Patents by Inventor Kam W. Leong

Kam W. Leong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230321140
    Abstract: The present subject matter provides a series of multifunctional anti-inflammatory agents comprising tannic acid, Zn2+, and different amounts of gentamicin (TA-Zn-Gen NPs) to effectively improve sepsis treatment through five modes of anti-sepsis activity: (1) bound cfDNA with high affinity and inhibited cfDNA-induced activation of TLRs and nuclear factor kappa B (NF-?B) signaling; (2) inhibited activated macrophage-induced macrophage recruitment; (3) scavenged ROS and reduced ROS-induced DNA damage and cell death; (4) inhibited NO production induced by bacterial LPS; and (5) provided potent antibacterial activity.
    Type: Application
    Filed: April 10, 2023
    Publication date: October 12, 2023
    Inventors: Kam W. LEONG, Liu FENG, Dan SHAO
  • Publication number: 20230301931
    Abstract: The nanoparticulate system for delivering treating agents may be used, for example, for treating inflammation, or for treating cancer, such as oral cancer, and associated inflammation The system used in this manner provides a solution to oral cancer and its associated metastasis by providing a targeted therapy to deliver chemotherapeutics. The nanoparticulate system is in the form of cholesterol-modified polyamidoamine-G3 nanoparticles (PAMAM-Chol NPs), which are used as a carrier for at least one drug. The at least one drug may include at least one cancer drug, at least one corticosteroid, at least one anabolic steroid, at least one hormone (natural or synthetic), and combinations thereof.
    Type: Application
    Filed: August 16, 2021
    Publication date: September 28, 2023
    Inventors: Kam W. LEONG, Divya BHANSALI, Tianyu LI
  • Publication number: 20230190665
    Abstract: The present invention belongs to the technical field of nanomedicine, and relates to a method for preparing a therapeutic protein-loaded nanoparticle, as well as a therapeutic protein-loaded nanoparticle, a suspension and a pharmaceutical composition comprising the nanoparticle, and a pharmaceutical preparation comprising the nanoparticle, the suspension or the pharmaceutical composition. The present invention further relates to a use of the nanoparticle in manufacture of a pharmaceutical composition, wherein the pharmaceutical composition is useful in prevention or treatment of a disease that can be prevented or treated by the therapeutic protein comprised in the nanoparticle.
    Type: Application
    Filed: January 19, 2017
    Publication date: June 22, 2023
    Inventors: Hai-Quan Mao, Jose Luis Santos, Zhiyu He, Huahua Huang, Lixin Liu, Kam W. Leong, Yongming Chen
  • Publication number: 20220378888
    Abstract: A method for synthesizing cell membrane-biomimetic nanotherapeutics can include coating core particles with cell membrane materials using flash nanocomplexation (FNC). FNC is a turbulent mixing and self-assembly method that can produce cell membrane-coated nanotherapeutics in a reproducible and scalable manner. The FNC-produced cell membrane-coated particles demonstrate lower aggregation, polydispersity, and zeta potential, than nanoparticles prepared by conventional coating methods, such as conventional bulk-sonication. As such, the present method achieves more complete, homogeneous and controllable coating than conventional bulk-sonication methods.
    Type: Application
    Filed: August 12, 2022
    Publication date: December 1, 2022
    Inventors: Kam W. LEONG, Hanze HU, Dan SHAO, Chao YANG
  • Publication number: 20220313839
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Application
    Filed: April 22, 2022
    Publication date: October 6, 2022
    Inventors: Kam W. Leong, Yeh-Hsing Lao, Tzu-Chieh Ho, Smruthi Suryaprakash
  • Patent number: 11311629
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: April 26, 2022
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Kam W. Leong, Yeh-Hsing Lao, Tzu-Chieh Ho, Smruthi Suryaprakash
  • Patent number: 11298526
    Abstract: A device for promoting healing of an injury in a living being is provided. Such device is based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.
