and at specific, different test-shock times relating to the maximum of the first derivative of the T-wave. If fibrillation is still not sensed, the shock strength is decreased and test shocks are repeated at the same specific test shock times relative to the maximum of the first derivative of the T-wave.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: March 19, 2013
    Assignee: Imperception, Inc.
    Inventors: Charles D. Swerdlow, Kalyanam Shivkumar
  • Patent number: 7871408
    Abstract: The present invention comprises methods and systems for treating a cardiac arrhythmia in a mammal by administering gated or pulsed radiofrequency current or other ablative energy to the mammal during one or more time periods of increased coronary blood flow. Preferred embodiments of the invention comprise, without limitation, the gated or pulsed administration of radiofrequency current in association with the formation of the dicrotic notch in the arterial blood pressure curve of the mammal. In accordance with the invention, the thermal effects of ablative energy application on the coronary artery are avoided or mitigated due to rapid coronary blood flow resulting in heat loss and minimization of damage to blood vessels.
    Type: Grant
    Filed: October 27, 2005
    Date of Patent: January 18, 2011
    Assignee: Henry Ford Health System
    Inventors: Subramaniam Krishnan, Kalyanam Shivkumar, Suresh Rathnam
  • Publication number: 20100010442
    Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.
    Type: Application
    Filed: November 3, 2006
    Publication date: January 14, 2010
    Applicant: The Regents of the University of California
    Inventors: Kalyanam Shivkumar, David A. Cesario
  • Publication number: 20090326511
    Abstract: Devices and methods are disclosed for preventing injury to a target tissue in proximity to the heart. The methods may include the use a device to externally manipulate the heart to move a portion of the heart away from the target tissue. The methods may also include applying therapy to the heart with the device.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 31, 2009
    Inventor: Kalyanam Shivkumar
  • Publication number: 20080051841
    Abstract: A method for determining a cardiac shock strength, for example the programmed first-therapeutic shock strength of an implantable cardioverter defibrillator (ICD), including the steps of sensing a change in a T-wave of an electrogram with respect to time such as the maximum of the first derivative of a T-wave of an electrogram; delivering a test shock by (i) delivering a test shock at a test-shock strength and at a test-shock time relating to the maximum of the first derivative of the T-wave with respect to time; and (ii) sensing for cardiac fibrillation. If fibrillation is not sensed, test-shock delivery is repeated at the same test-shock strength and at specific, different test-shock times relating to the maximum of the first derivative of the T-wave. If fibrillation is still not sensed, the shock strength is decreased and test shocks are repeated at the same specific test shock times relative to the maximum of the first derivative of the T-wave.
    Type: Application
    Filed: August 21, 2007
    Publication date: February 28, 2008
    Inventors: Charles Swerdlow, Kalyanam Shivkumar