    Type: Grant
    Filed: September 9, 2019
    Date of Patent: April 12, 2022
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: Lisa S. Carnell, Emilie J. Siochi, Kam W. Leong
  • Publication number: 20210128746
    Abstract: The present invention discloses a multifunctional DNA-templated micelle system that has a payload carrier of at least a DNA bridge and a functionalized polyethylene glycol (PEG) segment. The micelle can be used to deliver molecules, such as drugs and polynucleotides, to targeted cells for pharmaceutical uses. The PEG segment provides a functional group, such as amine, for ligand conjugation. The DNA-templated micelle of the present invention is highly controllable in size, loading efficiency and tissue targeting, and can carry multiple payloads for targeted combination strategies in cancer therapy, such as gene delivery, gene therapy, and immunotherapy.
    Type: Application
    Filed: February 27, 2018
    Publication date: May 6, 2021
    Inventors: Kam W. LEONG, Yeh-Hsing LAO, Tzu-Chieh HO, Smruthi SURYAPRAKASH
  • Patent number: 10808335
    Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: October 20, 2020
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Hemraj A. Juwarker, Kam W. Leong, Jennifer Gamboa Jackman
  • Publication number: 20200171167
    Abstract: The present invention discloses cationic nucleic acid scavengers to effectively inhibit the activation of multiple nucleic acid sensing pattern recognition receptors (PRRs) to treat an inflammatory or immune response which is induced by a nucleic acid through the activation of the PRRs. The cationic nucleic acid scavengers include water soluble cationic polymers, cationic nanoparticles, and cationic micro-particles, and bind the nucleic acid in a manner that is independent of the sequences, structure or chemistry of the nucleic acid.
    Type: Application
    Filed: May 24, 2018
    Publication date: June 4, 2020
    Inventors: Kam W. LEONG, Wei LEONG, Bo PENG
  • Publication number: 20190388677
    Abstract: A device for promoting healing of an injury in a living being is provided. Such device is based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.
    Type: Application
    Filed: September 9, 2019
    Publication date: December 26, 2019
    Inventors: Lisa S. Carnell, Emilie J. Siochi, Kam W. Leong
  • Patent number: 10406346
    Abstract: A method and device for promoting healing of an injury in a living being are provided. Such method and device are based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: September 10, 2019
    Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Kam W. Leong
  • Publication number: 20190136416
    Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
    Type: Application
    Filed: September 4, 2018
    Publication date: May 9, 2019
    Applicant: DUKE UNIVERSITY
    Inventors: Bruce A. Sullenger, Hemraj A. Juwarker, Kam W. Leong, Jennifer Gamboa Jackman
  • Patent number: 10196603
    Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: February 5, 2019
    Assignee: The United States of America as represented by the Administrator of NASA
    Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
  • Publication number: 20180263919
    Abstract: The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.
    Type: Application
    Filed: March 9, 2018
    Publication date: September 20, 2018
    Inventors: Ahmet Hoke, Sing Y. Chew, Ruifa Mi, Kam W. Leong
  • Patent number: 10066323
    Abstract: Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: September 4, 2018
    Assignee: Duke University
    Inventors: Bruce A. Sullenger, Hemraj A. Juwarker, Kam W. Leong, Jennifer Gamboa Jackman
  • Publication number: 20170355954
    Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.
    Type: Application
    Filed: August 3, 2017
    Publication date: December 14, 2017
    Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
  • Publication number: 20170304214
    Abstract: The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents are nerve growth factors. In certain embodiments, the electrospun fiber compositions comprising one or more biologically active agents are on the surface of a film, or a tube. The tubes comprising the electrospun fiber compositions of the invention can be used, for example, as nerve guide conduits.
    Type: Application
    Filed: April 26, 2017
    Publication date: October 26, 2017
    Inventors: Ahmet Hoke, Sing Y. Chew, Ruifa Mi, Kam W. Leong
  • Publication number: 20170304488
    Abstract: The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.
    Type: Application
    Filed: November 11, 2015
    Publication date: October 26, 2017
    Inventors: Howard Levinson, Kam W. Leong, Elizabeth R. Lorden, Kyle J. Miller
  • Patent number: 9758761
    Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: September 12, 2017
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara